Prox1-Dependent Stimulation of Lymphatic Function Ameliorates Mesenteric Lesions and Modifies the Composition of Microbiota in Experimental Crohn's Disease

2020 ◽  
Author(s):  
Weisong Shen ◽  
Xiaohui Huang ◽  
Ruiqing Liu ◽  
Chenyang Li ◽  
Yihan Xu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lymphatic Function ◽  
Stimulation Of

Evidence for continuous stimulation of interleukin-6 production in Crohn's disease

1992 ◽  
Vol 102 (2) ◽  
pp. 514-519 ◽  
Author(s):  
Volker Gross ◽  
Tilo Andus ◽  
Inka Caesar ◽  
Michael Roth ◽  
Jürgen Schölmerich
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Interleukin 6 ◽  
Continuous Stimulation ◽  
Stimulation Of

scholarly journals Understanding Host-Adherent-InvasiveEscherichia coliInteraction in Crohn’s Disease: Opening Up New Therapeutic Strategies

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Allison Agus ◽  
Sébastien Massier ◽  
Arlette Darfeuille-Michaud ◽  
Elisabeth Billard ◽  
Nicolas Barnich
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Inflammation ◽  
Mucosal Inflammation ◽  
Opportunistic Pathogens ◽  
Epithelial Barrier Function ◽  
New Treatment ◽  
Opening Up ◽  
Mammalian Intestine ◽  
Stimulation Of

A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasiveEscherichia coli(AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn’s disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed.

scholarly journals Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1078 ◽  
Author(s):  
Jesus Cosin-Roger ◽  
Francisco Canet ◽  
Dulce C. Macias-Ceja ◽  
Laura Gisbert-Ferrándiz ◽  
Dolores Ortiz-Masiá ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Fibrosis ◽  
Murine Colitis ◽  
Pharmacological Stimulation ◽  
Primary Fibroblasts ◽  
Potential Strategy ◽  
Autophagy Inhibition ◽  
Stimulation Of ◽  
Inflammatory Effect

We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis.

scholarly journals NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8 + T cell migration

2017 ◽  
Vol 103 (1) ◽  
pp. 56-70 ◽  
Author(s):  
Kasper Vadstrup ◽  
Elisabeth Douglas Galsgaard ◽  
Helle Jensen ◽  
Lewis L. Lanier ◽  
James C. Ryan ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Cell Migration ◽  
T Cell ◽  
Crohn's Disease ◽  
Cd8 T Cell ◽  
Nkg2d Ligand ◽  
T Cell Migration ◽  
Ligand Expression ◽  
Stimulation Of

615 Stimulation of Expression of Ileal Fibroblast Growth Factor 19 (FGF19) by Bile Acids Is Reduced in Patients With Crohn's Disease

2016 ◽  
Vol 150 (4) ◽  
pp. S126
Author(s):  
Jonathan D. Nolan ◽  
Richard N. Appleby ◽  
Justine H. Zhang ◽  
Sarah Kennie ◽  
Catherine Williamson ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Growth Factor ◽  
Crohn's Disease ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19 ◽  
Stimulation Of

On-table endoscopy to define strictures and resection margins: experience from 178 operations for Crohn's disease using intraoperative endoscopy

2001 ◽  
Vol 3 (Supplement 2) ◽  
pp. 58-62
Author(s):  
G. Olaison ◽  
P. Andersson ◽  
P. Myrelid ◽  
K. Smedh ◽  
J. Soderholm ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Resection Margins ◽  
Intraoperative Endoscopy
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