Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification

2020 ◽  
Author(s):  
Jingyao Qiu ◽  
Sofia Nordling ◽  
Hema Vasavada ◽  
Eugene Butcher ◽  
Karen K. Hirschi
Keyword(s):  
Cell Cycle ◽  
Retinoic Acid ◽  
Endothelial Cell ◽  
Cell Specification

scholarly journals Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification

Cell Reports ◽  
2020 ◽  
Vol 33 (9) ◽  
pp. 108465
Author(s):  
Jingyao Qiu ◽  
Sofia Nordling ◽  
Hema H. Vasavada ◽  
Eugene C. Butcher ◽  
Karen K. Hirschi
Keyword(s):  
Cell Cycle ◽  
Retinoic Acid ◽  
Endothelial Cell ◽  
Cell Specification

scholarly journals Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

2013 ◽  
Vol 27 (5) ◽  
pp. 504-515 ◽  
Author(s):  
Kathrina L. Marcelo ◽  
Tiffany M. Sills ◽  
Suleyman Coskun ◽  
Hema Vasavada ◽  
Supriya Sanglikar ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endothelial Cell ◽  
Notch Signaling ◽  
Cell Cycle Control ◽  
Cell Specification

Cell cycle analysis during retinoic acid induced differentiation of a human embryonal carcinoma-derived cell line

1987 ◽  
Vol 20 (2-3) ◽  
pp. 153-160 ◽  
Author(s):  
Christine L. Mummery ◽  
Marga A. van Rooijen ◽  
Stieneke E. van den Brink ◽  
Siegfried W. de Laat
Keyword(s):  
Cell Cycle ◽  
Retinoic Acid ◽  
Cell Line ◽  
Embryonal Carcinoma ◽  
Cell Cycle Analysis ◽  
Induced Differentiation

scholarly journals Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein

2011 ◽  
Vol 1813 (1) ◽  
pp. 201-212 ◽  
Author(s):  
Shannon A. Baxter ◽  
David Y. Cheung ◽  
Patricia Bocangel ◽  
Hae K. Kim ◽  
Krista Herbert ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Homeodomain Protein

Retinoic acid modulates the cell-cycle in fetal rat hepatocytes and HepG2 cells by regulating cyclin-cdk activities

2003 ◽  
Vol 23 (3) ◽  
pp. 179-186 ◽  
Author(s):  
A. Alisi ◽  
Silvia Leoni ◽  
A. Piacentani ◽  
L. Conti Devirgiliis
Keyword(s):  
Cell Cycle ◽  
Retinoic Acid ◽  
Hepg2 Cells ◽  
Rat Hepatocytes ◽  
Fetal Rat

Expression of the LIM class homeobox gene Xlim-1 in pronephros and CNS cell lineages of Xenopus embryos is affected by retinoic acid and exogastrulation

Development ◽  
1994 ◽  
Vol 120 (6) ◽  
pp. 1525-1536 ◽  
Author(s):  
M. Taira ◽  
H. Otani ◽  
M. Jamrich ◽  
I.B. Dawid
Keyword(s):  
Retinoic Acid ◽  
Organizer Region ◽  
Homeobox Gene ◽  
Second Phase ◽  
Cell Specification ◽  
Spemann Organizer ◽  
Xenopus Embryos ◽  
Prechordal Mesoderm ◽  
The Central Nervous System ◽  
Lateral Mesoderm

The LIM class homeobox gene Xlim-1 is expressed in Xenopus embryos in the lineages leading to (i) the notochord, (ii) the pronephros, and (iii) certain cells of the central nervous system (CNS). In its first expression phase, Xlim-1 mRNA arises in the Spemann organizer region, accumulates in prechordal mesoderm and notochord during gastrulation, and decays in these tissues during neurula stages except that it persists in the posterior tip of the notochord. In the second phase, expression in lateral mesoderm begins at late gastrula, and converges to the pronephros at tailbud stages. Expression in a central location of the neural plate also initiates at late gastrula, expands anteriorly and posteriorly, and becomes established in the lateral regions of the spinal cord and hindbrain at tailbud stages. Thus Xlim-1 expression precedes morphogenesis, suggesting that it may be involved in cell specification in these lineages. Enhancement of Xlim-1 expression by retinoic acid (RA) was first detectable in the dorsal mesoderm at initial gastrula. During gastrulation and early neurulation, RA strongly enhanced Xlim-1 expression in all three lineages and also expanded its expressing domains; this overexpression correlated well with RA phenotypes such as enlarged pronephros and hindbrain-like structure. Exogastrulation reduced Xlim-1 expression in the lateral mesoderm and ectoderm but not in the notochord, suggesting that the second phase of Xlim-1 expression requires mesoderm/ectoderm interactions. RA treatment of exogastrulae did not revert this reduction.

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