A Prospective Observational Study of Clinico-Epidemiological Profiles and Associated Risk Factors of SARS-CoV-2 Positive Patients from India

2020 ◽  
Author(s):  
Dr Sumit Malhotra ◽  
Dr Manju Rahi ◽  
Dr Payal Das ◽  
Ms Rini Chaturvedi ◽  
Dr Jyoti Chhibber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Associated Risk Factors

scholarly journals Evaluation of clinico-epidemiological profile and associated risk factors of inguinal hernia. A Prospective observational study

2020 ◽  
Vol 4 (3) ◽  
pp. 31-36
Author(s):  
Dr. ASM Anwarul Kabir ◽  
Dr. Mohammad Ashik Anwar Bahar ◽  
Dr. Muhammad Faridul Haque ◽  
Dr. MA Osman Farooqui ◽  
Dr. Md. Babul Akter ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inguinal Hernia ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Epidemiological Profile ◽  
Associated Risk Factors

scholarly journals POS0441 DEVELOPMENT OF RHEUMATOID ARTHRITIS AMONG ANTI-CITRULLINATED PROTEIN ANTIBODIES POSITIVE ASYMPTOMATIC INDIVIDUALS: A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 449.1-449
Author(s):  
S. Mizuki ◽  
K. Horie ◽  
K. Imabayashi ◽  
K. Mishima ◽  
K. Oryoji
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Observational Study ◽  
Rheumatoid Factor ◽  
Prospective Observational Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Healthy Population ◽  
Asymptomatic Individuals ◽  
Citrullinated Protein

Background:In the idividuals with genetic and enviromental risk factors, immune events at mucosal surfaces occur and may precede systemic autoimmunity. Anti-citrullinated protein antibodies (ACPA) are present in the serum for an average of 3-5 years prior to the onset of rheumatoid arthritis (RA) during an asymptomatic period. In ACPA-positivite individuals, the additional presence of RA-related risk factors appears to add significant power for the development of RA. To date, there have been few reports in which clinical courses of ACPA-positive asymptomatic individuals were investigated prospectively.Objectives:To observe the clinical time course of ACPA-positive healthy population for the development of RA.Methods:Healthy volunteers without joint pain or stiffness, who attended the comprehensive health screening of our hospital, were enrolled in this prospective observational study. The serum ACPA levels were quantified by Ig-G anti-cyclic citrullinated peptide enzyme-linked immunosorbent assay with levels > 4.4 U/mL considered positive. ACPA-positive subjects were followed by rheumatologists of our department clinically or a questionnaire sent by mail for screening to detect arthritis.Results:5,971 healthy individuals without joint symptons were included. Ninty-two (1.5%) were positive for ACPA. Of these, 19 (20.7%) developed RA and two were suspected as RA by mail questionnaire. Their average age were 58-years, and women were 68%. The average duration between the date of serum sampling and diagnosis was 10.7 months. ACPA-positive individuals who developed to RA had higher serum ACPA and Ig-M rheumatoid factor levels than ACPA-positive individuals who did not (P value by Mann-Whitney U test: 0.002, 0.005, respectively).Conclusion:Among ACPA-positive asymptomatic individuals, 20% developed RA. The higher titer of ACPA and Ig-M rheumatoid factor levels are risk factors for devoloping RA.Disclosure of Interests:None declared

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