Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production

2020 ◽  
Author(s):  
Xiaoting Chen ◽  
Mian Wu ◽  
Nan Liang ◽  
Junxi Lu ◽  
Shen Qu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Regulated Expression

scholarly journals cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone.

1987 ◽  
Vol 262 (13) ◽  
pp. 6373-6382 ◽  
Author(s):  
F. Flug ◽  
R.P. Copp ◽  
J. Casanova ◽  
Z.D. Horowitz ◽  
L. Janocko ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormone ◽  
Growth Hormone Gene ◽  
Cis Acting ◽  
Regulated Expression ◽  
Rat Growth

scholarly journals Thyroid Hormone-Regulated Expression of RC3/Neurogranin in the Immortalized Hypothalamic Cell Line GT1-7

2002 ◽  
Vol 69 (3) ◽  
pp. 902-909 ◽  
Author(s):  
Beatriz Morte ◽  
Miguel Angel Iñiguez ◽  
Petra Isabel Lorenzo ◽  
Juan Bernal
Keyword(s):  
Thyroid Hormone ◽  
Cell Line ◽  
Regulated Expression

MULTIPLE DNA ELEMENTS DETERMINE BASAL AND THYROID HORMONE REGULATED EXPRESSION OF THE HUMAN GLYCOPROTEIN α SUBUNIT GENE IN PITUITARY CELLS

1990 ◽  
Vol 4 (2) ◽  
pp. 187-190 ◽  
Author(s):  
N.J. Balfour ◽  
J.A. Franklyn ◽  
J.A. Gurr ◽  
M.C. Sheppard
Keyword(s):  
Thyroid Hormone ◽  
Promoter Activity ◽  
Transcriptional Start Site ◽  
Pituitary Cells ◽  
Mrna Levels ◽  
Start Site ◽  
Subunit Gene ◽  
Α Subunit ◽  
Regulated Expression ◽  
Dna Elements

ABSTRACT Basal and thyroid hormone-regulated expression of constructs containing varying lengths of 5′ flanking sequence of the human glycoprotein hormone α subunit gene ligated to the reporter gene encoding chloramphenicol acetyl transferase (CAT) were examined in transfected pituitary GH3 cells. CAT gene expression was quantified by measurement of CAT enzyme activity. In addition, an RNase protection assay was used to confirm changes in CAT mRNA levels and to verify regulation of transcription from the authentic α gene start site. The pattern of basal α promoter activity indicated the presence of inhibitory DNA elements between −98 and −172 and upstream of −846 relative to the transcriptional start site, as well as a stimulatory element between −346 and −846. Each of the transfected constructs exhibited tri-iodothyronine inhibition of α promoter activity, suggesting the presence of an inhibitory thyroid hormone response element within 98 bp of the α gene transcriptional start site.

Sign in / Sign up

Export Citation Format

Share Document