scholarly journals High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision

2020 ◽  
Author(s):  
Thomas Baranek ◽  
Kevin Lebrigand ◽  
Carolina de Amat Herbozo ◽  
Loïc Gonzalez ◽  
Gemma Bogard ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Developmental Trajectories ◽  
Inkt Cell ◽  
High Dimensional ◽  
Cell Analysis ◽  
Fate Decision

scholarly journals High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision

Cell Reports ◽  
2020 ◽  
Vol 32 (10) ◽  
pp. 108116 ◽  
Author(s):  
Thomas Baranek ◽  
Kevin Lebrigand ◽  
Carolina de Amat Herbozo ◽  
Loïc Gonzalez ◽  
Gemma Bogard ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Developmental Trajectories ◽  
Inkt Cell ◽  
High Dimensional ◽  
Cell Analysis ◽  
Fate Decision

scholarly journals High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision

2020 ◽  
Author(s):  
Thomas Baranek ◽  
Kevin Lebrigand ◽  
Carolina de Amat Herbozo ◽  
Loïc Gonzalez ◽  
Gemma Bogard ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Developmental Trajectories ◽  
Inkt Cell ◽  
Immune Functions ◽  
Inkt Cells ◽  
Sequence Of Events ◽  
Branching Point ◽  
Fate Decision ◽  
Biological Methods

SummaryCD1d-restricted invariant Natural Killer T (iNKT) cells represent a unique class of T lymphocytes endowed with potent regulatory and effector immune functions. Although these functions are acquired during thymic ontogeny, the sequence of events that give rise to discrete effector subsets remains unclear. Using an unbiased single-cell transcriptomic analysis combined with functional assays, we revealed an unappreciated diversity among thymic iNKT cells, especially among iNKT1 cells. Mathematical modelling and biological methods unravelled a developmental map whereby iNKT2 cells constitute a transient branching point towards the generation of iNKT1 and iNKT17 cells, which reconciles the two previously proposed models. In addition, we identified the transcription co-factor Four-and-a-half LIM domains protein 2 (FHL2) as a critical cell-intrinsic regulator of iNKT1 specification. Thus, these data illustrate the changing transcriptional network that guides iNKT cell effector fate.

scholarly journals High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

2018 ◽  
Vol 24 (2) ◽  
pp. 144-153 ◽  
Author(s):  
Carsten Krieg ◽  
Malgorzata Nowicka ◽  
Silvia Guglietta ◽  
Sabrina Schindler ◽  
Felix J Hartmann ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
High Dimensional ◽  
Cell Analysis

scholarly journals High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells

2021 ◽  
Author(s):  
Ke-Yue Ma ◽  
Alexandra A. Schonnesen ◽  
Chenfeng He ◽  
Amanda Y. Xia ◽  
Eric Sun ◽  
...  
Keyword(s):  
T Cells ◽  
Single Cell ◽  
High Throughput ◽  
Cd8 T Cells ◽  
Single Cell Analysis ◽  
High Dimensional ◽  
Cell Analysis

scholarly journals Exploration of Cell Development Pathways through High-Dimensional Single Cell Analysis in Trajectory Space

iScience ◽  
2020 ◽  
Vol 23 (2) ◽  
pp. 100842 ◽  
Author(s):  
Denis Dermadi ◽  
Michael Bscheider ◽  
Kristina Bjegovic ◽  
Nicole H. Lazarus ◽  
Agata Szade ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Cell Development ◽  
High Dimensional ◽  
Cell Analysis ◽  
Trajectory Space

scholarly journals The end of omics? High dimensional single cell analysis in precision medicine

2019 ◽  
Vol 49 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Edoardo Galli ◽  
Ekaterina Friebel ◽  
Florian Ingelfinger ◽  
Susanne Unger ◽  
Nicolás Gonzalo Núñez ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Single Cell ◽  
Single Cell Analysis ◽  
High Dimensional ◽  
Cell Analysis
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