The Current Understanding and Potential Therapeutic Options to Combat COVID-19

2021 ◽  
Author(s):  
Srividya Subash ◽  
Shivam Pandit ◽  
Nagendra H G
Keyword(s):  
Therapeutic Options ◽  
Current Understanding

scholarly journals The current understanding and potential therapeutic options to combat COVID-19

Life Sciences ◽  
2020 ◽  
Vol 254 ◽  
pp. 117765 ◽  
Author(s):  
Venkatesh Pooladanda ◽  
Sowjanya Thatikonda ◽  
Chandraiah Godugu
Keyword(s):  
Therapeutic Options ◽  
Current Understanding

scholarly journals Medication-Related Osteonecrosis of the Jaw: A Critical Narrative Review

2021 ◽  
Vol 10 (19) ◽  
pp. 4367
Author(s):  
Alejandro I. Lorenzo-Pouso ◽  
José Bagán ◽  
Leticia Bagán ◽  
Pilar Gándara-Vila ◽  
Cintia M. Chamorro-Petronacci ◽  
...  
Keyword(s):  
Relevant Literature ◽  
Osteonecrosis Of The Jaw ◽  
Narrative Review ◽  
Therapeutic Options ◽  
Current Understanding ◽  
Published Data ◽  
Paradoxical Reaction ◽  
Current Trends ◽  
Orofacial Region

Background: Nearly two decades have passed since a paradoxical reaction in the orofacial region to some bone modifying agents and other drugs was recognized, namely medication-related osteonecrosis of the jaw (MRONJ). Purpose: The aim of this manuscript was to critically review published data on MRONJ to provide an update on key terminology, concepts, and current trends in terms of prevention and diagnosis. In addition, our objective was to examine and evaluate the therapeutic options available for MRONJ. Methods: The authors perused the most relevant literature relating to MRONJ through a search in textbooks and published articles included in several databases for the years 2003–2021. Results and conclusions: A comprehensive update of the current understanding of these matters was elaborated, addressing these topics and identifying relevant gaps of knowledge. This review describes our updated view of the previous thematic blocks, highlights our current clinical directions, and emphasizes controversial aspects and barriers that may lead to extending the accumulating body of evidence related to this severe treatment sequela.

scholarly journals Mirtazapine for treatment of visual snow syndrome: A case series with insights into pathophysiology and therapy

2020 ◽  
Vol 4 (1) ◽  
pp. 2514183X2092569
Author(s):  
Ozan Eren ◽  
Christoph J Schankin
Keyword(s):  
Visual Field ◽  
Case Series ◽  
Therapeutic Options ◽  
Current Understanding ◽  
Visual Symptoms ◽  
Beneficial Effects ◽  
Treatment Trials ◽  
Negative Results ◽  
Entire Visual Field ◽  
Patient Series

Background: Patients with visual snow syndrome (VSS) describe tiny flickering dots in the entire visual field resembling the noise of a poorly adjusted channel of analogue television with additional symptoms. Little is known about the pathophysiology and therapeutic options for this debilitating condition. Objectives: We present a case series of three patients with VSS taking mirtazapine, one of the most often prescribed antidepressants, and discuss the utility of antidepressants by reviewing our current understanding of pathophysiology and therapy. Results: Mirtazapine has no effect on VSS, neither positive nor negative. This is in line with the reports from the literature suggested only some beneficial effects from lamotrigine. Conclusions: Since the pathophysiology of VSS is not fully understood, we still rely on the reports of individual cases or patient series. This includes not only the positive, but also the negative results to avoid unnecessary treatment trials. Looking into the literature, antidepressants do not seem to be a solution for the visual symptoms. So far, best data exists for the anticonvulsant lamotrigine.

Dark and Peculiar

2019 ◽  
Vol 40 (2) ◽  
pp. 92-103 ◽  
Author(s):  
Janko Međedović ◽  
Goran Knežević
Keyword(s):  
Undergraduate Students ◽  
Study Design ◽  
Personal Characteristics ◽  
Emotional Reaction ◽  
Current Understanding ◽  
Male Students ◽  
Psychosis Proneness ◽  
Negative Emotional Reaction ◽  
Mind Set ◽  
Psychopathic Tendencies

Abstract. Earlier research suggested that militant extremists could have certain aspects of psychopathic and psychotic characteristics. Relying on these studies, we investigated whether the Militant Extremist Mind-Set (MEM) could be explained by psychopathy, sadism, and Disintegration (psychosis proneness), as subclinical manifestations of amoral, antisocial, and psychotic-like traits. In Study 1 (306 undergraduate students), it was shown that sadistic and psychopathic tendencies were related to Proviolence (advocating violence as a means for achieving a goal); psychopathic and disintegrative tendencies were associated to the Vile World (belief in a world as a corrupted and vile place), while Disintegration was the best predictor of Divine Power (relying on supernatural forces as a rationale for extremist acts). In Study 2 (147 male convicts), these relations were largely replicated and broadened by including implicit emotional associations to violence in the study design. Thus, while Proviolence was found to be related to a weakened negative emotional reaction to violent pictures, Vile World was found to be associated with stronger negative emotions as a response to violence. Furthermore, Proviolence was the only MEM factor clearly differentiating the sample of convicts from male students who participated in Study 1. Results help extend current understanding about personal characteristics related to militant extremism.

Therapeutic options in patients with malignant biliary obstruction – a retrospective single center analyze

2016 ◽  
Vol 54 (05) ◽  
Author(s):  
R Schwarzer ◽  
S Hametner ◽  
A Ziachehabi ◽  
S Gerstl ◽  
R Függer ◽  
...  
Keyword(s):  
Biliary Obstruction ◽  
Malignant Biliary Obstruction ◽  
Therapeutic Options ◽  
Single Center
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