Antibiotic Use and Breast Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis

2020 ◽  
Author(s):  
Johanna Simin ◽  
Rulla M. Tamimi ◽  
Lars Engstrand ◽  
Steven Callens ◽  
Nele Brusselaers
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Antibiotic Use

scholarly journals Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies

2015 ◽  
Vol 114 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Mathilde Touvier ◽  
Philippine Fassier ◽  
Mathilde His ◽  
Teresa Norat ◽  
Doris S. M. Chan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dose Response ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Hdl Cholesterol ◽  
Inverse Association

The objective of the present study was to conduct the first systematic review and meta-analysis of prospective studies investigating the associations between total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels and the risk of breast cancer. Relevant studies were identified in PubMed (up to January 2014). Inclusion criteria were original peer-reviewed publications with a prospective design. Random-effects models were used to estimate summary hazard ratios (HR) and 95 % CI. Distinction was made between studies that did or did not exclude cancer cases diagnosed during the first years of follow-up, thereby eliminating potential preclinical bias. Overall, the summary HR for the association between TC and breast cancer risk was 0·97 (95 % CI 0·94, 1·00; dose–response per 1 mmol/l increment, thirteen studies), and that between HDL-C and breast cancer risk was 0·86 (95 % CI 0·69, 1·09; dose–response per 1 mmol/l increment, six studies), with high heterogeneity (I2= 67 and 47 %, respectively). For studies that eliminated preclinical bias, an inverse association was observed between the risk of breast cancer and TC (dose–response HR 0·94 (95 % CI 0·89, 0·99), seven studies, I2= 78 %; highest v. lowest HR 0·82 (95 % CI 0·66, 1·02), nine studies, I2= 81 %) and HDL-C (dose–response HR 0·81 (95 % CI 0·65, 1·02), five studies, I2= 30 %; highest v. lowest HR 0·82 (95 % CI 0·69, 0·98), five studies, I2= 0 %). There was no association observed between LDL-C and the risk of breast cancer (four studies). The present meta-analysis confirms the evidence of a modest but statistically significant inverse association between TC and more specifically HDL-C and the risk of breast cancer, supported by mechanistic plausibility from experimental studies. Further large prospective studies that adequately control for preclinical bias are needed to confirm the results on the role of cholesterol level and its fractions in the aetiology of breast cancer.

scholarly journals Carbohydrates, glycemic index, glycemic load, and breast cancer risk: a systematic review and dose–response meta-analysis of prospective studies

2017 ◽  
Vol 75 (6) ◽  
pp. 420-441 ◽  
Author(s):  
Sabrina Schlesinger ◽  
Doris S.M. Chan ◽  
Snieguole Vingeliene ◽  
Ana R. Vieira ◽  
Leila Abar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dose Response ◽  
Glycemic Index ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Glycemic Load

scholarly journals Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Heleen K Bronsveld ◽  
Bas ter Braak ◽  
Øystein Karlstad ◽  
Peter Vestergaard ◽  
Jakob Starup-Linde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Insulin Analogues

Thiazolidinedione therapy and breast cancer risk in diabetic women: A systematic review and meta-analysis

2017 ◽  
Vol 34 (2) ◽  
pp. e2961 ◽  
Author(s):  
Rui Du ◽  
Lin Lin ◽  
Di Cheng ◽  
Yu Xu ◽  
Min Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis

scholarly journals Bisphosphonates and primary breast cancer risk: an updated systematic review and meta-analysis involving 963,995 women

2019 ◽  
Vol Volume 11 ◽  
pp. 593-603 ◽  
Author(s):  
Yupeng Liu ◽  
Xiaosan Zhang ◽  
Hongru Sun ◽  
Shu Zhao ◽  
Yuxue Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Primary Breast Cancer ◽  
Meta Analysis
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