Premonitory Symptoms in Migraine from China: A Multiclinic Study of 4821 Patients

2020 ◽  
Author(s):  
Xiaolin Wang ◽  
Ziming Yin ◽  
Yajun Lian ◽  
Yanmei Xu ◽  
Ya Jie Li ◽  
...  
Keyword(s):  
Premonitory Symptoms

Current understanding of premonitory networks in migraine: A window to attack generation

Cephalalgia ◽  
2019 ◽  
Vol 39 (13) ◽  
pp. 1720-1727 ◽  
Author(s):  
Laura H Schulte ◽  
Kuan-Po Peng
Keyword(s):  
Sleep Disturbances ◽  
Integration Site ◽  
Basic Research ◽  
Rostral Ventromedial Medulla ◽  
Spinal Trigeminal Nucleus ◽  
Migraine Headaches ◽  
Migraine Pain ◽  
Ventromedial Medulla ◽  
External Stimuli ◽  
Premonitory Symptoms

Aim To describe neuronal networks underlying commonly reported migraine premonitory symptoms and to discuss how these might precipitate migraine pain. Background Migraine headache is frequently preceded by a distinct and well characterized premonitory phase including symptoms like yawning, sleep disturbances, alterations in appetite and food intake and hypersensitivity to certain external stimuli. Recent neuroimaging studies strongly suggest the hypothalamus as the key mediator of the premonitory phase and also suggested alterations in hypothalamic networks as a mechanism of migraine attack generation. When looking at the vast evidence from basic research within the last decades, hypothalamic and thalamic networks are most likely to integrate peripheral influences with central mechanisms, facilitating the precipitation of migraine headaches. These networks include sleep, feeding and stress modulating centers within the hypothalamus, thalamic pathways and brainstem centers closely involved in trigeminal pain processing such as the spinal trigeminal nucleus and the rostral ventromedial medulla, all of which are closely interconnected. Conclusion Taken together, these networks represent the pathophysiological basis for migraine premonitory symptoms as well as a possible integration site of peripheral so-called “triggers” with central attack facilitating processes.

scholarly journals Recognizing Syncope: Pitfalls and Surprises

1996 ◽  
Vol 89 (7) ◽  
pp. 372-375 ◽  
Author(s):  
T Lempert
Keyword(s):  
Creatine Kinase ◽  
Differential Diagnosis ◽  
Head Injury ◽  
Muscle Activity ◽  
Epileptic Seizures ◽  
Accurate Information ◽  
Loss Of Consciousness ◽  
Mere Presence ◽  
Key Features ◽  
Premonitory Symptoms

Loss of consciousness and falling are the key features of syncope. Common accompaniments include tonic and myoclonic muscle activity, eye deviations, automatisms, vocalizations and hallucinations which may render the distinction from epileptic seizures difficult. Differential diagnosis is based on the specific features and not the mere presence of these phenomena. Recognition of syncope depends also on accurate information about precipitants, premonitory symptoms and postictal events: the absence of postictal confusion has been identified as the single most powerful factor discriminating syncope from epileptic seizures whereas incontinence and head injury are common in both conditions. Investigations such as electroencephalogram, tilt testing and postictal prolactin or creatine kinase levels may be helpful but are never diagnostic in isolation. Exceptionally, hypoxic and epileptic mechanisms interact within a single attack.

scholarly journals CHOLERA WITHOUT PREMONITORY SYMPTOMS.

The Lancet ◽  
1854 ◽  
Vol 64 (1623) ◽  
pp. 301
Author(s):  
J.R. Oliver
Keyword(s):  
Premonitory Symptoms

Cerebral Circulation and Cerebral Blood Flow

2019 ◽  
pp. 79-85
Author(s):  
Arnoley S. Abcejo ◽  
Jeffrey J. Pasternak
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neurologic Outcomes ◽  
The Us ◽  
Hospital Cardiac Arrest ◽  
Premonitory Symptoms

Cardiac arrest occurs suddenly, often without premonitory symptoms. Consciousness is lost within seconds to minutes because of insufficient cerebral blood flow in the midst of complete hemodynamic collapse. Anoxic-ischemic brain injury is most commonly caused by cardiac arrest, which is frequently lethal; of the US patients with out-of-hospital cardiac arrest treated by emergency medical services, almost 90% die. Among the patients who survive to hospital admission, inpatient mortality may be decreasing, but a substantial number of those survivors have poor neurologic outcomes from anoxic-ischemic brain injury.

scholarly journals To Eat or Not to eat: A Review of the Relationship between Chocolate and Migraines

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 608 ◽  
Author(s):  
Magdalena Nowaczewska ◽  
Michał Wiciński ◽  
Wojciech Kaźmierczak ◽  
Henryk Kaźmierczak
Keyword(s):  
Current Literature ◽  
Trigger Factor ◽  
Google Scholar ◽  
Food Craving ◽  
Insufficient Evidence ◽  
Physiological Mechanisms ◽  
Clinical Databases ◽  
Chronic Disorder ◽  
The Relationship ◽  
Premonitory Symptoms

Migraine is a chronic disorder with episodic attacks, and patients with a migraine often report that certain factors can trigger their headache, with chocolate being the most popular type of food-based trigger. Many studies have suggested a link between chocolate and headaches; however, the underlying physiological mechanisms are unclear. As premonitory symptoms may herald migraine attacks, a question arises regarding whether eating chocolate before a headache is a consequence of a food craving or indeed a real trigger. Here, we aim to summarize the available evidence on the relationship between chocolate and migraines. All articles concerning this topic published up to January 2020 were retrieved by searching clinical databases, including EMBASE, MEDLINE, PubMed, and Google Scholar. All types of studies have been included. Here, we identify 25 studies investigating the prevalence of chocolate as a trigger factor in migraineurs. Three provocative studies have also evaluated if chocolate can trigger migraine attacks, comparing it to a placebo. Among them, in 23 studies, chocolate was found to be a migraine trigger in a small percentage of participants (ranging from 1.3 to 33), while all provocative studies have failed to find significant differences between migraine attacks induced by eating chocolate and a placebo. Overall, based on our review of the current literature, there is insufficient evidence that chocolate is a migraine trigger; thus, doctors should not make implicit recommendations to migraine patients to avoid it.

scholarly journals The Premonitory Symptoms of Insanity

BMJ ◽  
1886 ◽  
Vol 1 (1309) ◽  
pp. 188-190
Author(s):  
H. Sutherland
Keyword(s):  
Premonitory Symptoms

Dopamine and Migraine: Biology and Clinical Implications

Cephalalgia ◽  
2007 ◽  
Vol 27 (11) ◽  
pp. 1308-1314 ◽  
Author(s):  
S Akerman ◽  
PJ Goadsby
Keyword(s):  
Dopamine Receptors ◽  
Clinical Studies ◽  
Dopamine Agonists ◽  
Animal Studies ◽  
Neuronal Firing ◽  
Clinical Implications ◽  
Trigeminovascular System ◽  
Headache Pain ◽  
Dopaminergic Genes ◽  
Premonitory Symptoms

In the last 30 years dopamine has been considered as playing a role in the pathogenesis of migraine. The literature indicates that migraineurs are hypersensitive to dopamine agonists with respect to some of the premonitory symptoms of migraine such as nausea and yawning. There are various nonspecific dopamine D2 receptor antagonists that show good clinical efficacy in migraine, and also a number of polymorphisms of dopaminergic genes related to migraine. Animal studies have also shown that dopamine receptors are present in the trigeminovascular system, the area believed to be involved in headache pain, and neuronal firing here is reduced by dopamine agonists. There appears to be little effect of dopamine on peripheral trigeminal afferents. We assess some of the limitations of the clinical studies with regard to the therapeutics, and those found in the studies that discovered differences in genetic polymorphisms in migraine, and consider the implications of this on a dopaminergic hypothesis of migraine.

Sign in / Sign up

Export Citation Format

Share Document