Development and Validation of an Easy-to-Use Scoring System Developed from a Nomogram to Identify Malignant Pleural Effusion

2020 ◽  
Author(s):  
Sufei Wang ◽  
Shan Tian ◽  
Yuan Li ◽  
Na Zhan ◽  
Yingyun Guo ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Scoring System ◽  
Malignant Pleural Effusion ◽  
Development And Validation

scholarly journals Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion

EBioMedicine ◽  
2020 ◽  
Vol 58 ◽  
pp. 102924
Author(s):  
Sufei Wang ◽  
Shan Tian ◽  
Yuan Li ◽  
Na Zhan ◽  
Yingyun Guo ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Scoring System ◽  
Malignant Pleural Effusion ◽  
Development And Validation

scholarly journals Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis

2018 ◽  
Vol 19 (7) ◽  
pp. 930-939 ◽  
Author(s):  
Ioannis Psallidas ◽  
Nikolaos I Kanellakis ◽  
Stephen Gerry ◽  
Marie Laëtitia Thézénas ◽  
Philip D Charles ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Development And Validation

scholarly journals Development and Validation of a Scoring System for Early Diagnosis of Malignant Pleural Effusion Based on a Nomogram

2021 ◽  
Vol 11 ◽  
Author(s):  
Aihua Wu ◽  
Zhigang Liang ◽  
Songbo Yuan ◽  
Shanshan Wang ◽  
Weidong Peng ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Diagnostic Accuracy ◽  
Prediction Model ◽  
Scoring System ◽  
Malignant Pleural Effusion ◽  
Diagnostic Performance ◽  
External Validation ◽  
Training Set ◽  
Internal Validation ◽  
Validation Set

BackgroundThe diagnostic value of clinical and laboratory features to differentiate between malignant pleural effusion (MPE) and benign pleural effusion (BPE) has not yet been established.ObjectivesThe present study aimed to develop and validate the diagnostic accuracy of a scoring system based on a nomogram to distinguish MPE from BPE.MethodsA total of 1,239 eligible patients with PE were recruited in this study and randomly divided into a training set and an internal validation set at a ratio of 7:3. Logistic regression analysis was performed in the training set, and a nomogram was developed using selected predictors. The diagnostic accuracy of an innovative scoring system based on the nomogram was established and validated in the training, internal validation, and external validation sets (n = 217). The discriminatory power and the calibration and clinical values of the prediction model were evaluated.ResultsSeven variables [effusion carcinoembryonic antigen (CEA), effusion adenosine deaminase (ADA), erythrocyte sedimentation rate (ESR), PE/serum CEA ratio (CEA ratio), effusion carbohydrate antigen 19-9 (CA19-9), effusion cytokeratin 19 fragment (CYFRA 21-1), and serum lactate dehydrogenase (LDH)/effusion ADA ratio (cancer ratio, CR)] were validated and used to develop a nomogram. The prediction model showed both good discrimination and calibration capabilities for all sets. A scoring system was established based on the nomogram scores to distinguish MPE from BPE. The scoring system showed favorable diagnostic performance in the training set [area under the curve (AUC) = 0.955, 95% confidence interval (CI) = 0.942–0.968], the internal validation set (AUC = 0.952, 95% CI = 0.932–0.973), and the external validation set (AUC = 0.973, 95% CI = 0.956–0.990). In addition, the scoring system achieved satisfactory discriminative abilities at separating lung cancer-associated MPE from tuberculous pleurisy effusion (TPE) in the combined training and validation sets.ConclusionsThe present study developed and validated a scoring system based on seven parameters. The scoring system exhibited a reliable diagnostic performance in distinguishing MPE from BPE and might guide clinical decision-making.

scholarly journals Development and validation of the PET-CT score for diagnosis of malignant pleural effusion

2019 ◽  
Vol 46 (7) ◽  
pp. 1457-1467 ◽  
Author(s):  
Min-Fu Yang ◽  
Zhao-Hui Tong ◽  
Zhen Wang ◽  
Ying-Yi Zhang ◽  
Li-Li Xu ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Pet Ct ◽  
Development And Validation

scholarly journals Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score

Thorax ◽  
2014 ◽  
Vol 69 (12) ◽  
pp. 1098-1104 ◽  
Author(s):  
Amelia O Clive ◽  
Brennan C Kahan ◽  
Clare E Hooper ◽  
Rahul Bhatnagar ◽  
Anna J Morley ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Prognostic Score ◽  
Development And Validation

Diagnostic and Therapeutic Thoracoscopy (Videothoracoscopy) in Malignant Pleural Effusion - Our Experience

2008 ◽  
Vol 80 (1) ◽  
Author(s):  
Grzegorz Kacprzak ◽  
Jerzy Kołodziej ◽  
Konrad Pawełczyk ◽  
Marek Marciniak ◽  
Adam Rzechonek
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion
Sign in / Sign up

Export Citation Format

Share Document