Suppression of Cell Migration and Invasion by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal microRNA-187 in Prostate Cancer

2020 ◽  
Author(s):  
Chuanyi Hu ◽  
Juan Chen ◽  
Pan You ◽  
Jie Ma ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Exosomal Microrna

scholarly journals Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling

2018 ◽  
Vol 16 (12) ◽  
pp. 1865-1878 ◽  
Author(s):  
Shreyas Lingadahalli ◽  
Sudhir Jadhao ◽  
Ying Ying Sung ◽  
Mi Chen ◽  
Lingling Hu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

MiR-375 Enriched in Bone Marrow Mesenchymal Stem Cells (BMSC) Exosomes Inhibits Prostate Cancer Cell Migration and Invasion by Down-Regulating Trefoil Factor 3 (TFF3)

2021 ◽  
Vol 11 (12) ◽  
pp. 2407-2414
Author(s):  
Qihong Liang ◽  
Wei Zhong
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cell Migration ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Clinical Samples ◽  
Cell Migration And Invasion ◽  
Marrow Mesenchymal Stem Cells ◽  
Proliferation And Metastasis

To study the effect and mechanism of miR-375 enriched in BMSC exosomes on prostate cancer (PC) cells. Bioinformatics assessed the potential regulatory miRNA of TFF3 and miR-375 level in breast cancer cells and breast cancer clinical samples was detected by PCR. Dual luciferase assay validated the relationship between TFF3 and miR-375. miR-375 mimics or sh-TFF3 was transfected into PC cells, followed by measuring miR-375 and TFF3 by PCR and Western-blot. Cell proliferation, invasion, migration and apoptosis by Edu staining, transwell and flow cytometry. The BMSC exosomes were then isolated and co-cultured with PC cells to detect cell proliferation and invasion. PC cells and tissues showed the expression of miR-375 was decreased, indicated that miR-375 specifically inhibited TFF3 level. miR-375 was enriched in MSC-derived exosomes and could be transferred to PC cells. miR-375 mimics, exosome miR-375 or silenced TFF3 inhibited TFF3 level, up-regulated PCNA, MMP-2/9 expression, thereby inhibiting cell proliferation and metastasis, and promoting cell apoptosis. miR-375 is enriched in BMSC exosomes and inhibits PC cell migration and invasion by reducing TFF3.

17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation

2020 ◽  
Vol 530 (2) ◽  
pp. 381-388 ◽  
Author(s):  
Wenbi Zhang ◽  
Xiong Li ◽  
He Li ◽  
Xiang Lu ◽  
Junling Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Migration ◽  
17Β Estradiol
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