Restricted TcR β chain CDR3 Clonotype Is Associated with Resolved Acute Hepatitis B (AHB) patients with HBsAb

2020 ◽  
Author(s):  
Dangsheng Xiao ◽  
Ju Wang ◽  
Zhitao Chen ◽  
Yirui Xie ◽  
Dong Yan ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
Acute Hepatitis B ◽  
Β Chain

scholarly journals Restricted TcR β chain CDR3 clonotype is associated with resolved acute hepatitis B subjects

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dangsheng Xiao ◽  
Ju Wang ◽  
Zhitao Chen ◽  
Xiuyuan Jin ◽  
Yirui Xie ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
High Throughput Sequencing ◽  
Mononuclear Cells ◽  
Hepatitis B Surface Antigen ◽  
Peripheral Blood Mononuclear ◽  
Two Samples ◽  
Significant Difference ◽  
Acute Hepatitis B ◽  
Β Chain

Abstract Background T cells play an important role in the prognosis of hepatitis B virus (HBV) infection, and are involved in the seroconversion of a patient from HBsAb negative to positive. To compare the T-cell receptor β-chain variable region (TcRBV) complementarity-determining region 3 (CDR3) in subjects with or without hepatitis B surface antigen (HBsAg) convert to hepatitis B surface antibody (HBsAb), the TcRBV was determined using high throughput sequencing (HTS). Methods The clonotype and diversity of CDR3 in peripheral blood mononuclear cells of subjects with resolved acute hepatitis B (AHB, HBsAb+, HBsAg-) (n = 5), chronic hepatitis B (CHB, HBsAb-, HBsAg+) (n = 5), and healthy controls (HC, HBsAb-, HBsAg-) (n = 3) were determined and analyzed using HTS (MiSeq). Results The overlapping rate of CDR3 clones of any two samples in AHB group was 2.00% (1.74% ~ 2.30%), CHB group was 1.77% (1.43% ~ 2.61%), and HC group was 1.82% (1.62% ~ 2.12%), and there was no significant difference among the three groups by Kruskal-Wallis H test. However, among the top 10 cumulative frequencies of clonotypes, only the frequency of clonotype (TcRBV20–1/BD1/BJ1–2) in AHB group was lower than that of HC group (P < 0.001). Moreover, exclude the 10 top clonotypes, there are 57 markedly different frequency of clones between AHB and CHB groups (18 clones up, 39 clones down), 179 (180–1) different clones between AHB and HC groups, and 134 different clones between CHB and HC groups. With regard to BV and BJ genotypes, there was no significant different frequency among the groups. Furthermore, there was no significant difference in the diversity of TcRBV CDR3 among the three groups (P > 0.05). Conclusions Thus, there are 57 TcRBV clonotypes that may be related to HBsAg seroconversion of AHB subjects, but the diversity of TcRBV CDR3 is not significantly related to the HBsAb positive status.

Hepatifis B virus kinetics in acute hepatitis B-A comparison between lamivudine-treated and -untreated case

2001 ◽  
Vol 120 (5) ◽  
pp. A385-A385
Author(s):  
K MICHITAKA ◽  
K KAWAI ◽  
H MATSUBARA ◽  
S NAKANISHI ◽  
N HORIIKE ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
Untreated Case ◽  
B Virus ◽  
Acute Hepatitis B

Historical study of acute hepatitis B in subjects with or without hepatitis C infection

2012 ◽  
Vol 23 (6) ◽  
pp. e146-e149 ◽  
Author(s):  
Tommaso Stroffolini ◽  
Maria Rapicetta ◽  
Flavia Lombardo ◽  
Paola Chionne ◽  
Elisabetta Madonna ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Historical Study ◽  
Hepatitis C Infection ◽  
Acute Hepatitis B

Acute Hepatitis B in Western Sweden - Genotypes and Transmission Routes

Infection ◽  
2000 ◽  
Vol 28 (3) ◽  
pp. 161-163 ◽  
Author(s):  
M. Lindh ◽  
P. Horal ◽  
G. Norkrans
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
Acute Hepatitis B

Acute hepatitis B in households of chronic carriers

Vaccine ◽  
1994 ◽  
Vol 12 (12) ◽  
pp. 1150 ◽  
Author(s):  
Laura Cialdea ◽  
Alfonso Mele ◽  
Tommaso Stroffolini ◽  
Francesca Novaco ◽  
Claudio Galanti ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
Acute Hepatitis B

Sequential occurrence of acute hepatitis B among members of a high school Sumo wrestling club

2013 ◽  
Vol 44 (10) ◽  
pp. E267-E272 ◽  
Author(s):  
Sung Kwan Bae ◽  
Hiroshi Yatsuhashi ◽  
Ikuko Takahara ◽  
Yoko Tamada ◽  
Satoru Hashimoto ◽  
...  
Keyword(s):  
High School ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Acute Hepatitis B
Sign in / Sign up

Export Citation Format

Share Document