Perinatal Arterial Ischemic Stroke in Preterm and Term Born Infants: A National Capture- Recapture Calculation Corrected Surveillance Study

2020 ◽  
Author(s):  
Anna-Lisa Sorg ◽  
Rüdiger von Kries ◽  
Mathias Klemme ◽  
Lucia Gerstl ◽  
Ursula Felderhoff-Müser ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Surveillance Study ◽  
Arterial Ischemic Stroke ◽  
Capture Recapture ◽  
Perinatal Arterial Ischemic Stroke

Incidence Estimates of Perinatal Arterial Ischemic Stroke in Preterm- and Term-Born Infants: A National Capture-Recapture Calculation Corrected Surveillance Study

Neonatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Anna-Lisa Sorg ◽  
Rüdiger von Kries ◽  
Mathias Klemme ◽  
Lucia Gerstl ◽  
Ursula Felderhoff-Müser ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Incidence Rates ◽  
Surveillance Study ◽  
Federal State ◽  
Arterial Ischemic Stroke ◽  
Term Infants ◽  
Significant Difference ◽  
Capture Recapture ◽  
Preterm Born ◽  
Perinatal Arterial Ischemic Stroke

<b><i>Introduction:</i></b> Data on valid incidence estimates of perinatal arterial ischemic stroke (PAIS) are scarce. This analysis aims to determine incidence of PAIS in term- and preterm-born infants and to investigate clinical differences related to prematurity. <b><i>Methods:</i></b> This surveillance study (2015–2017) in all German paediatric hospital estimated incidences for MRI-confirmed PAIS in term and preterm infants. To correct for under-reporting, we performed capture-recapture-calculations (CRC) in the most populous federal state and extrapolated nationwide. Differences in clinical presentation in term- and preterm-born infants were assessed. <b><i>Results:</i></b> 126 term- and 19 preterm-born infants with PAIS were reported. CRC corrected incidence of PAIS was 22 (95% confidence interval [CI] 17, 27) per 100,000 live births. Stratified by prematurity, the incidence was 32 (95% CI 15, 49) per 100,000 in preterm-born infants and 21 (95% CI 16, 26) per 100,000 term-born infants (significant difference <i>p</i> = 0.001). In symptomatic cases only (<i>n</i> = 120 term born, <i>n</i> = 12 preterm born), incidences did not differ. Risk factor patterns were similar, but number of risk factors in preterm babies was elevated (mean 3.8 vs. 2.9; <i>p</i> = 0.01) and median age at diagnosis was increased (5 vs. 3 days; <i>p</i> = 0.04). Clinical seizures were observed in 88% (106/120) of symptomatic term infants compared to 33% (4/12) in preterm-born infants (<i>p</i> &#x3c; 0.0001). <b><i>Conclusion:</i></b> PAIS incidence rates in Germany, extrapolated from estimates for completeness of reporting in the largest federal state, were within the range of other population-based studies. As a novel finding, we detected symptomatic PAIS in preterm-born infants to be as common as in term-born infants although their symptoms were often unspecific.

Neurocognitive outcome in a 6-year-old girl with a history of perinatal stroke

2011 ◽  
Vol 26 (S2) ◽  
pp. 1100-1100
Author(s):  
A. Matos-Pires ◽  
N. Cardoso-Pereira
Keyword(s):  
Working Memory ◽  
Ischemic Stroke ◽  
Verbal Learning ◽  
Arterial Ischemic Stroke ◽  
Intellectual Performance ◽  
Perinatal Stroke ◽  
Intellectual Outcome ◽  
History Of ◽  
Perinatal Arterial Ischemic Stroke

Perinatal Stroke involves an often poorly understood neurocognitive events affecting the fetus and the new born with a potential for serious intellectual outcome.Our aim is to present a case study on the issue of neurocognitive defects on domains such as intellectual performance, attention and vigilance, executive functioning, visual perception, speed of processing, verbal learning and memory, and working memory on a 6 year old girl with perinatal arterial ischemic stroke.

scholarly journals Risk of Later Seizure After Perinatal Arterial Ischemic Stroke: A Prospective Cohort Study

PEDIATRICS ◽  
2011 ◽  
Vol 127 (6) ◽  
pp. e1550-e1557 ◽  
Author(s):  
C. J. Wusthoff ◽  
S. K. Kessler ◽  
A. Vossough ◽  
R. Ichord ◽  
S. Zelonis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

scholarly journals Automatic Segmentation of Perinatal Arterial Ischemic Stroke Volume

2011 ◽  
Vol 70 ◽  
pp. 155-155
Author(s):  
N E van der Aa ◽  
I Isgum ◽  
F Groenendaal ◽  
M A Viergever ◽  
L S de Vries ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Stroke Volume ◽  
Automatic Segmentation ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

New insights (and new interrogations) in perinatal arterial ischemic stroke

2011 ◽  
Vol 127 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Stéphane Chabrier ◽  
Béatrice Husson ◽  
Mickaël Dinomais ◽  
Pierre Landrieu ◽  
Sylvie Nguyen The Tich
Keyword(s):  
Ischemic Stroke ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

Cerebral Palsy After Perinatal Arterial Ischemic Stroke

2008 ◽  
Vol 23 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Meredith R. Golomb ◽  
Bhuwan P. Garg ◽  
Chandan Saha ◽  
Faouzi Azzouz ◽  
Linda S. Williams
Keyword(s):  
Cerebral Palsy ◽  
Ischemic Stroke ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

scholarly journals Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells

2017 ◽  
Vol 83 (1-2) ◽  
pp. 372-384 ◽  
Author(s):  
Nienke Wagenaar ◽  
Caroline G M de Theije ◽  
Linda S de Vries ◽  
Floris Groenendaal ◽  
Manon J N L Benders ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ischemic Stroke ◽  
Neurotrophic Factors ◽  
Arterial Ischemic Stroke ◽  
Perinatal Arterial Ischemic Stroke

Two Children With Both Arm Ischemia and Arterial Ischemic Stroke During the Perinatal Period

2011 ◽  
Vol 26 (12) ◽  
pp. 1548-1554 ◽  
Author(s):  
Marilyn J. McKasson ◽  
Meredith R. Golomb
Keyword(s):  
Ischemic Stroke ◽  
Methylenetetrahydrofolate Reductase ◽  
Delayed Diagnosis ◽  
Limb Ischemia ◽  
Perinatal Period ◽  
Resonance Imaging ◽  
Arterial Ischemic Stroke ◽  
Cerebral Magnetic Resonance Imaging ◽  
Ischemic Limb ◽  
Perinatal Arterial Ischemic Stroke

It is rare for both limb ischemia and arterial ischemic stroke to occur in the same child during the perinatal period. Two children who appear to have had perinatal emboli to both an arm and a middle cerebral artery territory are presented here. One child required amputation of the ischemic limb below the shoulder, and the other required skin grafts to the distal ischemic fingers. Each of these children later received cerebral magnetic resonance imaging for evaluation of developmental delay and was found to have what appeared to be old perinatal arterial ischemic stroke. Both children were homozygous for the methylenetetrahydrofolate reductase C677T gene variant. Eight other children with perinatal limb ischemia and stroke were found on literature review; several also had delayed diagnosis of perinatal stroke. This report examines the approach to diagnosis and treatment in each of these and makes suggestions for the similar cases in the future.

scholarly journals Risk Factors for Perinatal Arterial Ischemic Stroke

Cell Medicine ◽  
2018 ◽  
Vol 10 ◽  
pp. 215517901878534 ◽  
Author(s):  
Daniela Munoz ◽  
María José Hidalgo ◽  
Fernanda Balut ◽  
Mónica Troncoso ◽  
Susana Lara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Cesarean Section ◽  
Apgar Score ◽  
Birth Asphyxia ◽  
Arterial Ischemic Stroke ◽  
Emergency Cesarean Section ◽  
Emergency Cesarean ◽  
Associated Risk Factors ◽  
Perinatal Arterial Ischemic Stroke

Introduction: Arterial ischemic stroke in newborns is an important cause of neonatal morbidity and mortality. Its pathophysiology and associated risk factors are not yet clearly understood and defined. Objective: The aim of this retrospective study was to investigate possible risk factors in diagnosed cases of PAIS (perinatal arterial ischemic stroke). Materials and methods: Case–control study. Clinical data of patients with PAIS diagnosis were analyzed. Two healthy controls were selected for each PAIS case, matched for gestational age. Risk factors were explored using univariable and multivariable analysis. Outcome: 40 patients were included in the study, 24 males and 16 females; 52.5% of cases were diagnosed within the first month of birth, and 47.5% were retrospectively diagnosed. The results showed a male predominance (66.7%). The distribution of cerebral ischemic injury was predominantly medial cerebral artery (87.5%) and occurred more commonly in the left cerebral hemisphere (62.5%). Significant risk factors in the univariate analysis (P < 0.05) were primiparity, stillbirth, neonatal sepsis, asphyxia, twin pregnancy, placenta abruption, emergency cesarean section, Apgar score ≤7 after 5 min, breech presentation, and hyperbilirubinemia. In the multivariate analysis, primiparity (OR 11.74; CI 3.28–42.02), emergency cesarean section (OR 13.79; CI 3.51–54.13), birth asphyxia (OR 40.55; CI 3.08–532.94) and Apgar score ≤7 after 5 min (OR 13.75; CI 1.03–364.03) were significantly associated factors with PAIS. Only five (16.6%) patients had an abnormal thrombophilia study. Conclusion: Risk factors of primiparity, emergency cesarean section, birth asphyxia, and Apgar score ≤7 after 5 min were significantly associated with perinatal stroke. More studies with a larger number of patients and with prolonged follow up are required to establish more clearly the associated risk factors involved in this pathology.

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