A Fractional Order COVID-19 Epidemic Transmission Model: Stability Analysis and Optimal Control

2020 ◽  
Author(s):  
Meghadri Das ◽  
G.P. Samanta
Mathematics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 703
Author(s):  
Meghadri Das ◽  
Guruprasad Samanta ◽  
Manuel De la Sen

In this work, a fractional-order synthetic drugs transmission model with psychological addicts has been proposed along with psychological treatment. The effects of synthetic drugs are deadly and sometimes even violent. We have studied the local and global stability of the model with different criterion. The existence and uniqueness criterion along with positivity and boundedness of the solutions have also been established. The local and global stabilities are decided by the basic reproduction number R0. We have also analyzed the sensitivity of parameters. An optimal control problem has been formulated by controlling psychological addiction and analyzed by the help of Pontryagin maximum principle. These results are verified by numerical simulations.


2021 ◽  
pp. 1-1
Author(s):  
Majid Ghorbani ◽  
Mahsan Tavakoli-Kakhki ◽  
Aleksei Tepljakov ◽  
Eduard Petlenkov ◽  
Arash Farnam ◽  
...  

2020 ◽  
Vol 23 (6) ◽  
pp. 1783-1796
Author(s):  
Neelam Singha

Abstract In this article, we aim to analyze a mathematical model of tumor growth as a problem of fractional optimal control. The considered fractional-order model describes the interaction of effector-immune cells and tumor cells, including combined chemo-immunotherapy. We deduce the necessary optimality conditions together with implementing the Adomian decomposition method on the suggested fractional-order optimal control problem. The key motive is to perform numerical simulations that shall facilitate us in understanding the behavior of state and control variables. Further, the graphical interpretation of solutions effectively validates the applicability of the present analysis to investigate the growth of cancer cells in the presence of medical treatment.


2018 ◽  
Vol 12 (3) ◽  
pp. 359-367 ◽  
Author(s):  
Yassine Boukal ◽  
Mohamed Darouach ◽  
Michel Zasadzinski ◽  
Nour-Eddine Radhy

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