Mortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea:  A Population-Based Comparative Study

2020 ◽  
Author(s):  
Hyewon Lee ◽  
Woojae Myung ◽  
Eun-Mi Lee ◽  
Hyekyeong Kim ◽  
Byung Woo Jhun
Keyword(s):  
Prognostic Factors ◽  
Comparative Study ◽  
Mycobacterial Infection ◽  
Population Based ◽  
Nontuberculous Mycobacterial Infection

Mortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea: A Population-based Comparative Study

2020 ◽  
Author(s):  
Hyewon Lee ◽  
Woojae Myung ◽  
Eun-Mi Lee ◽  
Hyekyeong Kim ◽  
Byung Woo Jhun
Keyword(s):  
General Population ◽  
Multivariable Analysis ◽  
Mycobacterial Infection ◽  
Population Based ◽  
Cumulative Survival ◽  
Survival Probabilities ◽  
International Classification Of Disease ◽  
Nontuberculous Mycobacterial Infection ◽  
Korean National Health Insurance

Abstract Background Population-based studies on the mortality burden of nontuberculous mycobacteria (NTM) infection are lacking. We compared the long-term mortality of NTM-infected patients with tuberculosis (TB)-patients and the general population, and investigated mortality-associated factors. Methods We analyzed nationwide-data from the Korean National Health Insurance and Korea-Statistical Office between 2002 and 2017. NTM infection was identified using the International Classification of Disease, Tenth Revision code, with one-to-one matching to TB patients and general population controls. Results A total of 530 401 individuals were analyzed, including 183 267 with NTM infections; 166 666 with TB; and 180 468 controls. The overall 6-, 10-, and 14-year cumulative survival probabilities in the NTM group were 86.3%, 80.8%, and 77.1%, respectively, which were significantly lower than those of the TB or control groups (log-rank P < .0001). In cases of NTM and TB coinfection, the overall 6-, 10-, and 14-year cumulative survival probabilities were 75.1%, 65.4%, and 57.0%, respectively. Multivariable analysis indicated that old age, male gender, province, and various respiratory or nonrespiratory comorbidities were significantly associated with mortality of NTM infection. The use of a macrolide (more than 1 year) negatively correlated with mortality of NTM infection (adjusted hazard ratio [aHR] 0.61, 95% confidence interval [CI] .53–.71), regardless of azithromycin (aHR 0.60, 95% CI .43–.85) or clarithromycin use (aHR 0.63, 95% CI .53–.75). Conclusions NTM-infected patients had poor prognosis when compared to TB patients or the general population, especially for NTM and TB coinfection. NTM mortality was associated with certain demographic characteristics, but long-term use of macrolides may provide survival benefits.

scholarly journals Increased Incidence of Cutaneous Nontuberculous Mycobacterial Infection, 1980 to 2009: A Population-Based Study

2013 ◽  
Vol 88 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Ashley B. Wentworth ◽  
Lisa A. Drage ◽  
Nancy L. Wengenack ◽  
John W. Wilson ◽  
Christine M. Lohse
Keyword(s):  
Mycobacterial Infection ◽  
Population Based ◽  
Population Based Study ◽  
Nontuberculous Mycobacterial Infection
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