The Roborovski Dwarf Hamster – A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection

2020 ◽  
Author(s):  
Jakob Trimpert ◽  
Daria Vladimirova ◽  
Kristina Dietert ◽  
Azza Abdelgawad ◽  
Dusan Kunec ◽  
...  
Keyword(s):  
Dwarf Hamster ◽  
Fatal Course

scholarly journals The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection

Cell Reports ◽  
2020 ◽  
Vol 33 (10) ◽  
pp. 108488 ◽  
Author(s):  
Jakob Trimpert ◽  
Daria Vladimirova ◽  
Kristina Dietert ◽  
Azza Abdelgawad ◽  
Dusan Kunec ◽  
...  
Keyword(s):  
Dwarf Hamster ◽  
Fatal Course

Fatal course of maple syrup urine disease (MSUD) encephalopathy in a 6 year old boy with characteristic MRI-changes

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
V Boda ◽  
S Vlaho ◽  
S Dittrich ◽  
M Baz Bartels ◽  
S Parbel ◽  
...  
Keyword(s):  
Maple Syrup Urine Disease ◽  
Maple Syrup ◽  
Fatal Course ◽  
Urine Disease ◽  
Mri Changes

Fatal course of cerebral vasculitis induced by neuroborreliosis

2010 ◽  
Vol 58 (1) ◽  
pp. 139 ◽  
Author(s):  
Fredrik Buchwald ◽  
Kasim Abul-Kasim ◽  
Johan Tham ◽  
BjarneU Hansen
Keyword(s):  
Cerebral Vasculitis ◽  
Fatal Course

scholarly journals Effect of Exercise on Photoperiod-Regulated Hypothalamic Gene Expression and Peripheral Hormones in the Seasonal Dwarf Hamster Phodopus sungorus

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90253 ◽  
Author(s):  
Ines Petri ◽  
Rebecca Dumbell ◽  
Frank Scherbarth ◽  
Stephan Steinlechner ◽  
Perry Barrett
Keyword(s):  
Gene Expression ◽  
Phodopus Sungorus ◽  
Dwarf Hamster

Factor X Inhibitor: A Fulminant Presentation and Fatal Course of a Rare Syndrome in a 59-Year-Old Male

2013 ◽  
Vol 129 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Russell Gollard ◽  
Syed Rahman ◽  
Ramalingam Ratnasabapathy
Keyword(s):  
Factor X ◽  
Rare Syndrome ◽  
Fatal Course

scholarly journals Fatal Neonatal DOLK-CDG as a Rare Form of Syndromic Ichthyosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Katalin Komlosi ◽  
Olivier Claris ◽  
Sophie Collardeau-Frachon ◽  
Julia Kopp ◽  
Ingrid Hausser ◽  
...  
Keyword(s):  
Phenotypic Variability ◽  
Heart Tissue ◽  
Organ Involvement ◽  
Compound Heterozygous ◽  
Diagnostic Challenge ◽  
Second Child ◽  
Dilatative Cardiomyopathy ◽  
Collodion Baby ◽  
Fatal Course ◽  
Compound Heterozygous Variants

Neonatal collodion baby or ichthyosis can pose a diagnostic challenge, and in many cases, only additional organ involvement or the course of the disease will help differentiate between non-syndromic and syndromic forms. Skin abnormalities are described in about 20% of the congenital disorders of glycosylation (CDG). Among those, some rare CDG forms constitute a special group among the syndromic ichthyoses and can initially misdirect the diagnosis towards non-syndromic genodermatosis. DOLK-CDG is such a rare subtype, resulting from a defect in dolichol kinase, in which the congenital skin phenotype (often ichthyosis) is later associated with variable extracutaneous features such as dilatative cardiomyopathy, epilepsy, microcephaly, visual impairment, and hypoglycemia and may lead to a fatal course. We report two neonatal cases of lethal ichthyosis from the same family, with distal digital constrictions and a progressive course leading to multi-organ failure and death. Postmortem trio whole-exome sequencing revealed the compound heterozygous variants NM_014908.3: c.1342G>A, p.(Gly448Arg) and NM_014908.3: c.1558A>G, p.(Thr520Ala) in the DOLK gene in the first affected child, which were confirmed in the affected sibling. Reduced staining with anti-α-Dystroglycan antibody was observed in frozen heart tissue of the second child as an expression of reduced O-mannosylation due to the dolichol kinase deficiency. In addition to the detailed dermatopathological changes, both cases presented hepatic and extrahepatic hemosiderosis on histological examination. Our patients represent an early and fatal form of DOLK-CDG with a striking presentation at birth resembling severe collodion baby. Both cases emphasize the phenotypic variability of glycosylation disorders and the importance to broaden the differential diagnosis of ichthyosis and to actively search for organ involvement in neonates with ichthyosis.

scholarly journals EMPYEMA THORACIS

2010 ◽  
Vol 17 (03) ◽  
pp. 464-471
Author(s):  
MUHAMMAD SALEEM ◽  
MUHAMMAD ASIF QURESHI ◽  
MUHAMMAD ASIF I QURESH
Keyword(s):  
Operative Management ◽  
Community Acquired Pneumonia ◽  
Patient Treatment ◽  
Causative Organism ◽  
Empyema Thoracis ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Fatal Course ◽  
And Gender ◽  
One Year

Empyema as a complication of community acquired pneumonia (CAP) is relatively common occurrence in developing countries. Study Design: Prospective study. Period: 4 year Jan 2001- Dec 2004. Setting: Department of Pediatric surgery the Children’s hospital Lahore. Patients & Method: A total of 114 cases of empyema thoracic secondary to CAP were dealt with during this period, while in the same duration a total of 1768 cases of pneumonia were treated at the Children’s hospital Lahore. Results: Majority of the patients with CAP (59.61%) were below one year of age whereas the patients who developed empyema, were mainly (45.67%) between 2 to 5 years of age. Patients above 5 years of age having CAP (31.70%) and having repeated attacks of respiratory tract infection were most susceptible to develop empyema. Staphylococcus aureus was the most common organism found (40.35%) in this series. Vaccination, poverty and gender did not significantaffected the development of empyema among the patients of CAP. Antibiotic resistance had no role in the development of empyema. Ibuprofen may be a risk factor. All the patients were initially managed with tube thoracostomy and antibiotics. Forty-eight patients (42.10%) needed subsequently operative management. Three patients (2.63%) had fatal course in this series same as seen in patients of CAP (2%). Conclusions: Immunization against causative organism and modification of out patient treatment may affect the incidence of empyema in children and should be studied prospectively.

Lymphomatoid Granulomatosis of the Oropharynx

1980 ◽  
Vol 59 (4) ◽  
pp. 152-154 ◽  
Author(s):  
Saroj Gupta ◽  
O. P. Gupta
Keyword(s):  
Posterior Pharyngeal Wall ◽  
Lymphomatoid Granulomatosis ◽  
Arytenoid Cartilage ◽  
Vocal Cords ◽  
Pharyngeal Wall ◽  
Intestinal Involvement ◽  
Fatal Course ◽  
The Right ◽  
False Vocal ◽  
Midline Granuloma

A case of lymphomatoid granulomatosis presenting as midline granuloma has been reported because of the rarity and rapidly fatal course of the disease. The lesion primarily occupied the oropharynx, affecting the posterior pharyngeal wall, uvula, and posterior third of the tongue and extending on to the larynx to invade arytenoid cartilage, true and false vocal cords, and piriform fossa on the right side, with associated intestinal involvement.

Long terminal repeats of dwarf hamster endogenous retrovirus are highly diverged and do not maintain efficient transcription

Virology ◽  
1991 ◽  
Vol 181 (1) ◽  
pp. 367-370 ◽  
Author(s):  
Andrei T. Tikhonenko ◽  
Alla V. Polotskaya ◽  
Nikita S. Vassetzky ◽  
Tanya V. Golovkina ◽  
Andrei V. Gudkov
Keyword(s):  
Endogenous Retrovirus ◽  
Long Terminal Repeats ◽  
Dwarf Hamster ◽  
Terminal Repeats
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