Ocular Manifestations and Tear or Conjunctival Swab PCR Positivity for 2019-nCoV in Patients with COVID-19: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Phulen Sarma ◽  
Hardeep Kaur ◽  
Harpinder Kaur ◽  
Jaimini Bhattacharyya ◽  
Manisha Prajapat ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Ocular Manifestations ◽  
Conjunctival Swab

scholarly journals The Prevalence of ocular manifestations and ocular samples polymerase chain reaction positivity in patients with COVID 19 - a systematic review and meta-analysis

2020 ◽  
Author(s):  
Soumen Sadhu ◽  
Sushmitha Arcot Dandapani ◽  
Deepmala Mazumdar ◽  
Sangeetha Srinivasan ◽  
Jyotirmay Biswas
Keyword(s):  
Systematic Review ◽  
Polymerase Chain Reaction ◽  
Case Reports ◽  
Meta Analysis ◽  
Initial Symptom ◽  
Chain Reaction ◽  
Ocular Manifestations ◽  
Polymerase Chain Reaction Positivity ◽  
Pooled Prevalence ◽  
Polymerase Chain

AbstractObjectiveTo estimate the prevalence of ocular manifestations and ocular samples polymerase chain reaction (PCR) positivity among COVID-19 patients.MethodsA systematic literature review was performed using search engines (PubMed, Google Scholar, Medrixv and BioRixv) with keywords “SARS-CoV-2”, “novel coronavirus”, “COVID-19”, “ocular manifestations”, “conjunctival congestion”, “Ocular detection”, “Polymerase chain reaction”, and “conjunctivitis”. The measure of heterogeneity was evaluated with the I2 statistic. The pooled proportion of patients presenting with symptoms and ocular samples PCR positivity was estimated.ResultsA total of 20 studies (14 studies and 6 case-reports) were included in the systematic review and 14 studies were included in the meta-analysis. The pooled prevalence of conjunctivitis was 5.17% (95% CI: 2.90-8.04). Conjunctivitis was reported as an initial symptom of the disease in 0.858 % (95% CI: 0.31-1.67). Common associated features include itching, chemosis, epiphora. Seven patients (29 %) with conjunctivitis showed positive results in ocular samples, whereas 13 patients (54%) showed positive only in their nasopharyngeal samples (NPs) or sputum samples and 4 patients (16 %) were negative for both NPs and Sputum as well as ocular samples. The pooled prevalence of ocular PCR positivity was 2.90 % (95% CI: 1.77 – 4.46) vs. NPs 89.8% (95% CI: 78.80-79.0).ConclusionThe prevalence of conjunctivitis and ocular samples PCR positivity among COVID-19 patients was low indicating that the eye is a less affected organ. However, conjunctivitis may present as the first symptom of the disease making the patient seek medical care at the earliest.SynopsisViral conjunctivitis was the only symptom reported. The prevalence of conjunctivitis and ocular samples polymerase chain reaction positivity among COVID-19 patients was low indicating the eye is a less effected organ.

scholarly journals Current Evidence of 2019 Novel Coronavirus Disease (COVID-19) Ocular Transmission: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Kai Cao ◽  
Brad Kline ◽  
Ying Han ◽  
Gui-shuang Ying ◽  
Ning Li Wang
Keyword(s):  
Systematic Review ◽  
Prevalence Rate ◽  
Meta Analysis ◽  
Current Evidence ◽  
Prevalence Rates ◽  
Ocular Symptoms ◽  
Pooled Prevalence ◽  
Conjunctival Swab ◽  
Positive Rate ◽  
Novel Coronavirus

Objective. To estimate the prevalence rate of ocular symptoms and the positive rate of conjunctival swab samples of patients diagnosed with 2019 Novel Coronavirus Disease (COVID-19). Methods. We performed a systematic review and meta-analysis. A comprehensive literature search was done based on PubMed, Embase, MedRxiv, and the Cochrane Library. The primary outcomes are the prevalence rate of conjunctivitis/conjunctival congestion and the positive rate of conjunctival swab samples. Rates were expressed as proportions with 95% confidence intervals (CIs). Results. A total of 12 studies with 1930 participants were included for meta-analysis. The pooled prevalence rate of conjunctivitis/conjunctival congestion was 8% (95% CI: 5%-12%). 1% (95% CI: 1%-4%) of COVID-19 patients were diagnosed with conjunctivitis/conjunctival congestion as the initial symptom. The pooled positive rate of conjunctival swab samples was 3% (95% CI: 2%-5%). We also assessed other ocular symptoms reported in the 12 studies, including foreign body sensation, increased secretion, and eye itching. The pooled prevalence rates were 6% (95% CI: 3%-10%), 10% (95% CI: 8%-12%), and 9% (95% CI: 7%-10%), respectively. Conclusions. The evidence on the positive rate of conjunctival swab samples and the prevalence rates of ocular symptoms indicated that COVID-19 ocular transmission was possible but less likely.

scholarly journals COVID-19 and conjunctivitis: a meta-analysis

2021 ◽  
Vol 13 ◽  
pp. 251584142110033
Author(s):  
Mashael Al-Namaeh
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Odds Ratio ◽  
Literature Search ◽  
Pediatric Patients ◽  
Meta Analysis ◽  
Review Article ◽  
Wuhan City ◽  
Ocular Manifestations ◽  
Adults And Children

COVID-19 is a disease first identified in Wuhan City, Hubei Province, China, in December 2019, causes by a SARS-COV-2 virus infection. By 27 October 2020, 43,921,473 confirmed cases were reported worldwide, with 1,166,389 COVID-19 deaths. Conjunctivitis has been reported in adults and pediatric patients with COVID-19. Objective: The aim of this meta-analysis is to estimate the odd Ratio (ORs) of conjunctivitis in patients with COVID-19. Methods: A systematic review and meta-analysis have been performed using the PubMed and Google Scholar literature search. The ORs of conjunctivitis in adults and pediatric patients is the outcome of this meta-analysis. Results: There have been 1041 articles published since the outbreak in December 2019, according to the latest literature. For the meta-analysis, 20 studies with a total of 3383 participants were included. The odds ratio (ORs) of conjunctivitis was 0.01 (95% confidence interval [CI]: 0.00–0.02). No bias has been reported. Conclusion: Conjunctivitis is the most common ocular manifestations reported in adults. This comprehensive meta-analysis quantifies the existing evidence linking conjunctivitis with COVID-19 and highlights the high percentage of heterogeneity that is shown in the current studies. Finally, it offers a single review article which includes all the current articles available for COVID-19 and conjunctivitis in adults and children.

scholarly journals Ocular Manifestations of COVID-19: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Naser Nasiri ◽  
Hamid Sharifi ◽  
Azam Bazrafshan ◽  
Atefeh Noori ◽  
Mohammad Karamouzian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cross Sectional ◽  
Ocular Manifestations ◽  
Ocular Symptoms ◽  
Body Sensation ◽  
Pooled Prevalence ◽  
Using Data ◽  
Meta Analyses

Several studies have reported the characteristics of Coronavirus disease 2019 (COVID-19), yet there is a gap in our understanding of the ocular manifestations of COVID-19. In this systematic review and meta-analysis, we investigated the prevalence of ocular manifestations in COVID-19 patients. We searched Pubmed, Embase, Scopus, Web of Science, and medRxiv from December 1, 2019 to August 11, 2020. Two independent reviewers screened the articles, abstracted the data, and assessed the quality of included studies in duplicate. Thirty-eight studies were eligible after screening of 895 unique articles, with a total of 8,219 COVID-19 patients (55.3% female; n = 3,486 out of 6,308 patients). Using data extracted from cross-sectional studies, we performed randomeffects meta-analyses to estimate the pooled prevalence of ocular symptoms along with 95% confidence interval (CI). The prevalence of ocular manifestations was estimated to be 11.03% (95% CI: 5.71–17.72). In the studies that reported the details of observed ocular symptoms, the most common ocular manifestations were dry eye or foreign body sensation (n = 138, 16%), redness (n = 114, 13.3%), tearing (n = 111, 12.8%), itching (n = 109, 12.6%), eye pain (n = 83, 9.6%) and discharge (n = 76, 8.8%). Moreover, conjunctivitis had the highest rate among reported ocular diseases in COVID-19 patients (79 out of 89, 88.8%). The results suggest that approximately one out of ten COVID-19 patients show at least one ocular symptom. Attention to ocular manifestations, especially conjunctivitis, can increase the sensitivity of COVID-19 detection among patients.

scholarly journals Ocular Manifestations of Paediatric Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

2018 ◽  
Vol 12 (7) ◽  
pp. 870-879 ◽  
Author(s):  
Giorgio Ottaviano ◽  
Silvia Salvatore ◽  
Alessandro Salvatoni ◽  
Stefano Martelossi ◽  
Alessandro Ventura ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Ocular Manifestations ◽  
Inflammatory Bowel

scholarly journals Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis

2021 ◽  
pp. 102191
Author(s):  
Yueyang Zhong ◽  
Kai Wang ◽  
Yanan Zhu ◽  
Danni Lyu ◽  
Yinhui Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Ocular Manifestations

scholarly journals Ocular involvment of coronavirus disease (COVID-19): A systematic review of conjunctival swab results

2020 ◽  
Vol 3 (2) ◽  
pp. 118
Author(s):  
Indra Tri Mahayana ◽  
Natalia Christina Angsana ◽  
Muhammad Zhafran Ayyasy ◽  
Anastasya Sondang Hutajulu ◽  
Suhardjo Suhardjo
Keyword(s):  
Systematic Review ◽  
Ocular Surface ◽  
Scientific Literature ◽  
Inclusion Criteria ◽  
Chain Reaction ◽  
Research Papers ◽  
Ocular Manifestations ◽  
Pubmed Database ◽  
Conjunctival Swab ◽  
Polymerase Chain

Coronavirus disease (COVID-19) is a pandemic disease which is caused by the latest discovered coronavirus. Conjunctivitis is allegedly the first presentation of COVID-19 since it can spread by aerosol contact with the conjunctiva. The present study aimed to systematically review the employment of conjunctival swab with Real-time Polymerase Chain Reaction in detecting SARS-Cov-2. The research is a systematic review of the published scientific literature on findings of conjunctival swab of COVID-19 from PUBMED database and other additional sources (i.e: Google Scholar). The search method was done using “COVID-19 OR coronavirus OR SARS-COV2, AND conjunctivitis, AND ocular manifestations, AND conjunctival swab” as keywords. Inclusion criteria were any papers that related to the entered keywords and have conjunctival swab as a reported outcome. Letters, reviews, and editorials describing other studies reporting COVID-19 and conjunctival swab were excluded. Only four research papers were found and included in the literature review. From the four current research papers, positive SARS-CoV-2 results were yielded from 0-5.26% of conjunctival swab specimens. In conclusion, although the presence of the SARS-CoV-2 virus on the ocular surface remains unclear, the prevention of infection transmission through an ocular surface is mandatory by wearing goggles (or shield), mask (N-95 recommended) and gown.

scholarly journals Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Denis Sereno ◽  
Mohammad Akhoundi ◽  
Kourosh Sayehmri ◽  
Asad Mizraei ◽  
Philippe Holzmuller ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Genetic Material ◽  
Body Fluids ◽  
Unicellular Eukaryotes ◽  
Animal Pathogens ◽  
Conjunctival Swab ◽  
Material Detection ◽  
Animal Trypanosomiasis ◽  
Body Secretion

Unicellular eukaryotes of the Trypanosomatidae family include human and animal pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the diseases they caused requires the sampling of body fluids (blood, lymph, peritoneal fluid, cerebrospinal fluid, etc.) or organ biopsies (bone marrow, spleen, etc.), which are mostly obtained through invasive methods. Body fluids or appendages can be alternatives to these invasive biopsies but appropriateness remains poorly studied. To further address this question, we perform a systematic review on clues evidencing the presence of parasites, genetic material, antibodies, and antigens in body secretions, appendages, or the organs or proximal tissues that produce these materials. Paper selection was based on searches in PubMed, Web of Science, WorldWideScience, SciELO, Embase, Google. The information of each selected article (n=333) was classified into different sections and data were extracted from 77 papers. The presence of Trypanosomatidae parasites has been tracked in most of organs or proximal tissues that produce body secretions or appendages, in naturally or experimentally infected hosts. The meta-analysis highlights the paucity of studies on Human African Trypanosomiasis and a the absence on animal Trypanosomiasis. Among the collected data high heterogeneity in terms of the I2 statistic (100%) is recorded. A high positivity is recorded for antibody and genetic material detection in urine of patients and dogs suffering leishmaniasis, and of antigen for leishmaniasis and Chagas disease. Data on conjunctival swab can be analyzed with molecular methods solely for dogs suffering canine visceral leishmaniasis. Saliva and hair/bristle showed a pretty good positivity that support their potential to be used for leishmaniasis diagnosis. In conclusion, our study pinpoints significant gaps that need to be filled in order to properly address the interest of body secretion and hair or bristle for the diagnosis of infections caused by Leishmania and by other Trypanosomatidae parasites.

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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