Clinical Efficacy of Arbidol in Patients with 2019 Novel Coronavirus-Infected Pneumonia: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Kaijin Xu ◽  
Yanfei Chen ◽  
Jing Yuan ◽  
Ping Yi ◽  
Cheng Ding ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Efficacy ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Novel Coronavirus

scholarly journals Pulmonary function of patients with 2019 novel coronavirus induced-pneumonia: a retrospective cohort study

2020 ◽  
Vol 9 (5) ◽  
pp. 3447-3452 ◽  
Author(s):  
Dongqing Lv ◽  
Xi Chen ◽  
Xiaodan Wang ◽  
Linghong Mao ◽  
Jiao Sun ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pulmonary Function ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Novel Coronavirus

scholarly journals Impact of the COVID-19 epidemic on the routine emergency services in a tertiary hospital, China: a retrospective cohort study

2021 ◽  
pp. 1-18
Author(s):  
Lianjing Liang ◽  
Zhuo Zhang ◽  
Ping Li ◽  
Shanshan Weng ◽  
Hu Nie
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Emergency Services ◽  
Patient Flow ◽  
Tertiary Hospital ◽  
Chi Square ◽  
The Government ◽  
Novel Coronavirus ◽  
The Impact

Abstract Background: The sudden outbreak of COVID-19 pandemic has caused tremendous challenges to the medical system. The government and hospitals have taken robust measures to curb the spread of the deadly virus. Its impact on routine medical services is gradually being taken seriously. Objective: To identify the impact of the novel coronavirus pandemic on emergency department (ED) patient flow and the performance of the routine ED service. Methods: This retrospective cohort study was undertaken in a tertiary public teaching hospital ED in Chengdu, China. ED data of patients were routinely collected to compare demographic, clinical characteristics, and outcomes during an 8-week period from January 1st to February 25th in 2019 and 2020. Data were analyzed with the Chi-square statistical test. Results: Over the study periods, there were 31,855 and 25,244 patients presented to the ED in 2019 and 2020 respectively. During the pandemic period in 2020, the daily number of average ED visits was lower than that in 2019 (430±134.9v.s. 572±38.6, p=0.00), with fewer triage 1&2 cases (145±33.3 v.s.178±15.0, p=0.00). Nevertheless, the mortality increased remarkably during the pandemic period in 2020 (0.2% vs. 0.1%, p=0.009), with higher APACHE II scores (28 vs.19, p= 0.022) and shorter ED elapsed time (0.2 vs. 1.4 days, p=0.016) among these death cases. Conclusions: The COVID-19 pandemic had an evident impact on the patient’s behavioral patterns and routine emergency services, which caused higher ED mortality.

scholarly journals Efficacy analysis of Arbidol treatment in patients with 2019 novel coronavirus pneumonia: a retrospective cohort study

2021 ◽  
Vol 0 (0) ◽  
pp. 10626-10632
Author(s):  
Nanjin Chen ◽  
Xiaodan Wang ◽  
Sheng Zhang ◽  
Ronghai Lin ◽  
Yongpo Jiang
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Efficacy Analysis ◽  
Novel Coronavirus

scholarly journals Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Pregnancy In China: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Ming-Zhu Yin ◽  
Li-juan Zhang ◽  
Guang-Tong Deng ◽  
Chao-Fei Han ◽  
Min-Xue Shen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Clinical Symptoms ◽  
Prognostic Index ◽  
Anal Swab ◽  
Novel Coronavirus

SummaryBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the cause of the ongoing worldwide epidemic of Coronavirus Disease 2019 (COVID-19) in China and worldwide. However, there were few studies about the effects of SARS-CoV-2 infection on pregnant women.MethodsIn this retrospective cohort study, we enrolled 31 pregnant women and 35 non-pregnant women from Jan 28 to Feb 28, 2020 to evaluate the effects of SARS-CoV-2 infection during pregnancy. Inflammatory indices were used to assess the severity of COVID-19. Evidence of vertical transmission was determined by laboratory confirmation of SARS-CoV-2 in amniotic fluid, placenta, neonatal throat and anal swab and breastmilk samples.FindingsCompared with non-pregnant women, pregnant women had a significantly lower proportion of fever (54·8% vs. 87·5%, p= 0.006), a shorter average interval from onset to hospitalization (7·80 ±7·0d vs. 13·2 ± 8·2d, p= 0.005), and a higher proportion of severe or critical COVID-19 (32·3% vs. 11·4%, p=0.039). Neutrophil-to-lymphocyte ratio (NLR) and systematic immune-inflammation-based prognostic index (SII) were significantly higher on admission in severe/critical pneumonia group than moderate pneumonia group. We could not detect the presence of SARS-CoV-2 by RT-PCR in amniotic fluid, placenta, neonatal throat and anal swab and breastmilk samples.InterpretationThe clinical symptoms of COVID-19 in pregnant women were insidious and atypical, compared with those in non-pregnant patients. SII and NLR could be a useful marker to evaluate the severity of COVID-19. There was no evidence of vertical transmission during pregnancy with SARS-CoV-2 infection.FundingNational Natural Science Foundation of China and Research Funds for the Central Universities.Research in contextEvidence before this studyWe searched PubMed, Embase and Web of science for articles published up to March 1st, 2020, using the keywords (“novel coronavirus” OR “2019 novel coronavirus” OR “2019-nCoV” OR COVID-19 OR SARS-CoV-2) AND (pregnancy OR “maternal infection” OR “fetal infection”) AND “Cohort studies”.We identified no published cohort studies on pregnant women with the 2019 novel coronavirus disease (COVID-19) infection.Added value of this studyFor this retrospective cohort study, we reviewed clinical records, laboratory findings, and chest CT scans from 31 pregnant women and 35 non-pregnant women from Jan 28 to Feb 28, 2020 to evaluate the effects of SARS-CoV-2 infection during pregnancy. Inflammatory indices were used to assess the severity of COVID-19. Evidence of vertical transmission was determined by laboratory confirmation of SARS-CoV-2 in amniotic fluid, placenta, neonatal throat and anal swab and breastmilk samples. Compared with non-pregnant women, pregnant women had a significantly lower proportion of fever (54·8% vs. 87·5%, p= 0.006), a shorter average interval from onset to hospitalization (7·80 ±7·0d vs. 13·2 ± 8·2d, p= 0.005), and a higher proportion of severe or critical COVID-19 (32·3% vs. 11·4%, p=0.039). Neutrophil-to-lymphocyte ratio (NLR) and systematic immune-inflammation-based prognostic index (SII) were significantly higher on admission in severe/critical pneumonia group than moderate pneumonia group. Amniotic fluid, placenta, neonatal throat and anal swab and breastmilk samples were tested for SARS-CoV-2 by RT-PCR and all results were negative.Implications of all the available evidenceThe clinical symptoms of COVID-19 in pregnant women were insidious and atypical, compared with those in non-pregnant patients. SII and NLR could be a useful marker to evaluate the severity of COVID-19. There was no evidence of vertical transmission during pregnancy with SARS-CoV-2 infection.

Sign in / Sign up

Export Citation Format

Share Document