Prevalence and Long-Term Outcome of Sub-Clinical Primary Sclerosing Cholangitis in Patients with Ulcerative Colitis

2020 ◽  
Author(s):  
Emma Culver ◽  
Helen K. Bungay ◽  
Margaret Betts ◽  
Colm Forde ◽  
Otto Buchel ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Sclerosing Cholangitis ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Prevalence and long‐term outcome of sub‐clinical primary sclerosing cholangitis in patients with ulcerative colitis

2020 ◽  
Vol 40 (11) ◽  
pp. 2744-2757
Author(s):  
Emma L. Culver ◽  
Helen K. Bungay ◽  
Margaret Betts ◽  
Colm Forde ◽  
Otto Buchel ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Term Outcome ◽  
Long Term Outcome

28 Impact of Ulcerative Colitis on the Long Term Outcome of Patients With Primary Sclerosing Cholangitis

2012 ◽  
Vol 142 (5) ◽  
pp. S-8 ◽  
Author(s):  
Udayakumar Navaneethan ◽  
Preethi GK Venkatesh ◽  
Saurabh Mukewar ◽  
Bret Lashner ◽  
Feza H. Remzi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Term Outcome ◽  
Long Term Outcome

Long-term outcome of treatment with cyclosporine IV for patients with intractable ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A624-A624 ◽  
Author(s):  
J ARTS ◽  
M ZEEGERS ◽  
G DHAENS ◽  
G VANASSCHE ◽  
M HIELE ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Long-Term Outcome of Patients with Ulcerative Colitis and Primary Non-response to Infliximab

2016 ◽  
Vol 10 (9) ◽  
pp. 1015-1023 ◽  
Author(s):  
Konstantinos Papamichael ◽  
Oliviane Rivals-Lerebours ◽  
Thomas Billiet ◽  
Niels Vande Casteele ◽  
Ann Gils ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Primary sclerosing cholangitis and pregnancy

2011 ◽  
Vol 1 (3) ◽  
pp. 55 ◽  
Author(s):  
Casper Q. Kammeijer ◽  
Robert A. De Man ◽  
Christianne J.M. De Groot
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Rare Case ◽  
Progressive Disease ◽  
High Dose ◽  
Term Outcome ◽  
Long Term Outcome ◽  
In Pregnancy

Primary sclerosing cholangitis is a progressive disease, and coincidentally in pregnancy it is rare. It is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure. A rare case of primary sclerosing cholangitis in pregnancy is presented. The course of the pregnancy was marked by threatened preterm delivery and exacerbation of cholestasis. She was successfully treated with ursodeoxycholic acid (UDCA). Although, primary sclerosing cholangitis has both maternal and fetal effects on pregnancy, the overall outcome is favorable. Only few cases have been reported using high dose ursodeoxycholic acid for primary sclerosing cholangitis in pregnancy, it often improves pruritus but has no protection against stillbirth. Data on the safety to the fetus or neonate and long-term outcome are scarce.

scholarly journals P421 Prognostic and therapeutic long-term outcome of patients with ulcerative proctitis: analysis from a large referral centre cohort study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S383-S384
Author(s):  
E Dubois ◽  
A Moens ◽  
J Sabino ◽  
M Ferrante ◽  
S Vermeire
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Remission ◽  
Therapeutic Outcome ◽  
Inactive Disease ◽  
Referral Centre ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Ulcerative Proctitis

Abstract Background Data about long-term prognostic and therapeutic outcome of patients with ulcerative proctitis (UP) are scarce. Real-world data are very important as these patients are usually excluded from participation in randomised controlled clinical trials. Methods All patients diagnosed with ulcerative colitis limited to the rectum (further defined as UP) and followed at our referral centre between 1998 and 2018, were identified via an automated search of electronic medical records and were reviewed for long-term therapeutic outcome. Treatment success was defined as clinical remission (complete disappearance of UP-related symptoms as judged by the treating physician) and endoscopic inactive disease (Mayo endoscopic sub-score of 0 or 1 on sigmoidoscopy) if available at last follow-up. Results From a total of 1561 patients with ulcerative colitis (UC), 168 patients with UP were identified (54% female, mean age at diagnosis 36 years). While the majority (118 patients or 70%) had proctitis since diagnosis, another 50/168 (30%) were diagnosed with left-sided colitis or extensive colitis but had a predominant disease course of proctitis afterwards. Nearly, all patients received treatment with 5-ASA but 71 patients (42%) were refractory to rectal ± oral therapy with 5-ASA and corticosteroids necessitating azathioprine in 41 patients (24%) and/or biological therapies in 59 patients (35%). Azathioprine was started as monotherapy in 34 patients. Anti-TNF was the first-line biological in 45 and vedolizumab in 14 patients. After a median follow-up of 76.5 months (IQR 34.3–143.8), clinical remission was observed in 143 patients (85%) and in 52/71 patients with 5-ASA refractory proctitis (73%). In this last group, clinical remission rates were significantly higher for patients treated with biologicals (44/59 or 75%) as compared with patients treated with azathioprine (8/34 or 24%; p < 0.0001). Conclusion Ten per cent of patients with ulcerative colitis from our referral centre cohort had disease confined to the rectum. With a median follow-up of more than 6 years, good clinical outcomes were recorded with 85% of patients achieving clinical remission. Nevertheless, more than one third needed escalation to biologicals to control the proctitis. Long-term outcome in patients on biologicals was superior to azathioprine. Our data do not suggest inferior outcomes for patients with proctitis compared with left-sided or extensive colitis.

Long Term Outcome of Ulcerative Colitis Patients Responders to Cyclosporine in the Biological Era

2017 ◽  
Vol 152 (5) ◽  
pp. S590
Author(s):  
Guillermo Bastida ◽  
Lluisa Sargatal ◽  
Valle García-Sánchez ◽  
Francisco Mesonero ◽  
Ana María Braitwaithe ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Term Outcome ◽  
Long Term Outcome
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