PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

2020 ◽  
Author(s):  
Erin D. Lucas ◽  
Johnathon B. Schafer ◽  
Jennifer Matsuda ◽  
Madison Kraus ◽  
Matthew A. Burchill ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Reverse Signaling ◽  
Skin Immunity ◽  
Dendritic Cell Migration

scholarly journals PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

Cell Reports ◽  
2020 ◽  
Vol 33 (2) ◽  
pp. 108258
Author(s):  
Erin D. Lucas ◽  
Johnathon B. Schafer ◽  
Jennifer Matsuda ◽  
Madison Kraus ◽  
Matthew A. Burchill ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Reverse Signaling ◽  
Skin Immunity ◽  
Dendritic Cell Migration

scholarly journals Regulation of Intestinal Dendritic Cell Migration and Activation by Plasmacytoid Dendritic Cells, TNF-α and Type 1 IFNs after Feeding a TLR7/8 Ligand

2006 ◽  
Vol 176 (9) ◽  
pp. 5205-5212 ◽  
Author(s):  
Ulf Yrlid ◽  
Simon W. F. Milling ◽  
Joanna L. Miller ◽  
Sian Cartland ◽  
Christopher D. Jenkins ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Tnf Α ◽  
Dendritic Cell Migration

scholarly journals Vimentin provides target search efficiency and mechanical resilience for dendritic cell migration

2020 ◽  
Author(s):  
Luiza Da Cunha Stankevicins ◽  
M. Reza Shaebani ◽  
Doriane Vesperini ◽  
Marta Urbanska ◽  
Daniel A. D. Flormann ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Cell Stiffness ◽  
Search Efficiency ◽  
Mechanical Stiffness ◽  
Target Search ◽  
Dendritic Cell Migration

AbstractDendritic cells use amoeboid migration to pass through confined tissues to reach the lymph nodes, and this homing function is crucial for immune responses. The underlying mechanisms for this type of migration remain unknown. As vimentin intermediate filaments regulate adhesion-dependent migration, we analyzed whether they have a similar effect on amoeboid migration. We show that lack of vimentin impairs amoeboid migration in vitro in confined environments, and blocks lymph-node homing in mice in vivo. Importantly, we show that vimentin-deficient dendritic cells have a lower coupling factor between cell speed and persistence and reduced target search efficiency (e.g., finding a pathogen, or another cell). These data show that the characteristics of vimentin in its dynamic regulation of cell stiffness and load-bearing, and also elastic capacity, appear to explain the coupling between their migratory ability and search efficiency. Taken together, these data show that vimentin provides the specific mechano-dynamics required for dendritic cell migration and for efficient target searching.Summary statementVimentin contributes to the mechanical stiffness of cells required for amoeboid cell migration through confined spaces, and improves cell-search efficiency. Vimentin-deficient cells migrate more slowly and their migration speed is less coupled to persistence compared to control cells.

scholarly journals Prostaglandin E2 Inhibits Prostate Cancer Progression by Countervailing Tumor Microenvironment-Induced Impairment of Dendritic Cell Migration through LXRα/CCR7 Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Kuang Youlin ◽  
He Weiyang ◽  
Liang Simin ◽  
Gou Xin
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Tumor Microenvironment ◽  
Cancer Progression ◽  
Prostaglandin E ◽  
Prostate Cancer Progression ◽  
Dendritic Cell Migration

Migration and homing of dendritic cells (DCs) to lymphoid organs are quite crucial for T cell-induced immune response against tumor. However, tumor microenvironment can make some tumor cells escape immune response by impairing DC migration. Prostaglandin E2 (PGE2) plays important roles in initiating and terminating inflammatory responses. In this study, we investigated whether PGE2 could inhibit murine prostate cancer progression by countervailing tumor microenvironment-induced impairment of dendritic cell migration. We found that murine prostate cancer cell line RM-1-conditioned medium impaired chemotactic movement of marrow-derived DCs and splenic cDCs toward CC chemokine receptor-7 (CCR7) ligand CCL19 in vitro and migration to draining lymph gland in vivo. Meanwhile, it also induced LXRα activation and CCR7 inhibition on maturing DCs. However, the treatment of PGE2 rescued this impairment of DC migration with upregulation of CCR7 and inhibition of LXRα. Further, it was observed that PGE2 also increased MMP9 expression and activated Notch1 signaling on DCs. In RM-1-bearing mouse model, PGE2 treatment was identified to inhibit tumor growth and induce more tumor-infiltrating T cells and CD11c dendritic cells in tumor sites. Therefore, our findings may demonstrate a new perspective for therapeutic interventions on prostate cancer immunoescape.

scholarly journals The HGF Receptor/Met Tyrosine Kinase Is a Key Regulator of Dendritic Cell Migration in Skin Immunity

2012 ◽  
Vol 189 (4) ◽  
pp. 1699-1707 ◽  
Author(s):  
Jea-Hyun Baek ◽  
Carmen Birchmeier ◽  
Martin Zenke ◽  
Thomas Hieronymus
Keyword(s):  
Cell Migration ◽  
Dendritic Cell ◽  
Tyrosine Kinase ◽  
Skin Immunity ◽  
Dendritic Cell Migration
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