Clinical and Imaging Evidence of Wuhan-Viral Pneumonia: A Large-Scale Prospective Cohort Study

2020 ◽  
Author(s):  
Liang Wang ◽  
Qiubai Li
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
Viral Pneumonia

scholarly journals High-Resolution Melting Is a Sensitive, Cost-Effective, Time-Saving Technique for BRAF V600E Detection in Thyroid FNAB Washing Liquid: A Prospective Cohort Study

2015 ◽  
Vol 4 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Marco Marino ◽  
Maria Laura Monzani ◽  
Giulia Brigante ◽  
Katia Cioni ◽  
Bruno Madeo ◽  
...  
Keyword(s):  
Cohort Study ◽  
High Resolution ◽  
Molecular Analysis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
High Resolution Melting ◽  
Cost Effective ◽  
Braf V600e Mutation ◽  
Braf V600e

Objective: The diagnostic accuracy of thyroid fine needle aspiration biopsy (FNAB) can be improved by the combination of cytological and molecular analysis. In this study, washing liquids of FNAB (wFNAB) were tested for the BRAF V600E mutation, using the sensitive and cost-effective technique called high-resolution melting (HRM). The aim was to demonstrate the feasibility of BRAF analysis in wFNAB and its diagnostic utility, combined with cytology. Design: Prospective cohort study. Methods: 481 patients, corresponding to 648 FNAB samples, were subjected to both cytological (on cells smeared onto a glass slide) and molecular analysis (on fluids obtained washing the FNAB needle with 1 ml of saline) of the same aspiration. BRAF V600E analysis was performed by HRM after methodological validation for application to wFNAB (technique sensitivity: 5.4%). Results: The cytological results of the FNAB were: 136 (21%) nondiagnostic (THY1); 415 (64%) benign (THY2); 80 (12.4%) indeterminate (THY3); 9 (1.4%) suspicious for malignancy (THY4); 8 (1.2%) diagnostic of malignancy (THY5). The BRAF V600E mutation was found in 5 THY2, 2 THY3, 6 THY4 and 6 THY5 samples. Papillary carcinoma diagnosis was histologically confirmed in all BRAF+ thyroidectomized patients. BRAF combined with cytology improved the diagnostic value compared to cytology alone in a subgroup of 74 operated patients. Conclusions: HRM was demonstrated to be a feasible method for BRAF analysis in wFNAB. Thanks to its sensitivity and cost-effectiveness, it might be routinely used on a large scale in clinical practice. In perspective, standby wFNAB samples could be analyzed a posteriori in case of indeterminate cytology and/or suspicious findings on ultrasound.

scholarly journals Positive Association between Dietary Inflammatory Index and the Risk of Osteoporosis: Results from the KoGES_Health Examinee (HEXA) Cohort Study

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1999 ◽  
Author(s):  
Hye Sun Kim ◽  
Cheongmin Sohn ◽  
Minji Kwon ◽  
Woori Na ◽  
Nitin Shivappa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
Similar Magnitude ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Menopausal Women ◽  
Osteoporosis Risk

Previous studies have found that diet’s inflammatory potential is related to various diseases. However, little is known about its relationship with osteoporosis. The aim of this study was to investigate the association between the dietary inflammatory index (DII®) and osteoporosis risk in a large-scale prospective cohort study in Korea. This prospective cohort study included 159,846 participants (men 57,740; women 102,106) from South Korea with a mean follow-up of 7.9 years. The DII was calculated through a validated semi-quantitative FFQ (SQFFQ), and information on osteoporosis was self-reported by the participants. Analyses were performed by using a multivariable Cox proportional hazard model. Higher DII scores were associated with higher osteoporosis risk (HR 1.33; 95% CI 1.12–1.58). In women, a higher DII score indicated a higher risk of osteoporosis (HR 1.33; 95% CI 1.11–1.59). However, a hazards ratio of similar magnitude in men was not significant (HR 1.32; 95% CI 0.64–2.71). Post-menopausal women had higher risks of osteoporosis for higher DII scores (HR 1.33; 95% CI 1.09–1.63), whereas among pre-menopausal women, the relationship was not statistically significant (HR 1.39; 95% CI 0.87–2.21). Also, there was an increase in osteoporosis risk when the DII increased among women participants with irregular physical activity (HR 1.53; 95% CI 1.17–2.01); however, there was no statistically significant increase in osteoporosis risk among women participants with regular physical activity (HR 1.19; 95% CI 0.93–1.52). A more pro-inflammatory diet was significantly associated with higher osteoporosis risk in women. Given the similar magnitude of the hazards ratio, studies with sufficient numbers of men are warranted.

Risk Factors for Gallstones and Cholecystectomy: a Large-Scale Population-Based Prospective Cohort Study in Japan

2021 ◽  
Author(s):  
Hugh Shunsuke Colvin ◽  
Takashi Kimura ◽  
Hiroyasu Iso ◽  
Satoyo Ikehara ◽  
Norie Sawada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
Population Based ◽  
Scale Population

scholarly journals The Korean Gastric Cancer Cohort Study: Study Protocol and Brief Results of a Large-Scale Prospective Cohort Study

2016 ◽  
Vol 16 (3) ◽  
pp. 182 ◽  
Author(s):  
Bang Wool Eom ◽  
Young-Woo Kim ◽  
Byung-Ho Nam ◽  
Keun Won Ryu ◽  
Hyun-Yong Jeong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Study Protocol ◽  
Prospective Cohort ◽  
Large Scale

A large-scale prospective cohort study on diet and cancer in the Netherlands

1990 ◽  
Vol 43 (3) ◽  
pp. 285-295 ◽  
Author(s):  
Piet A. van den Brandt ◽  
R.Alexandra Goldbohm ◽  
Pieter Van 'T Veer ◽  
Alexander Volovics ◽  
Rudolph J.J. Hermus ◽  
...  
Keyword(s):  
Cohort Study ◽  
The Netherlands ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
Diet And Cancer
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