Bone Defect Reconstruction Via Endochondral Ossification: A Developmental Engineering Strategy

2020 ◽  
Author(s):  
Rao Fu ◽  
Chuanqi Liu ◽  
Jiaqi Li ◽  
Yuxin Yan ◽  
Yun Xie ◽  
...  
Keyword(s):  
Bone Defect ◽  
Endochondral Ossification ◽  
Defect Reconstruction ◽  
Engineering Strategy ◽  
Developmental Engineering ◽  
Bone Defect Reconstruction

scholarly journals Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

2021 ◽  
Vol 12 ◽  
pp. 204173142110042
Author(s):  
Rao Fu ◽  
Chuanqi Liu ◽  
Yuxin Yan ◽  
Qingfeng Li ◽  
Ru-Lin Huang
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Repair ◽  
Endochondral Ossification ◽  
Current Knowledge ◽  
Endochondral Bone ◽  
Defect Reconstruction ◽  
Hypoxic Conditions ◽  
Bone Defect Reconstruction

Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation by mimicking the embryological process of intramembranous ossification. However, the clinical translation of these clinical strategies for bone repair is hampered by limited vascularization and poor bone regeneration after implantation in vivo. An alternative strategy for overcoming these drawbacks is engineering cartilaginous constructs by recapitulating the embryonic processes of endochondral ossification (ECO); these constructs have shown a unique ability to survive under hypoxic conditions as well as induce neovascularization and ossification. Such developmentally engineered constructs can act as transient biomimetic templates to facilitate bone regeneration in critical-sized defects. This review introduces the concept and mechanism of developmental BTE, explores the routes of endochondral bone graft engineering, highlights the current state of the art in large bone defect reconstruction via ECO-based strategies, and offers perspectives on the challenges and future directions of translating current knowledge from the bench to the bedside.

scholarly journals Bone defect reconstruction with autologous bone inactivated with liquid nitrogen after resection of primary limb malignant tumors

Medicine ◽  
2020 ◽  
Vol 99 (24) ◽  
pp. e20442 ◽  
Author(s):  
Yuan Li ◽  
Yongkun Yang ◽  
Zhen Huang ◽  
Huachao Shan ◽  
Hairong Xu ◽  
...  
Keyword(s):  
Liquid Nitrogen ◽  
Bone Defect ◽  
Malignant Tumors ◽  
Defect Reconstruction ◽  
Autologous Bone ◽  
Bone Defect Reconstruction

Maxillary Bone Defect Reconstruction Using Porous Polyethylene Implants

2011 ◽  
Vol 22 (6) ◽  
pp. 2337-2340 ◽  
Author(s):  
Pâmela Letícia dos Santos ◽  
Joel Ferreira Santiago Jr ◽  
Daniela Ponzoni ◽  
Alessandra Marcondes Aranega ◽  
Thallita Pereira Queiroz ◽  
...  
Keyword(s):  
Bone Defect ◽  
Porous Polyethylene ◽  
Maxillary Bone ◽  
Defect Reconstruction ◽  
Bone Defect Reconstruction ◽  
Porous Polyethylene Implants

scholarly journals Effect of Bifunctional β Defensin 2-Modified Scaffold on Bone Defect Reconstruction

ACS Omega ◽  
2020 ◽  
Vol 5 (8) ◽  
pp. 4302-4312 ◽  
Author(s):  
Yiyu Peng ◽  
Lunhao Li ◽  
Qingyue Yuan ◽  
Ping Gu ◽  
Zhengwei You ◽  
...  
Keyword(s):  
Bone Defect ◽  
Defect Reconstruction ◽  
Bone Defect Reconstruction

scholarly journals Correction to: Bone defect reconstruction with a novel biomaterial containing calcium phosphate and aluminum oxide reinforcement

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alexander M. Keppler ◽  
Maximilian M. Saller ◽  
Paolo Alberton ◽  
Ines Westphal ◽  
Frank Heidenau ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Aluminum Oxide ◽  
Bone Defect ◽  
Defect Reconstruction ◽  
Bone Defect Reconstruction

An amendment to this paper has been published and can be accessed via the original article.

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