Critically Ill COVID-19 Patients with Acute Kidney Injury Have Reduced Renal Blood Flow and Perfusion Despite Preserved Cardiac Function; A Case-Control Study Using Contrast Enhanced Ultrasound

2020 ◽  
Author(s):  
Jame Watchorn ◽  
Dean Y Huang ◽  
Jennifer Joslin ◽  
Kate Bramham ◽  
Sam Hutchings
Keyword(s):  
Acute Kidney Injury ◽  
Blood Flow ◽  
Cardiac Function ◽  
Renal Blood Flow ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Control Study

scholarly journals Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041543
Author(s):  
Keiko Ikuta ◽  
Shunsaku Nakagawa ◽  
Kenji Momo ◽  
Atsushi Yonezawa ◽  
Kotaro Itohara ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Renal Diseases ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

ObjectivesThis study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins or fluoroquinolones) was associated with an increased risk of acute kidney injury (AKI).DesignA nested case–control study.SettingA health insurance claims database constructed by the Japan Medical Data Center.ParticipantsPatients were eligible if they were prescribed a PPI, NSAID and antibiotic at least once between January 2005 and June 2017. The patients who were new PPI users and did not have any history of renal diseases before cohort entry were included (n=219 082). The mean age was 45 and 44% were women.InterventionsCurrent use of PPIs, NSAIDs, or antibiotics.Primary outcome measuresAcute kidney injury.ResultsDuring a mean follow-up of 2.4 (SD, 1.7) years, 317 cases of AKI were identified (incidence rate of 6.1/10 000 person-years). The current use of PPIs was associated with a higher risk of AKI compared with past PPI use (unadjusted OR, 4.09; 95% CI, 3.09 to 5.44). The unadjusted ORs of AKI for the current use of PPIs with NSAIDs, cephalosporins and fluoroquinolones, compared with the current use of PPIs alone, were 3.92 (95% CI, 2.40 to 6.52), 2.57 (1.43 to 4.62) and 3.08 (1.50 to 6.38), respectively. The effects of concurrent use of PPIs with NSAIDs, cephalosporins or fluoroquinolones remain significant in the adjusted model. The analyses on absolute risk of AKI confirmed the results from the nested case–control study.ConclusionsConcomitant use of NSAIDs with PPIs significantly increased the risk for AKI. Moreover, the results suggested that concomitant use of cephalosporins or fluoroquinolones with PPIs was associated with increased risk of incident AKI.

scholarly journals Correction to: Is metformin associated with acute kidney injury? A case–control study of patients with type 2 diabetes admitted with acute infection

2020 ◽  
Author(s):  
Philip Andreas Schytz ◽  
Anders Bonde Nissen ◽  
Kristine Hommel ◽  
Morten Schou ◽  
Karl Emil Nelveg-Kristensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Acute Kidney Injury ◽  
Case Control Study ◽  
Acute Infection ◽  
Kidney Injury ◽  
Case Control ◽  
Control Study

Acute kidney injury as a risk factor of hyperactive delirium: A case control study

2020 ◽  
Vol 55 ◽  
pp. 194-197 ◽  
Author(s):  
RYY Wan ◽  
CA McKenzie ◽  
D Taylor ◽  
L Camporota ◽  
M Ostermann
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Control Study

scholarly journals Anemia, Blood Transfusion, and Filter Life Span in Critically Ill Patients Requiring Continuous Renal Replacement Therapy for Acute Kidney Injury: A Case-Control Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Hasan M. Al-Dorzi ◽  
Nora Ali Alhumaid ◽  
Nouf Hamad Alwelyee ◽  
Nouf Mubark Albakheet ◽  
Ramah Ibrahim Nazer ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Blood Transfusion ◽  
Life Span ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Hemoglobin Level ◽  
Filter Life ◽  
Control Study

Background. Filter clotting is frequent during continuous renal replacement therapy (CRRT), which increases anemia risk. We studied anemia and blood transfusion in critically ill patients requiring CRRT for acute kidney injury and assessed the relationship between CRRT filter life span and PRBC transfusion. Methods. A case-control study was conducted at a tertiary-care intensive care unit (ICU) where CRRT cases were matched with controls for age, gender, admission category, and severity of illness. Daily hemoglobin levels, blood transfusions, and life span of CRRT filter were noted. CCRT patients were categorized according to the median of the filter life span (20 hours). Results. Ninety-five cases and 102 controls were enrolled. The hemoglobin level on admission was similar in the two groups, yet cases had significantly lower hemoglobin levels than controls (72.8 ± 15.3 versus 82.5 ± 20.7 g/L, p<0.001) during ICU stay. Anemia <70 g/L occurred in 50% of cases and 19% of controls (p<0.001). Most (56.3%) cases were transfused compared with 29.9% for controls (p<0.001) with higher number of transfused packed red blood cell (PRBC) units in cases (2.6 ± 4.0 versus 1.5 ± 3.2 units per patient, p=0.03). Patients with shorter versus longer filter life had similar hemoglobin level in the first 7 days of CRRT with no difference in PRBC transfusion requirement. Prefilter heparin use and hemodialysis access location were not associated with longer filter life span. The mortality was similar in patients with shorter versus longer filter life. Conclusions. CRRT in ICU was associated with larger drop in hemoglobin and more PRBC transfusion. Shorter (<20 hours) versus longer CCRT filter life was not associated with increased PRBC transfusion.

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