Spatial Dependence and Space-Time Trends in Extreme Events

2020 ◽  
Author(s):  
John H. J. Einmahl ◽  
Ana Ferreira ◽  
Laurens de Haan ◽  
Claudia Neves ◽  
Chen Zhou
Keyword(s):  
Extreme Events ◽  
Spatial Dependence ◽  
Time Trends ◽  
Space Time

scholarly journals Space-time trends in U.S. meteorological droughts

2016 ◽  
Vol 8 ◽  
pp. 235-259 ◽  
Author(s):  
Poulomi Ganguli ◽  
Auroop R. Ganguly
Keyword(s):  
Time Trends ◽  
Space Time ◽  
Meteorological Droughts

Bayesian Extrapolation of Space-Time Trends in Cancer Registry Data

Biometrics ◽  
2004 ◽  
Vol 60 (4) ◽  
pp. 1034-1042 ◽  
Author(s):  
Volker Schmid ◽  
Leonhard Held
Keyword(s):  
Cancer Registry ◽  
Time Trends ◽  
Space Time ◽  
Registry Data ◽  
Cancer Registry Data

scholarly journals Space-Time Trends in Lassa Fever in Sierra Leone by ELISA Serostatus, 2012–2019

2021 ◽  
Vol 9 (3) ◽  
pp. 586
Author(s):  
Jeffrey Shaffer ◽  
John Schieffelin ◽  
Mambu Momoh ◽  
Augustine Goba ◽  
Lansana Kanneh ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Time Trends ◽  
Severe Disease ◽  
Case Fatality ◽  
Lassa Fever ◽  
Space Time ◽  
Dry Season ◽  
Sub Saharan Africa ◽  
Hemorrhagic Disease ◽  
Illness Onset

Lassa fever (LF) is a viral hemorrhagic disease found in Sub-Saharan Africa and is responsible for up to 300,000 cases and 5000 deaths annually. LF is highly endemic in Sierra Leone, particularly in its Eastern Province. Kenema Government Hospital (KGH) maintains one of only a few LF isolation facilities in the world with year-round diagnostic testing. Here we focus on space-time trends for LF occurring in Sierra Leone between 2012 and 2019 to provide a current account of LF in the wake of the 2014–2016 Ebola epidemic. Data were analyzed for 3277 suspected LF cases and classified as acute, recent, and non-LF or prior LF exposure using enzyme-linked immunosorbent assays (ELISAs). Presentation rates for acute, recent, and non-LF or prior LF exposure were 6.0% (195/3277), 25.6% (838/3277), and 68.4% (2244/3277), respectively. Among 2051 non-LF or prior LF exposures, 33.2% (682/2051) tested positive for convalescent LF exposure. The overall LF case-fatality rate (CFR) was 78.5% (106/135). Both clinical presentations and confirmed LF cases declined following the Ebola epidemic. These declines coincided with an increased duration between illness onset and clinical presentation, perhaps suggesting more severe disease or presentation at later stages of illness. Acute LF cases and their corresponding CFRs peaked during the dry season (November to April). Subjects with recent (but not acute) LF exposure were more likely to present during the rainy season (May to October) than the dry season (p < 0.001). The findings here suggest that LF remains endemic in Sierra Leone and that caseloads are likely to resume at levels observed prior to the Ebola epidemic. The results provide insight on the current epidemiological profile of LF in Sierra Leone to facilitate LF vaccine studies and accentuate the need for LF cohort studies and continued advancements in LF diagnostics.

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