Frequency, Onset and Clinical Impact of Neurological Symptoms in COVID-19 Disease: A Cohort Study on 576 Confirmed Cases

2020 ◽  
Author(s):  
David García-Azorín ◽  
F. Javier Trigos-Arrieta ◽  
Enrique Martínez-Pías ◽  
Isabel Hernández-Pérez ◽  
Gonzalo Valle-Peñacoba ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Impact ◽  
Neurological Symptoms

ROLE OF COMPUTED TOMOGRAPHY SCAN IN EVALUATION OF NEUROLOGICAL MANIFESTATIONS IN COVID 19 POSITIVE PATIENTS AND ITS CORRELATION WITH D-DIMER VALUE AND GCS: A RETROSPECTIVE COHORT STUDY IN A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

2021 ◽  
pp. 17-21
Author(s):  
Debraj Saha ◽  
Aarti Anand ◽  
Jawahar Rathod ◽  
Prajwaleet Gour ◽  
Shivprasad Jaybhay ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Stroke ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Neurological Symptoms ◽  
Government Medical College ◽  
Stroke Patients ◽  
Medical College ◽  
Neuro Imaging ◽  
D Dimer

Objective: To investigate the incidence and spectrum of neuroimaging ndings and their prognostic role in hospitalized COVID-19 patients in Government Medical College Nagpur along with their correlation with D-Dimer Values and GCS . Methods: This is a retrospective cohort study of 774 COVID-19 conrmed patients admitted to Government Medical College st st Nagpur between 1 April 2020 and 31 October 2020. Clinical data were extracted from electronic medical records, and particularly data of all neurological symptoms were extracted from the imaging reports. Four neuro-radiologists evaluated all neuroimaging studies for acute neuroimaging ndings related to COVID-19. Plasma D-dimer levels were measured using a particle-enhanced, immunoturbidimetric assay on admission in the 116 patients who came for evaluation of neurological symptoms. Moreover ,the patients were classied into different groups as mild, moderate and severe based on their GCS scores and was assessed with respect to their neuro-imaging ndings. Results: 15 % of the admitted patients suffered from neurological symptoms. Acute stroke was the most common nding in the patients with positive neuroimaging ndings resulting in 34.4% of the patients with positive neuroimaging ndings. Other ndings were subacute infarcts (13.8%), Chronic lacunar infarcts (20.6%) , Intraparenchymal hemorrhage in 10.4 %, hypertensive encephalopathy in 7 % and subarachanoid hemorrhage in 3.4 %. Plasma median D-dimer levels were signicantly (P฀ =฀ 0.000) higher in Acute stroke patients as compared to COVID 19 positive patients who had negative CT scan imaging features(0.88; interquartile range [IQR], 0.28–2.11 mg/L and 0.31; IQR, 0.17–0.74 mg/L). Patients who have positive neuroimaging ndings presented with a lower GCS whereas patients who had negative neuroimaging ndings presented with a higher GCS. Conclusions: Our study demonstrates acute stroke is the most common neuroloimaging nding in hospitalized COVID 19 Patients. Moreover D-Dimer values are highly predictive of acute ischemic stroke. Patients with positive neuro-imaging ndings have poor GCS scores.

scholarly journals Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

The Lancet ◽  
2020 ◽  
Vol 395 (10241) ◽  
pp. 1907-1918 ◽  
Author(s):  
Nicole M Kuderer ◽  
Toni K Choueiri ◽  
Dimpy P Shah ◽  
Yu Shyr ◽  
Samuel M Rubinstein ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Impact ◽  
Patients With Cancer

scholarly journals The social and clinical impact of the COVID‐19 epidemic on the Strasbourg lung transplant cohort: A single‐center retrospective cohort study

2020 ◽  
Vol 34 (12) ◽  
Author(s):  
Benjamin Renaud‐Picard ◽  
Floriane Gallais ◽  
Marianne Riou ◽  
Eva Chatron ◽  
Tristan Degot ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Lung Transplant ◽  
Clinical Impact ◽  
Single Center ◽  
The Social

scholarly journals 447: Investigating the clinical impact of chronic Achromobacter spp. infection in cystic fibrosis: A cohort study

2021 ◽  
Vol 20 ◽  
pp. S211
Author(s):  
M. Drapeau ◽  
Z. Zysman-Colman ◽  
A. Lavoie ◽  
A. Blanchard ◽  
E. Vallieres
Keyword(s):  
Cystic Fibrosis ◽  
Cohort Study ◽  
Clinical Impact

scholarly journals Clinical Impact of the Administration of FOLFIRINOX Beyond Six Months in Advanced Pancreatic Adenocarcinoma: A Cohort Study

Cureus ◽  
2021 ◽  
Author(s):  
Cornelia Nitipir ◽  
Radu Vrabie ◽  
Andreea Ioana Parosanu ◽  
Raluca Tulin ◽  
Bogdan Cretu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pancreatic Adenocarcinoma ◽  
Clinical Impact ◽  
Advanced Pancreatic Adenocarcinoma

Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study

Leukemia ◽  
2020 ◽  
Vol 34 (12) ◽  
pp. 3256-3268 ◽  
Author(s):  
Simon Husby ◽  
Francesco Favero ◽  
Christian Nielsen ◽  
Betina S. Sørensen ◽  
John Bæch ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Clinical Impact ◽  
National Population ◽  
Clonal Hematopoiesis

scholarly journals Early Failures After Lumbar Discectomy Surgery: An Analysis of 62 690 Patients

2020 ◽  
pp. 219256822093540
Author(s):  
Andre M. Samuel ◽  
Kyle Morse ◽  
Francis Lovecchio ◽  
Noor Maza ◽  
Avani S. Vaishnav ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Lumbar Fusion ◽  
Lumbar Discectomy ◽  
Neurological Symptoms ◽  
Improvement Program ◽  
Increased Risk ◽  
Early Failures

Study Design: Retrospective cohort study. Objective: To determine the rate of early failures (readmission or reoperation for new or recurrent pain/neurological symptoms) within 30 days after lumbar discectomy and identify associated risk factors. Methods: A retrospective cohort study was conducted of patients undergoing lumbar discectomy in the National Surgical Quality Improvement Program database between 2013 and 2017. Rates of readmission for new or recurrent symptoms or reoperation for revision discectomy or fusion within 30 days postoperatively were measured and correlated with risk factors. Results: In total 62 690 patients were identified; overall rate of readmission within 30 days was 3.3%, including 1.2% for pain or neurological symptoms. Populations at increased risk of readmission were those with 3 or more levels of treatment (2.0%, odds ratio [OR] 2.8%, P < .01), age >70 years (1.8%, OR 1.6, P < .01), class 3 obesity (1.5%, OR 1.4, P = .04), and female gender (1.4%, OR 1.2, P = .02). The overall rate of reoperation within 30 days was 2.2%, including 1.2% for revision decompression or lumbar fusion surgery. Populations at increased risk of reoperation were revision discectomies (1.4%, OR 1.7, P < .01) and females (1.1%, OR 1.4, P < 0.01). Extraforaminal discectomies were associated with lower rates of readmission (0.7%, OR 0.6, P = 0.02) and reoperation (0.4%, OR 0.4, P = .01). Conclusions: Early failures after lumbar discectomy surgery are rare. However, certain subpopulations are associated with increased rates of early failure: obesity, multilevel surgery, females, and revision discectomies.

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