Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition

2020 ◽  
Author(s):  
Xingfa Han ◽  
Laura Burger ◽  
David Garcia-Galiano ◽  
Seokmin Sim ◽  
Susan Allen ◽  
...  
Keyword(s):  
Pubertal Transition

scholarly journals Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty

2021 ◽  
Author(s):  
Tiffany C. Ho ◽  
Anthony J. Gifuni ◽  
Ian H. Gotlib
Keyword(s):  
Pubertal Timing ◽  
Anterior Cingulate ◽  
Neural Systems ◽  
Hormonal Changes ◽  
Suicidal Thoughts ◽  
Social Stressors ◽  
And Behaviors ◽  
Suicidal Thoughts And Behaviors ◽  
Pubertal Transition

AbstractSuicide is the second leading cause of death among adolescents. While clinicians and researchers have begun to recognize the importance of considering multidimensional factors in understanding risk for suicidal thoughts and behaviors (STBs) during this developmental period, the role of puberty has been largely ignored. In this review, we contend that the hormonal events that occur during puberty have significant effects on the organization and development of brain systems implicated in the regulation of social stressors, including amygdala, hippocampus, striatum, medial prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex. Guided by previous experimental work in adults, we also propose that the influence of pubertal hormones and social stressors on neural systems related to risk for STBs is especially critical to consider in adolescents with a neurobiological sensitivity to hormonal changes. Furthermore, facets of the pubertal transition, such as pubertal timing, warrant deeper investigation and may help us gain a more comprehensive understanding of sex differences in the neurobiological and psychosocial mechanisms underlying adolescent STBs. Ultimately, advancing our understanding of the pubertal processes that contribute to suicide risk will improve early detection and facilitate the development of more effective, sex-specific, psychiatric interventions for adolescents.

Physical Changes During Pubertal Transition

Puberty ◽  
2016 ◽  
pp. 39-64 ◽  
Author(s):  
Ralitsa Robeva ◽  
Philip Kumanov
Keyword(s):  
Physical Changes ◽  
Pubertal Transition

scholarly journals Hypothalamic and Cell-Specific Transcriptomes Unravel a Dynamic Neuropil Remodeling in Leptin-Induced and Typical Pubertal Transition in Female Mice

iScience ◽  
2020 ◽  
Vol 23 (10) ◽  
pp. 101563
Author(s):  
Xingfa Han ◽  
Laura L. Burger ◽  
David Garcia-Galiano ◽  
Seokmin Sim ◽  
Susan J. Allen ◽  
...  
Keyword(s):  
Female Mice ◽  
Pubertal Transition

scholarly journals The impact of early neglect on defensive and appetitive physiology during the pubertal transition: A study of startle and postauricular reflexes

2015 ◽  
Vol 57 (3) ◽  
pp. 289-304 ◽  
Author(s):  
Karina Quevedo ◽  
Anna E. Johnson ◽  
Michelle M. Loman ◽  
Theresa Lafavor ◽  
Bao Moua ◽  
...  
Keyword(s):  
The Impact ◽  
Pubertal Transition

scholarly journals Resolution of Severe Anorexia Nervosa Associated with Gender Dysphoria (Dysphorexia) by Testosterone Therapy in Two Male Transgender Youth

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Francisco Javier Martinez Martin
Keyword(s):  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Hormone Therapy ◽  
Gender Dysphoria ◽  
Pubertal Development ◽  
Parental Consent ◽  
Testosterone Therapy ◽  
Transgender Youth ◽  
Limited Success ◽  
Pubertal Transition

Anorexia nervosa is a severe and potentially lethal eating disorder. In transgender youth with severe gender dysphoria, a severe eating disorder (proposed name: dysphorexia), coherent with anorexia nervosa may be triggered by the desire to avoid the cisgender pubertal transition. In these patients, gender-affirming hormone therapy can be extremely effective. We report hereby the cases of two female-to-male transsexual patients with severe gender dysphoria whose anorexia nervosa was related to their pubertal development and who promptly recovered when they started gender-affirming hormone therapy with testosterone, after very limited success with standard psychotherapy and pharmacotherapy for anorexia nervosa. Our patients could not access pubertal suppression due to lack of parental consent in one case and failure to express the conflict in the other. We postulate that avoiding the cisgender pubertal transition with GnRH agonist treatment might also be able to prevent the development of dysphorexia.

scholarly journals Evolution of the Krebs cycle during the prepubertal‐pubertal transition in rat mammary gland

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Antonio Piras ◽  
Praveen Vayalil ◽  
Landon Wilson ◽  
Hui‐Chien Kuo ◽  
Michael Crowley ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Krebs Cycle ◽  
Rat Mammary Gland ◽  
Pubertal Transition
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