Changes in Epidemiological Features of Vaccine Preventable Infectious Diseases Among Three Eras of National Vaccination Strategies from 1953 to 2018 in Shanghai, China

2020 ◽  
Author(s):  
Qiangsong Wu ◽  
Maryam Zaid ◽  
Zeliang Xuan ◽  
Chenxi Wang ◽  
Haiyan Gu ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Vaccination Strategies ◽  
Epidemiological Features

scholarly journals Spreading predictability in complex networks

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Na Zhao ◽  
Jian Wang ◽  
Yong Yu ◽  
Jun-Yan Zhao ◽  
Duan-Bing Chen
Keyword(s):  
Infectious Diseases ◽  
Prediction Model ◽  
Complex Networks ◽  
State Of The Art ◽  
Experimental Results ◽  
Vaccination Strategies ◽  
Macro Scale ◽  
Good Consistency ◽  
The Future ◽  
Rumor Control

AbstractMany state-of-the-art researches focus on predicting infection scale or threshold in infectious diseases or rumor and give the vaccination strategies correspondingly. In these works, most of them assume that the infection probability and initially infected individuals are known at the very beginning. Generally, infectious diseases or rumor has been spreading for some time when it is noticed. How to predict which individuals will be infected in the future only by knowing the current snapshot becomes a key issue in infectious diseases or rumor control. In this report, a prediction model based on snapshot is presented to predict the potentially infected individuals in the future, not just the macro scale of infection. Experimental results on synthetic and real networks demonstrate that the infected individuals predicted by the model have good consistency with the actual infected ones based on simulations.

scholarly journals CASES OF LEPTOSPIROSIS FOLLOWING INTERNATIONAL TRAVEL

2018 ◽  
Vol 23 (5) ◽  
pp. 251-255
Author(s):  
Ruslan Faritovich Sayfullin ◽  
N. N. Zvereva ◽  
L. S. Karan ◽  
E. M. Petrov ◽  
M. V. Bazarova ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
International Travel ◽  
Epidemiological Features ◽  
Relative Ratio

We present an analysis of 28 leptospirosis cases, associated with abroad traveling, and registered from 2011 to 2017 years. The relative ratio of leptospirosis with other imported infectious diseases is shown, and clinical and epidemiological features of imported leptospirosis cases were described

scholarly journals Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina

2012 ◽  
Vol 141 (4) ◽  
pp. 718-734 ◽  
Author(s):  
G. FABRICIUS ◽  
P. E. BERGERO ◽  
M. E. ORMAZABAL ◽  
A. L. MALTZ ◽  
D. F. HOZBOR
Keyword(s):  
Booster Dose ◽  
Deterministic Model ◽  
Risk Group ◽  
Age Group ◽  
Vulnerable Group ◽  
Vaccination Strategies ◽  
Epidemiological Features ◽  
Age Structured ◽  
The Impact ◽  
Positive Effect

SUMMARYDue to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.

Nucleic acid vaccination strategies against infectious diseases

2015 ◽  
Vol 12 (12) ◽  
pp. 1851-1865 ◽  
Author(s):  
Małgorzata Anna Marć ◽  
Enrique Domínguez-Álvarez ◽  
Carlos Gamazo
Keyword(s):  
Nucleic Acid ◽  
Infectious Diseases ◽  
Vaccination Strategies

scholarly journals Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses

2004 ◽  
Vol 72 (5) ◽  
pp. 2810-2816 ◽  
Author(s):  
Camilo Cuadros ◽  
Francisco J. Lopez-Hernandez ◽  
Ana Lucia Dominguez ◽  
Michael McClelland ◽  
Joseph Lustgarten
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Infectious Diseases ◽  
Immune Responses ◽  
Fusion Protein ◽  
Fusion Proteins ◽  
Inflammatory Responses ◽  
T Cell Response ◽  
Vaccination Strategies ◽  
Egfp Fusion Protein

ABSTRACT Vaccination is the most efficient prophylaxis against a variety of infectious diseases. New vaccination strategies rely on the incorporation of effective adjuvants, which stimulate the innate immune response and, in turn, activate the adaptive immune response. It is well established that flagellin induces inflammatory responses through the activation of antigen-presenting cells (APCs). In order to evaluate whether flagellin can serve as a carrier for the development of adjuvants or vaccines, we prepared a flagellin-enhanced green fluorescent protein (EGFP) fusion protein. Our results demonstrate that a flagellin-EGFP fusion protein is capable of stimulating APCs, resulting in the maturation of these cells and secretion of proinflammatory cytokines. Furthermore, APCs pulsed with the flagellin-EGFP fusion protein effectively process and present EGFP antigens. More importantly, animals immunized with the flagellin-EGFP fusion protein developed specific anti-EGFP T-cell responses. In contrast, recombinant EGFP was not able to stimulate APCs, nor did it induce a T-cell response. Thus, recombinant-flagellin fusion proteins may be suitable carriers as adjuvants or vaccines for the development of new vaccination strategies to induce and boost immune responses against infectious diseases and cancer.

scholarly journals How do pathogen evolution and host heterogeneity interact in disease emergence?

2006 ◽  
Vol 273 (1605) ◽  
pp. 3075-3083 ◽  
Author(s):  
Andrew Yates ◽  
Rustom Antia ◽  
Roland R Regoes
Keyword(s):  
Infectious Diseases ◽  
Real World ◽  
Host Population ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Disease Emergence ◽  
Adaptive Changes ◽  
Vaccination Strategies ◽  
Evolutionary Changes ◽  
Host Heterogeneity

Heterogeneity in the parameters governing the spread of infectious diseases is a common feature of real-world epidemics. It has been suggested that for pathogens with basic reproductive number R 0 >1, increasing heterogeneity makes extinction of disease more likely during the early rounds of transmission. The basic reproductive number R 0 of the introduced pathogen may, however, be less than 1 after the introduction, and evolutionary changes are then required for R 0 to increase to above 1 and the pathogen to emerge. In this paper, we consider how host heterogeneity influences the emergence of both non-evolving pathogens and those that must undergo adaptive changes to spread in the host population. In contrast to previous results, we find that heterogeneity does not always make extinction more likely and that if adaptation is required for emergence, the effect of host heterogeneity is relatively small. We discuss the application of these ideas to vaccination strategies.

DNA vaccination strategies against infectious diseases

1999 ◽  
Vol 29 (8) ◽  
pp. 1149-1163 ◽  
Author(s):  
Allison M. Watts ◽  
Ronald C. Kennedy
Keyword(s):  
Infectious Diseases ◽  
Dna Vaccination ◽  
Vaccination Strategies
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