Reversal of Cancer Cell Invasiveness Via Reprogramming Their Golgi pH Homeostasis

2020 ◽  
Author(s):  
Elham Khosrowabadi ◽  
Antti Rivinoja ◽  
Maija Risteli ◽  
Anne Tuomisto ◽  
Tuula Salo ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Ph Homeostasis ◽  
Cell Invasiveness ◽  
Cancer Cell Invasiveness

scholarly journals P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2342 ◽  
Author(s):  
Lucie Brisson ◽  
Stéphanie Chadet ◽  
Osbaldo Lopez-Charcas ◽  
Bilel Jelassi ◽  
David Ternant ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Progression ◽  
P2x7 Receptor ◽  
Mammary Cancer ◽  
Tumour Progression ◽  
Mammary Cancer Cell ◽  
Cell Invasiveness ◽  
Cancer Cell Invasiveness

The P2X7 receptor is an ATP-gated cation channel with a still ambiguous role in cancer progression, proposed to be either pro- or anti-cancerous, depending on the cancer or cell type in the tumour. Its role in mammary cancer progression is not yet defined. Here, we show that P2X7 receptor is functional in highly aggressive mammary cancer cells, and induces a change in cell morphology with fast F-actin reorganization and formation of filopodia, and promotes cancer cell invasiveness through both 2- and 3-dimensional extracellular matrices in vitro. Furthermore, P2X7 receptor sustains Cdc42 activity and the acquisition of a mesenchymal phenotype. In an immunocompetent mouse mammary cancer model, we reveal that the expression of P2X7 receptor in cancer cells, but not in the host mice, promotes tumour growth and metastasis development, which were reduced by treatment with specific P2X7 antagonists. Our results demonstrate that P2X7 receptor drives mammary tumour progression and represents a pertinent target for mammary cancer treatment.

scholarly journals SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness

2015 ◽  
Vol 76 (3) ◽  
pp. 607-618 ◽  
Author(s):  
David Crottès ◽  
Raphael Rapetti-Mauss ◽  
Francisca Alcaraz-Perez ◽  
Mélanie Tichet ◽  
Giuseppina Gariano ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Electrical Activity ◽  
Cancer Cell ◽  
Cell Invasiveness ◽  
Cancer Cell Invasiveness

scholarly journals Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

2013 ◽  
Vol 123 (12) ◽  
pp. 5411-5411
Author(s):  
Andrea Casazza ◽  
Veronica Finisguerra ◽  
Lorena Capparuccia ◽  
Andrea Camperi ◽  
Jakub M. Swiercz ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Cell Invasiveness ◽  
Metastatic Spreading ◽  
Cancer Cell Invasiveness
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