The Prognostic Performance of Log Odds of Positive Lymph Nodes in Patients with Esophageal Squamous Cell Carcinoma: A Population Study of the US SEER Database and a Chinese Single-Institution Cohort

2021 ◽  
Author(s):  
Hongdian Zhang ◽  
Wanyi Xiao ◽  
Peng Ren ◽  
Kai Zhu ◽  
Ran Jia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Seer Database ◽  
Single Institution ◽  
Prognostic Performance ◽  
The Us ◽  
Log Odds ◽  
Positive Lymph Nodes

scholarly journals Comprehensive analysis of prognostic value of lymph node classifications in esophageal squamous cell carcinoma: a large real-world multicenter study

2021 ◽  
Vol 13 ◽  
pp. 175883592110548
Author(s):  
Junmiao Wen ◽  
Jiayan Chen ◽  
Donglai Chen ◽  
Salma K. Jabbour ◽  
Tao Xue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Accuracy ◽  
Seer Database ◽  
Risk Of Death ◽  
Positive Lymph Nodes

Background: We aim to assess the prognostic ability of three common lymph node–based staging algorithms, namely, the number of positive lymph nodes (pN), the lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in patients with esophageal squamous cell carcinoma (ESCC). Methods: A total of 3902 ESCC patients treated at 10 Chinese institutions between 2003 and 2013 were included, along with 2465 patients from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic ability of the aforementioned algorithms was evaluated using time-dependent receiver operating characteristic (tdROC) curves, R2, Harrell’s concordance index (C-index), and the likelihood ratio chi-square score. The primary outcomes included cancer-specific survival (CSS), overall survival (OS), and CSS with a competing risk of death by non-ESCC causes. Results: LODDS had better prognostic performance than pN or LNR in both continuous and stratified patterns. In the multicenter cohort, the multivariate analysis showed that the model based on LODDS classification was superior to the others in predictive accuracy and discriminatory capacity. Two nomograms integrating LODDS classification and other clinicopathological risk factors associated with OS as well as cancer-specific mortality were constructed and validated in the SEER database. Finally, a novel TNLODDS classification which incorporates the LODDS classification was built and categorized patients in to three new stages. Conclusion: Among the three lymph node–based staging algorithms, LODDS demonstrated the highest discriminative capacity and prognostic accuracy for ESCC patients. The nomograms and novel TNLODDS classification based on LODDS classification could serve as precise evaluation tools to assist clinicians in estimating the survival time of individual patients and improving clinical outcomes postoperatively in the future.

scholarly journals Prognosis of patients with esophageal squamous cell carcinoma after esophagectomy using the log odds of positive lymph nodes

Oncotarget ◽  
2015 ◽  
Vol 6 (34) ◽  
pp. 36911-36922 ◽  
Author(s):  
San-Gang Wu ◽  
Jia-Yuan Sun ◽  
Li-Chao Yang ◽  
Juan Zhou ◽  
Feng-Yan Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Log Odds ◽  
Positive Lymph Nodes

The importance of log odds of positive lymph nodes for locoregional recurrence in oral squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 72 ◽  
pp. 48-55 ◽  
Author(s):  
Ali-Farid Safi ◽  
Martin Kauke ◽  
Andrea Grandoch ◽  
Hans-Joachim Nickenig ◽  
Uta Drebber ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locoregional Recurrence ◽  
Log Odds ◽  
Positive Lymph Nodes

163 TRANSHITAL ESOPHAGECTOMY IN THE TREATMENT OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
C Kruel ◽  
F Vieira ◽  
R Schramm ◽  
M Chedid ◽  
A Rosa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Neoadjuvant Therapy ◽  
Squamous Cell ◽  
Transhiatal Esophagectomy ◽  
Postoperative Treatment ◽  
Surgical Time ◽  
Positive Lymph Nodes

Abstract   In the state of Rio Grande do Sul, Brazil, it is encountered a very high incidence of. esophageal squamous cell carcinoma in the world.(1). Advances in surgical procedure techniques and. postoperative treatment have arisen in esophagectomy, which remains as with significant morbidity. and mortality. Compared to other esophagectomies. conducted with thoracotomy, such as Ivor-Lewis and McKeown techniques, the Transhiatal. esophagectomy has a shorter surgical time, a lower rate of mediastinitis and then lower morbidity. Methods Ninety-six patients undergoing transhiatal esophagectomy in the Hospital de Clínicas de Porto Alegre, between 2005 and 2017 were evaluated. Thirteen patients underwent neoadjuvant treatment with chemoradiotherapy. Ninety-day survival and 5-year survival were evaluated. Results Overall 90-day survival was 91.7%. The overall 5-year survival was 41.2%. Patients undergoing neoadjuvant therapy had a 90-day survival of 100% and a 5-year survival of 74.1%. Patients undergoing frontline esophagectomy had a 90-day survival of 90.3% and 5-year survival rate of 36%. Non-neoadjuvant patients with negative lymph nodes had a 5-year survival of 50.2%. The average surgical time was 253 minutes. Thirty-seven patients (38.5%) had positive lymph nodes in the surgical specimen. Multivariate analysis showed that surgical time and presence of positive lymph nodes are associated with a worse outcome. Conclusion Patients submitted to transhiatal esophagectomy present considerable long-term survival, which can be amplified in the absence of lymph node involvement. Operated patients who have undergone neoadjuvant therapy prior to surgery demonstrate increased survival times compared with those without treatment. References 1) Corley DA, Buffler PA. Oesophageal and gastric cardia adenocarcinomas: analysis of regional variation using the Cancer Incidence in Five Continents database. Int J Epidemiol. 2001 Dec;30(6):1415–25.

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