Latitude Dependence of the COVID-19 Mortality Rate—A Possible Relationship to Vitamin D Deficiency?

2020 ◽  
Author(s):  
Mark Braiman
Keyword(s):  
Vitamin D ◽  
Mortality Rate ◽  
Vitamin D Deficiency ◽  
Latitude Dependence

scholarly journals Delta-Procalcitonin and Vitamin D Can Predict Mortality of Internal Medicine Patients with Microbiological Identified Sepsis

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 331
Author(s):  
Alberto Tosoni ◽  
Anthony Cossari ◽  
Mattia Paratore ◽  
Michele Impagnatiello ◽  
Giovanna Passaro ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Vitamin D ◽  
Mortality Rate ◽  
Prospective Study ◽  
Vitamin D Deficiency ◽  
Severe Vitamin ◽  
Prognostic Accuracy ◽  
Vitamin D Levels ◽  
Internal Medicine Wards ◽  
Previous Prospective Study

Background: The management of septic patients hospitalized in Internal Medicine wards represents a challenge due to their complexity and heterogeneity, and a high mortality rate. Among the available prognostic tools, procalcitonin (PCT) is considered a marker of bacterial infection. Furthermore, an association between vitamin D deficiency and poor sepsis-related outcomes has been described. Objectives: To evaluate the prognostic accuracy of two consecutive PCT determinations (Delta-PCT) and of vitamin D levels in predicting mortality in a population of patients with microbiological identified sepsis admitted to Internal Medicine wards. Methods: This is a sub-analysis of a previous prospective study. A total of 80 patients had at least two available consecutive PCT determinations, while 63 had also vitamin D. Delta-PCT was defined as a reduction of PCT > 50% after 48 h, >75% after 72 h, and >85% after 96 h. Mortality rate at 28- and 90-days were considered as main outcome. Results: Mortality rate was 18.7% at 28-days and 30.0% at 90-days. Baseline PCT levels did not differ between survived and deceased patients (28-days: p = 0.525; 90-days: p = 0.088). A significantly higher proportion of survived patients showed Delta-PCT (28-days: p = 0.002; 90-days: p < 0.001). Delta-PCT was associated with a lower 28-days (p = 0.007; OR = 0.12, 95%CI 0.02–0.46) and 90-days mortality (p = 0.001; OR = 0.17, 95%CI 0.06–0.48). A significantly higher proportion of deceased patients showed severe vitamin D deficiency (28-days: p = 0.047; 90-days: p = 0.049). Severe vitamin D deficiency was associated with a higher 28-days (p = 0.058; OR = 3.95, 95%CI 1.04–19.43) and 90-days mortality (p = 0.054; OR = 2.94, 95%CI 1.00–9.23). Conclusions: Delta-PCT and vitamin D represent two useful tests for predicting prognosis of septic patients admitted to Internal Medicine wards.

scholarly journals Is vitamin D deficiency associated with the COVID-19 epidemic in Europe?

2021 ◽  
Author(s):  
Dimitra Rafailia Bakaloudi ◽  
Michail Chourdakis
Keyword(s):  
Vitamin D ◽  
Mortality Rate ◽  
Vitamin D Deficiency ◽  
Case Series ◽  
Correlation Coefficients ◽  
Middle Latitude ◽  
European Countries ◽  
Global Pandemic ◽  
Review Study ◽  
Positive Correlations

AbstractObjectiveCOVID-19 has emerged as a global pandemic, affecting nearly 80 million people from 218 countries as of December 2020. At the same time, vitamin D deficiency seems to be prevalent among COVID-19 patients. Hence, the association between the prevalence of vitamin D deficiency and COVID-19 infection and mortality among European countries was examined.DesignA case series and recent literature review studySettingsInformation on prevalence of vitamin D deficiency in each country was retrieved through literature searching on PubMed® database. As of December, 23rd 2020, COVID-19 infections and mortalities per million population were extracted from the Worldometer website, whereas the latitude of each country was taken from the CSGNetwork website. The association between both vitamin D deficiency and COVID-19 infection and mortality were explored using correlation coefficients and scatterplots.ParticipantsEuropean Countries-PopulationsResultsThe range of prevalence of vitamin D deficiency among European countries was 6.9-75.1%, with most countries facing more than 50% of vitamin D deficiency among their population. Significant positive correlations were observed between COVID-19 infections (r=0.82; p<0.001) and mortalities (r=0.53; p=0.05) per million population with the prevalence of vitamin D deficiency. Most of the high latitude countries showed lower rates of COVID-19 infections and mortalities compared to middle latitude countries.ConclusionPrevalence of vitamin D deficiency was significantly associated with both infection and mortality rate of COVID-19 among European countries. Thus, it is an important parameter to be considered when implementing preventive measures to mitigate the mortality rate of COVID-19.

Vitamin D Deficiency

2011 ◽  
Vol 44 (14) ◽  
pp. 22
Author(s):  
WILLIAM E. GOLDEN ◽  
ROBERT H. HOPKINS
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency

Abstract #1236: The Blood Turnover Markers and Parathormon Levels in Menopausal Women with Vitamin D Deficiency

2015 ◽  
Vol 21 ◽  
pp. 293-294
Author(s):  
Mara Carsote ◽  
Cristina Capatina ◽  
Alexandra Mihai ◽  
Andreea Geleriu ◽  
Rodica Petris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Menopausal Women ◽  
Turnover Markers
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