Gene Knockout in a Cephalopod

2020 ◽  
Author(s):  
Karen Crawford ◽  
Caroline B. Albertin ◽  
Juan Felipe Diaz Quiroz ◽  
Namrata Ahuja ◽  
Kristen M. Koenig ◽  
...  
Keyword(s):  
Gene Knockout

Production of prion gene knockout cow to prevent spontaneous bovine spongiform encephalopathy

2014 ◽  
Author(s):  
Noboru Manabe ◽  
Ichiro Onoyama ◽  
Junyou Li ◽  
Yutaka Sendai ◽  
Yoshito Aoyagi
Keyword(s):  
Bovine Spongiform Encephalopathy ◽  
Gene Knockout ◽  
Spongiform Encephalopathy ◽  
Prion Gene

Effect of taste receptor protein T1R3 on the development of islet tissue of the murine pancreas

2019 ◽  
Vol 484 (1) ◽  
pp. 117-120
Author(s):  
V. O. Murovets ◽  
E. A. Sozontov ◽  
T. G. Zachepilo
Keyword(s):  
Parent Strain ◽  
Gene Knockout ◽  
Taste Receptor ◽  
Morphological Characteristics ◽  
Sweet Taste ◽  
Pancreatic Tissue ◽  
Receptor Protein ◽  
Gene Encoding ◽  
Islet Tissue ◽  
Knockout Animals

Protein T1R3, the main subunit of sweet, as well as amino acid, taste receptor, is expressed in the epithelium of the tongue and gastro intestinal tract, in β–cells of the pancreas, hypothalamus, and numerous other organs. Recently, convincing witnesses of T1R3 involvement in control of carbohydrate and lipid metabolism, and control of production of incretines and insulin, have been determined. In the study on Tas1r3-gene knockout mouse strain and parent strain C57Bl/6J as control, priority data concerning the effect of T1R3 on the morphological characteristics of Langerhans islets in the pancreas, are obtained. In Tas1r3 knockout animals, it is found that the size of the islets and their density in pancreatic tissue are reduced, as compared to the parent strain. Additionally, a decrease of expression of active caspase-3 in islets of gene-knockouts is demonstrated. The obtained data show that the lack of a functional, gene encoding sweet-taste receptor protein causes a dystrophy of the islet tissue and associates to the development of pathological changes in the pancreas specific to type-2 diabetes and obesity in humans.

Production of myostatin gene knockout Wuzhishan miniature pig fibroblasts with zinc-finger nucleases

2013 ◽  
Vol 35 (6) ◽  
pp. 778-785
Author(s):  
Sui-Zhong CAO ◽  
Cheng-He YUE ◽  
Xi-Rui LI ◽  
Chong FENG ◽  
Chuan LONG ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Gene Knockout ◽  
Zinc Finger Nucleases ◽  
Miniature Pig ◽  
Myostatin Gene

Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice

2002 ◽  
Vol 2 (6) ◽  
pp. 815-822 ◽  
Author(s):  
Caroline Lagneux ◽  
Michael Bader ◽  
João B. Pesquero ◽  
Pierre Demenge ◽  
Christophe Ribuot
Keyword(s):  
Myocardial Ischemia ◽  
Knockout Mice ◽  
Gene Knockout ◽  
B1 Receptors ◽  
Gene Knockout Mice ◽  
Pharmacological Blockade

Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice

2006 ◽  
Vol 51 (3) ◽  
pp. 612-622 ◽  
Author(s):  
Jalal Izadi Mobarakeh ◽  
Kazuhiro Takahashi ◽  
Shinobu Sakurada ◽  
Atsuo Kuramasu ◽  
Kazuhiko Yanai
Keyword(s):  
Knockout Mice ◽  
Gene Knockout ◽  
Receptor Gene ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Antinociceptive Effects ◽  
Gene Knockout Mice

scholarly journals Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout

2017 ◽  
Author(s):  
Jingjing Zhang ◽  
Junli Zhao ◽  
Xiaojing Zheng ◽  
Kai Cai ◽  
Qinwen Mao ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Cell Model ◽  
Gene Knockout
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