Lung Endothelial Cell Injury in COVID-19: Inhibition of TRPV4 As a Promising and Feasible Approach

2020 ◽  
Author(s):  
Wolfgang Kuebler ◽  
Sven-Eric Jordt ◽  
Wolfgang Liedtke
Keyword(s):  
Endothelial Cell ◽  
Cell Injury ◽  
Endothelial Cell Injury

507-P: Changes of miR-223-3p May Play an Important Role in Renal Endothelial Cell Injury of Diabetes Kidney Disease (DKD)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 507-P
Author(s):  
RONG LI ◽  
LIN JIE ◽  
JINGMEI LUO ◽  
ZHONGCE YANG ◽  
LIHUA ZHANG
Keyword(s):  
Endothelial Cell ◽  
Kidney Disease ◽  
Cell Injury ◽  
Endothelial Cell Injury

scholarly journals The severity of glomerular endothelial cell injury is associated with infiltrating macrophage heterogeneity in endocapillary proliferative glomerulonephritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Momoko Arai ◽  
Akiko Mii ◽  
Tetsuya Kashiwagi ◽  
Akira Shimizu ◽  
Yukinao Sakai
Keyword(s):  
Endothelial Cell ◽  
Cell Injury ◽  
Cell Damage ◽  
Computer Assisted ◽  
Endothelial Cell Injury ◽  
Glomerular Capillary ◽  
Luminal Area ◽  
Endocapillary Proliferative Glomerulonephritis ◽  
Cell Phenotypes ◽  
Schonlein Purpura

AbstractEndocapillary proliferation occurs in various types of glomerulonephritis (GN), with varying prognoses. We examined 42 renal biopsy samples representing endocapillary proliferative lesions from post-streptococcal acute GN (PSAGN), Henoch–Schönlein purpura nephritis (HSPN), and lupus nephritis (LN). In PSAGN, the glomerular capillary network was maintained, although severe lesions displayed dots or short, curved lines, indicating CD34-positive capillaries and suggesting capillary obstruction. Conversely, patients with LN and HSPN displayed obstruction of CD34-positive capillaries with dissociation from the glomerular basement membrane even in mild lesions. According to computer-assisted morphologic analysis, the cell density did not differ between the diseases. However, in PSAGN, the number of capillary loops was significantly increased, with a larger glomerular capillary luminal area than in the other groups. In addition, the number and frequency of CD163-positive cells (M2 macrophages) tended to be higher in PSAGN, while there were no significant differences in the number of CD68-positive (total) macrophages. These results indicate that in PSAGN, endothelial cell damage is less severe, and angiogenesis may be promoted. The severity of endothelial cell injury in each disease may be associated with differences in infiltrating inflammatory cell phenotypes.

Prognostic Significance of Plasma Hepatocyte Growth Factor in Sepsis

2021 ◽  
pp. 088506662199342
Author(s):  
Fei Peng ◽  
Chenglong Liang ◽  
Wei Chang ◽  
Qin Sun ◽  
Jianfeng Xie ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Injury ◽  
Prognostic Significance ◽  
Trial Registration ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pulmonary Vascular Permeability ◽  
Endothelial Cell Injury ◽  
Hepatocyte Growth

Background: To assess any correlation of plasma hepatocyte growth factor (HGF) levels with relevant endothelial cell injury parameters and determine the prognostic value in septic patients. Methods: A prospective, observational study was conducted in patients with sepsis admitted to the Department of Critical Care Medicine at the Zhongda Hospital from November 2017 to March 2018. Plasma HGF levels were measured by enzyme-linked immunosorbent assay in the first 24 h after admission (day 1) and on day 3. The primary endpoint was defined as all-cause 28-day mortality. Furthermore, we analyzed the correlation of HGF with relevant endothelial cell injury markers. Results: Eighty-six patients admitted with sepsis were included. HGF levels of nonsurvivors were elevated compared to those of survivors on day 1 (1940.62 ± 74.66 pg/mL vs. 1635.61 ± 47.49 pg/mL; P = 0.002) and day 3 (1824.82 ± 137.52 pg/mL vs. 1309.77 ± 83.49 pg/mL; P = 0.001) and showed a strong correlation with von Willebrand factor (r = 0.45, P < 0.0001), lactate (r = 0.35, P = 0.0011), pulmonary vascular permeability index (r = 0.38, P = 0.0241), first 24 h fluid administration (r = 0.38, P < 0.0001), and sequential organ failure assessment score (r = 0.40, P = 0.0001). Plasma HGF levels were able to prognostically discriminate between survivors and nonsurvivors on day 1 (AUC: 0.72, 95%CI: 0.60-0.84) and day 3 (AUC: 0.77, 95%CI: 0.63-0.91). Conclusions: HGF levels are associated with sepsis and correlated with established markers of endothelial cell injury. Elevated HGF levels in sepsis patients are an efficient indicator of poor prognosis. Trial registration: The study was registered in Clinical Trial (Registration Number: NCT02883231).

scholarly journals Kaempferol alleviates human endothelial cell injury through circNOL12/miR-6873-3p/FRS2 axis

2021 ◽  
Vol 137 ◽  
pp. 111419
Author(s):  
Shuangzhan Li ◽  
Meihua Hao ◽  
Taisheng Wu ◽  
Zixuan Wang ◽  
Xicheng Wang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Injury ◽  
Human Endothelial Cell ◽  
Endothelial Cell Injury

Laser-induced shock wave endothelial cell injury

2000 ◽  
Vol 26 (4) ◽  
pp. 364-375 ◽  
Author(s):  
Anders Sond�n, ◽  
Bengt Svensson ◽  
Nils Roman ◽  
Henric �stmark ◽  
Bo Brismar ◽  
...  
Keyword(s):  
Shock Wave ◽  
Endothelial Cell ◽  
Cell Injury ◽  
Endothelial Cell Injury

Circ-USP9X inhibition reduces ox-LDL-induced endothelial cell injury via the miR-599/CLIC4 axis

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Huaiyu Peng ◽  
Jihu Sun ◽  
Yi Li ◽  
Ye Zhang ◽  
Yongjin Zhong
Keyword(s):  
Endothelial Cell ◽  
Cell Injury ◽  
Endothelial Cell Injury
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