High Plasma Concentration of Non-Esterified Polyunsaturated Fatty Acids Is a Specific Feature of Severe COVID-19 Pneumonia

2020 ◽  
Author(s):  
Maxime Nguyen ◽  
Abderrahmane Bourredjem ◽  
Lionel Piroth ◽  
Bélaïd Bouhemad ◽  
Antoine Jalil ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Plasma Concentration ◽  
Polyunsaturated Fatty Acids ◽  
High Plasma ◽  
High Plasma Concentration

Intoxication with Phenprocoumon (Marcoumar) Pharmacokinetics and Side Effects

1969 ◽  
Vol 21 (02) ◽  
pp. 320-324 ◽  
Author(s):  
K Seiler ◽  
F Duckert
Keyword(s):  
Plasma Concentration ◽  
Side Effects ◽  
Half Life ◽  
Plasma Proteins ◽  
Repeated Administration ◽  
High Plasma ◽  
Vitamin K1 ◽  
Clotting Factors ◽  
Therapeutic Concentration ◽  
High Plasma Concentration

SummaryA case of severe Marcoumar intoxication is described. Eleven hours after the intake a plasma concentration of 15.75 µg/ml was found which corresponds approximately to the 5-fold therapeutic concentration. Repeated administration of vitamin K1 made it possible to avoid extreme lowering of the activity of the clotting factors II, VII and X and to prevent bleeding. Side effects were not observed. The biologic half-life of Phenprocoumon has been found to be shortened at high plasma concentration (3.7 instead of 5.9 days). It is probable that in extreme concentration the drug is less strongly bound to the plasma proteins.

An unusually high plasma concentration of homocysteine resulting from a combination of so-called “secondary” etiologies

2020 ◽  
Vol 80 ◽  
pp. 52-55 ◽  
Author(s):  
Stéphane Jaisson ◽  
Aurore Desmons ◽  
Antoine Braconnier ◽  
Alain Wynckel ◽  
Philippe Rieu ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
High Plasma ◽  
High Plasma Concentration

scholarly journals Lipid metabolism and the risk factors of cardiovascular disease: implication of dietary omega-3 polyunsaturated fatty acids

2016 ◽  
Vol 41 (2) ◽  
pp. 223-223 ◽  
Author(s):  
Kayode A. Balogun
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Plasma Concentration ◽  
Polyunsaturated Fatty Acids ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Pufa Diet ◽  
Adipocyte Hypertrophy ◽  
Pufa Group

Cardiovascular disease (CVD) is a complicated and multifarious disease, and is the number one cause of mortality worldwide. The pathogenesis of CVD is attributed to the interaction between genetics and environment. There are numerous data that support the cardioprotective properties of omega (n)-3 polyunsaturated fatty acids (PUFA); however, there are also controversial reports. Considering the reported sex and age differences in the pathophysiology of CVD and the metabolism of n-3 PUFA, it is imperative to consider these factors in the cardioprotective effects of n-3 PUFA. The current thesis investigated the effects of n-3 PUFA on the risk factors of CVD, such as dyslipidemia and obesity, with a particular focus on how sex, age, and dose of n-3 PUFA affect lipid and lipoprotein metabolism. The plasma concentrations of lipids and lipoproteins of C57BL/6 mice offspring at weaning and 16 weeks postweaning were chosen as study outcomes to assess the sex, age, and dose-specific effects of n-3 PUFA on markers of dyslipidemia, a well-known risk factor of CVD. A longer exposure to a postnatal diet high in n-3 PUFA increased plasma concentration of low-density lipoprotein (LDL) cholesterol in the offspring in a sex-specific manner; however, the profile of this increase was less atherogenic, as the high n-3 PUFA group had a lower plasma concentration of very small LDL particles in both males and females. There was no effect of high n-3 PUFA diet observed on plasma concentration of high-density lipoprotein cholesterol; however, the high n-3 PUFA group had a higher cholesterol efflux in the male offspring but not in female offspring. Lipidomic analyses revealed that high n-3 PUFA diet led to higher hepatic and plasma concentrations of n-3 PUFA-containing bioactive lipids, such a phosphatidylcholine, lysophosphatidylcholine and free fatty acids, which could positively influence pathways involved in cardioprotection. The effects of dietary n-3 PUFA on obesity at the cellular level was also investigated, using adipocyte hypertrophy as the outcome measure of adipose tissue enlargement. A diet high in n-3 PUFA prevented adipocyte hypertrophy in males, with no effect in females. High n-3 PUFA diet also led to the downregulation of the messenger RNA expression of acyl-CoA:diacylglycerol acyltransferase 2, fatty acid binding protein-4, peroxisome proliferator-activated receptor protein γ, and leptin in males, which are key proteins involved in adipocyte hypertrophy; however, no effect was observed in females. The last study assessed the effects of dose and duration of exposure to dietary n-3 PUFA on docosahexaenoic acid accretion in the brain, and the expression of neurotrophins known to have neuroprotective and cardioprotective benefits. Dietary n-3 PUFA led to an age-dependent increase in the expression of brain-derived neurotrophic factor, tropomyosin receptor kinase, and phosphorylated cyclic AMP response element binding protein. In conclusion, the results from the current thesis demonstrate a sex-, dose-, and age-specific effect of n-3 PUFA on risk factors of CVD, and on novel regulatory pathways by which n-3 PUFA could reduce dyslipidemia and obesity. The results also suggest that n-3 PUFA could be neuroprotective and cardioprotective through a common neurotrophin signalling pathway.

High plasma concentration of myeloperoxidase in cirrhosis: A possible marker of hypersplenism

Hepatology ◽  
1993 ◽  
Vol 18 (6) ◽  
pp. 1377-1383 ◽  
Author(s):  
Makoto Nakamuta ◽  
Masao Ohashi ◽  
Yuichi Tanabe ◽  
Kaichiro Hiroshige ◽  
Hajime Nawata
Keyword(s):  
Plasma Concentration ◽  
High Plasma ◽  
High Plasma Concentration

Renal Functions in the Chimpanzee

1957 ◽  
Vol 190 (1) ◽  
pp. 117-120 ◽  
Author(s):  
John A. Gagnon ◽  
Robert W. Clarke
Keyword(s):  
Plasma Concentration ◽  
Glomerular Filtration ◽  
Renal Excretion ◽  
High Plasma ◽  
Tubular Secretion ◽  
Mutual Interference ◽  
Renal Functions ◽  
High Plasma Concentration ◽  
The Absolute

The excretion of creatinine and para-aminohippurate in five chimpanzees was found to be both by glomerular filtration and tubular secretion with mutual interference between the secretory processes. No evidence was found to suggest that inulin is subject to tubular secretion or reabsorption and it is therefore still acceptable for the measurement of glomerular filtration. The absolute values of glomerular filtration and renal excretion of creatinine and para-aminohippurate may have been modified by the use of anesthesia, but no striking differences are apparent between the kidney of the chimpanzee and that of man. PAH at high plasma concentration increases the excretion of potassium.

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