3D Bioprinting of Functional Skin Substitutes for Chronic Wound Treatment: From Current Achievements to Future Goals

2020 ◽  
Author(s):  
Paula Gabriela Maniţă ◽  
Itxaso García-Orue ◽  
Edorta Santos-Vizcaíno ◽  
Rosa María Hernández ◽  
Manoli Igartua
Keyword(s):  
Chronic Wound ◽  
Wound Treatment ◽  
3D Bioprinting ◽  
Skin Substitutes ◽  
Future Goals

scholarly journals A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1622 ◽  
Author(s):  
Agata Przekora
Keyword(s):  
Chronic Wounds ◽  
Chronic Wound ◽  
Healing Process ◽  
Topical Delivery ◽  
Artificial Skin ◽  
Skin Tissue ◽  
Wound Treatment ◽  
Skin Grafts ◽  
Skin Substitutes ◽  
Modern Approach

Chronic wounds occur as a consequence of a prolonged inflammatory phase during the healing process, which precludes skin regeneration. Typical treatment for chronic wounds includes application of autografts, allografts collected from cadaver, and topical delivery of antioxidant, anti-inflammatory, and antibacterial agents. Nevertheless, the mentioned therapies are not sufficient for extensive or deep wounds. Moreover, application of allogeneic skin grafts carries high risk of rejection and treatment failure. Advanced therapies for chronic wounds involve application of bioengineered artificial skin substitutes to overcome graft rejection as well as topical delivery of mesenchymal stem cells to reduce inflammation and accelerate the healing process. This review focuses on the concept of skin tissue engineering, which is a modern approach to chronic wound treatment. The aim of the article is to summarize common therapies for chronic wounds and recent achievements in the development of bioengineered artificial skin constructs, including analysis of biomaterials and cells widely used for skin graft production. This review also presents attempts to reconstruct nerves, pigmentation, and skin appendages (hair follicles, sweat glands) using artificial skin grafts as well as recent trends in the engineering of biomaterials, aiming to produce nanocomposite skin substitutes (nanofilled polymer composites) with controlled antibacterial activity. Finally, the article describes the composition, advantages, and limitations of both newly developed and commercially available bioengineered skin substitutes.

scholarly journals 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals

2021 ◽  
Vol 14 (4) ◽  
pp. 362
Author(s):  
Paula Gabriela Manita ◽  
Itxaso Garcia-Orue ◽  
Edorta Santos-Vizcaino ◽  
Rosa Maria Hernandez ◽  
Manoli Igartua
Keyword(s):  
Point Of View ◽  
3D Bioprinting ◽  
Skin Substitutes ◽  
Basic Principles ◽  
Production Methods ◽  
Innovative Strategies ◽  
Physical Support ◽  
Future Goals ◽  
Clinical Point ◽  
3D Printed

The aim of this review is to present 3D bioprinting of skin substitutes as an efficient approach of managing skin injuries. From a clinical point of view, classic treatments only provide physical protection from the environment, and existing engineered scaffolds, albeit acting as a physical support for cells, fail to overcome needs, such as neovascularisation. In the present work, the basic principles of bioprinting, together with the most popular approaches and choices of biomaterials for 3D-printed skin construct production, are explained, as well as the main advantages over other production methods. Moreover, the development of this technology is described in a chronological manner through examples of relevant experimental work in the last two decades: from the pioneers Lee et al. to the latest advances and different innovative strategies carried out lately to overcome the well-known challenges in tissue engineering of skin. In general, this technology has a huge potential to offer, although a multidisciplinary effort is required to optimise designs, biomaterials and production processes.

scholarly journals Wounds: an overlooked burden (Part 1) – effective wound management starts with proper wound assessment

2020 ◽  
pp. 196-198
Author(s):  
H Parkar ◽  
AD Cromarty
Keyword(s):  
Wound Healing ◽  
General Practice ◽  
Healthcare Professionals ◽  
Chronic Wound ◽  
Treatment Strategies ◽  
Daily Basis ◽  
Wound Management ◽  
Wound Treatment ◽  
Wound Assessment ◽  
Wound Type

Healthcare professionals in general practice are tasked with treatment and management of wounds on a daily basis. The prognoses of these wounds are directly affected by the ability of the clinician to assess these wounds according to several parameters, including the wound type and the features which determine whether a wound is acute or transforming to a chronic wound. This can be achieved by proper and continuous wound assessment, which should guide wound treatment strategies to ensure optimal wound healing and prevent progression to complicated wounds.

Skin substitutes for acute and chronic wound healing: an updated review

2020 ◽  
Vol 31 (6) ◽  
pp. 639-648 ◽  
Author(s):  
Christina Dai ◽  
Shawn Shih ◽  
Amor Khachemoune
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Skin Substitutes

Comparison of Skin Substitutes for Acute and Chronic Wound Management

2021 ◽  
Vol 35 (03) ◽  
pp. 171-180
Author(s):  
Caroline Bay ◽  
Zachary Chizmar ◽  
Edward M. Reece ◽  
Jessie Z. Yu ◽  
Julian Winocour ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Relevant Literature ◽  
Wound Management ◽  
Foot Ulcers ◽  
Skin Substitute ◽  
Diabetic Foot Ulcers ◽  
Structural Elements ◽  
Skin Substitutes ◽  
Treatment Alternative ◽  
Chronic Wound Management

AbstractChronic and acute wounds, such as diabetic foot ulcers and burns, respectively, can be difficult to treat, especially when autologous skin transplantations are unavailable. Skin substitutes can be used as a treatment alternative by providing the structural elements and growth factors necessary for reepithelialization and revascularization from a nonautologous source. As of 2020, there are 76 commercially available skin substitute products; this article provides a review of the relevant literature related to the major categories of skin substitutes available.

scholarly journals Effects of Lucilia sericata Maggot Therapy in Chronic Wound Treatment: A Randomized Clinical Trial

2020 ◽  
Vol Volume 7 ◽  
pp. 11-17
Author(s):  
Ehsan Nezakati ◽  
Mohammad Hossain Hasani ◽  
Pouneh Zolfaghari ◽  
Marjan Rashidan ◽  
Mohammad Bagher Sohrabi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Chronic Wound ◽  
Lucilia Sericata ◽  
Wound Treatment ◽  
Maggot Therapy

scholarly journals Antibacterial Polyurethane Foams with Incorporated Lignin-Capped Silver Nanoparticles for Chronic Wound Treatment

2020 ◽  
Vol 59 (10) ◽  
pp. 4504-4514 ◽  
Author(s):  
A. Gala Morena ◽  
Ivaylo Stefanov ◽  
Kristina Ivanova ◽  
Sílvia Pérez-Rafael ◽  
Miguel Sánchez-Soto ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Chronic Wound ◽  
Polyurethane Foams ◽  
Wound Treatment

Polylactide nanofibers delivering doxycycline for chronic wound treatment

2019 ◽  
Vol 104 ◽  
pp. 109745 ◽  
Author(s):  
Sisi Cui ◽  
Xue Sun ◽  
Ke Li ◽  
Dongxia Gou ◽  
Yifa Zhou ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Wound Treatment

Evaluation of Chronic Wound Treatment with the SNaP Wound Care System versus Modern Dressing Protocols

2010 ◽  
Vol 126 (4) ◽  
pp. 1253-1261 ◽  
Author(s):  
Bruce Lerman ◽  
Leslie Oldenbrook ◽  
Shaundra L. Eichstadt ◽  
Justin Ryu ◽  
Kenton D. Fong ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Wound Care ◽  
Wound Treatment ◽  
System Versus ◽  
Care System
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