scholarly journals A Substantia Innominata-Midbrain Circuit Controls a General Aggressive Response

2020 ◽  
Author(s):  
Zhenggang Zhu ◽  
Qingqing Ma ◽  
Hongbin Yang ◽  
Lu Miao ◽  
Lina Pan ◽  
...  
Keyword(s):  
Aggressive Response ◽  
Substantia Innominata

scholarly journals A substantia innominata-midbrain circuit controls a general aggressive response

Neuron ◽  
2021 ◽  
Author(s):  
Zhenggang Zhu ◽  
Qingqing Ma ◽  
Lu Miao ◽  
Hongbin Yang ◽  
Lina Pan ◽  
...  
Keyword(s):  
Aggressive Response ◽  
Substantia Innominata

scholarly journals Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator

2021 ◽  
Author(s):  
Elisavet Kaltsouni ◽  
Patrick M. Fisher ◽  
Manon Dubol ◽  
Steinar Hustad ◽  
Rupert Lanzenberger ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Negative Relationship ◽  
Premenstrual Dysphoric Disorder ◽  
Aggressive Response ◽  
Anterior Cingulate ◽  
Reproductive Age ◽  
Gonadal Hormone ◽  
Dorsal Anterior Cingulate Cortex ◽  
Response Condition ◽  
Receptor Modulator

AbstractPremenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their reproductive age. Altered sensitivity of cognitive-affective brain circuits to progesterone and its downstream metabolite allopregnanolone is suggested to underlie PMDD symptomatology. Core mood symptoms include irritability and anger, with aggression being the behavioral outcome of these symptoms. The present study sought to investigate the neural correlates of reactive aggression during the premenstrual phase in women with PMDD, randomized to a selective progesterone receptor modulator (SPRM) or placebo. Self-reports on the Daily Record of Severity of Problems were used to assess PMDD symptoms and gonadal hormone levels were measured by liquid chromatography tandem mass spectrometry. Functional magnetic resonance imaging was performed in 30 women with PMDD, while performing the point subtraction aggression paradigm. Overall, a high SPRM treatment response rate was attained (93%), in comparison with placebo (53.3%). Women with PMDD randomized to SPRM treatment had enhanced brain reactivity in the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex during the aggressive response condition. The fronto-cingulate reactivity during aggressive responses depended on treatment, with a negative relationship between brain reactivity and task-related aggressiveness found in the placebo but not the SPRM group. The findings contribute to define the role of progesterone in PMDD symptomatology, suggesting a beneficial effect of progesterone receptor antagonism, and consequent anovulation, on top-down emotion regulation, i.e., greater fronto-cingulate activity in response to provocation stimuli.

Is Dopamine a Neurotransmitter within the Ventral Pallidum/Substantia Innominata?

1991 ◽  
pp. 183-195 ◽  
Author(s):  
T. Celeste Napier ◽  
Mary Beth Muench ◽  
Renata J. Maslowski ◽  
George Battaglia
Keyword(s):  
Ventral Pallidum ◽  
Substantia Innominata

scholarly journals Email versus In-Person Audit Inquiry: Recent Research and Additional Survey Data

2018 ◽  
Vol 12 (2) ◽  
pp. A36-A44
Author(s):  
Aaron Saiewitz
Keyword(s):  
Survey Data ◽  
Aggressive Response ◽  
Relationship Building ◽  
Future Research ◽  
Email Communication ◽  
Audit Firms ◽  
Client Relationship ◽  
Client Behavior ◽  
Negative Feelings ◽  
Over Time

SUMMARY Recent research suggests that an auditor's choice to conduct audit inquiry via email versus in person can adversely impact both auditor and client behavior. In this study, I review recent research on this important topic, and I present additional survey-based evidence that describes how clients perceive auditor email versus in-person inquiries. I find that clients generally view auditors' in-person requests as more important and urgent than email requests, and clients feel they can more carefully craft their responses to support their company's preferred reporting position via email compared to in person. Further, clients expect that auditors will question an aggressive response more quickly in person than over email. Although audit partners have expressed concerns that email communication could impede auditor-client relationship building, I find no differences in how much clients like the auditor or in clients' willingness to work again with the auditor after receiving an email or in-person request. However, recent research suggests that email requests can lead to more negative feelings toward the auditor, which could affect the auditor-client relationship over time. I discuss implications for audit firms and provide suggestions for future research.

scholarly journals Meynert and the basal nucleus

2013 ◽  
Vol 7 (4) ◽  
pp. 435-438 ◽  
Author(s):  
Eliasz Engelhardt
Keyword(s):  
20Th Century ◽  
19Th Century ◽  
Basal Ganglion ◽  
Basal Nucleus ◽  
Cell Composition ◽  
Substantia Innominata ◽  
The 19Th Century ◽  
Considerable Body ◽  
The Brain

ABSTRACT Meynert described the "loop of the peduncular foot" (Schlinge des Hirnschenkelfusses), and its ganglion (Ganglion der Hirnschenkelschlinge) and related them to Reil's Substantia innominata and Gratiolet's Ansa peduncularis, from which he apparently built up his findings. Koelliker renamed the ganglion with the eponymous designation Meynert'sches Basalganglion (Meynert's basal ganglion), a name which endures to the present day, and described its topographical spread in relation to neighboring structures. Meynert and Koelliker also described aspects of cell composition of the ganglion (or nucleus) with a better account of the latter. Both, together with Reil and Gratiolet, were the outstanding personalities of the 19th century who performed the pioneering studies on basal formations of the forebrain. After these works, a considerable body of research appeared in the 20th century, with a focus on Meynert's basal nucleus and related structures. The development of further knowledge about these structures revealed their great importance in the activity of the brain, as evidenced in both normal and pathological states.

Ibotenic Acid-Induced Lesions of Substantia Innominata on Focal Limbic Seizures in Chronic Cats

1987 ◽  
Vol 41 (3) ◽  
pp. 508-509
Author(s):  
Masayuki Kunimoto ◽  
Shigeya Tanaka ◽  
Tatsuya Tanaka ◽  
Yukichi Yonemasu
Keyword(s):  
Ibotenic Acid ◽  
Limbic Seizures ◽  
Substantia Innominata
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