Salvianolic Acid a Protects Optic Nerve from Ischemia–Reperfusion Injury via Inhibiting Astrocytes and ROCK Activation

2019 ◽  
Author(s):  
Ke Mao ◽  
Xingwei Wu
Keyword(s):  
Optic Nerve ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Salvianolic Acid ◽  
Salvianolic Acid A

Salvianolic acid a attenuates limb ischemia/reperfusion injury in skeletal muscle of rats

2018 ◽  
Vol 97 ◽  
pp. 551-556 ◽  
Author(s):  
Yijia Xiang ◽  
Shiyong Ye ◽  
Changhong Cai ◽  
Junchong Chen ◽  
Xuyong Zhao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Salvianolic Acid ◽  
Salvianolic Acid A

scholarly journals Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion InjuryIn VivoandIn Vitro

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Huaying Fan ◽  
Liu Yang ◽  
Fenghua Fu ◽  
Hui Xu ◽  
Qinggang Meng ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Apoptotic Cell ◽  
Ischemia Reperfusion ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

Salvianolic acid A (SAA), one of the major active components of Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims to investigate the cardioprotection of SAAin vivoandin vitrousing the model of myocardial ischemia-reperfusion in rat and hydrogen peroxide (H2O2)-induced H9c2 rat cardiomyoblasts apoptosis. It was found that SAA significantly limited infarct size of ischemic myocardium when given immediately prior to reperfusion. SAA also significantly suppressed cellular injury and apoptotic cell death. Additionally, the results of western blot and phospho-specific antibody microarray analysis showed that SAA could up-regulate Bcl-2 expression and increase the phosphorylation of proteins such as Akt, p42/p44 extracellular signal-related kinases (Erk1/2), and their related effectors. The phosphorylation of those points was related to suppress apoptosis. In summary, SAA possesses marked protective effect on myocardial ischemia-reperfusion injury, which is related to its ability to reduce myocardial cell apoptosis and damage induced by oxidative stress. The protection is achieved via up-regulation of Bcl-2 expression and affecting protein phosphorylation. These findings indicate that SAA may be of value in cardioprotection during myocardial ischemia-reperfusion injury, which provide pharmacological evidence for clinical application.

scholarly journals Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135435 ◽  
Author(s):  
Yanping Deng ◽  
Min Yang ◽  
Feng Xu ◽  
Qian Zhang ◽  
Qun Zhao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Salvianolic Acid B ◽  
Ginsenoside Rg1 ◽  
Salvianolic Acid
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