Tumour Microenvironment-Based Molecular Profiling Reveals Ideal Candidates for High-Grade Serous Ovarian Cancer Immunotherapy

2019 ◽  
Author(s):  
Xiaofan Lu ◽  
Caoyu Ji ◽  
Liyun Jiang ◽  
Yang Wang ◽  
Yue Zhu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Immunotherapy ◽  
Tumour Microenvironment ◽  
Molecular Profiling ◽  
High Grade ◽  
Serous Ovarian Cancer

scholarly journals Integrated Molecular Profiling Studies to Characterize the Cellular Origins of High-Grade Serous Ovarian Cancer

2018 ◽  
Author(s):  
Kate Lawrenson ◽  
Marcos A.S. Fonseca ◽  
Felipe Segato ◽  
Janet M. Lee ◽  
Rosario I. Corona ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cells ◽  
Tumor Development ◽  
Molecular Profiling ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cell Of Origin ◽  
Ovarian Cancers ◽  
Integrative Analyses ◽  
Ovarian Surface Epithelial

AbstractHistorically, high-grade serous ovarian cancers (HGSOCs) were thought to arise from ovarian surface epithelial cells (OSECs) but recent data implicate fallopian tube secretory epithelial cells (FTSECs) as the major precursor. We performed transcriptomic and epigenomic profiling to characterize molecular similarities between OSECs, FTSECs and HGSOCs. Transcriptomic signatures of FTSECs were preserved in most HGSOCs reinforcing FTSECs as the predominant cell-of-origin; though an OSEC-like signature was associated with increased chemosensitivity (Padj= 0.03) and was enriched in proliferative-type tumors, suggesting a dualistic model for HGSOC origins. More super-enhancers (SEs) were shared between FTSECs and HGSOCs than between OSECS and HGSOCs (P< 2.2 × 10−16). SOX18, ELF3 and EHF transcription factors (TFs) coincided with HGSOC SEs and represent putative novel drivers of tumor development. Our integrative analyses support a predominantly fallopian origin for HGSOCs and indicate tumorigenesis may be driven by different TFs according to cell-of-origin.

scholarly journals The peritoneal tumour microenvironment of high‐grade serous ovarian cancer

2012 ◽  
Vol 227 (2) ◽  
pp. 136-145 ◽  
Author(s):  
D Andrew Leinster ◽  
Hagen Kulbe ◽  
Gemma Everitt ◽  
Richard Thompson ◽  
Mauro Perretti ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumour Microenvironment ◽  
High Grade ◽  
Serous Ovarian Cancer

scholarly journals CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 75130-75144 ◽  
Author(s):  
Fenne L. Komdeur ◽  
Maartje C.A. Wouters ◽  
Hagma H. Workel ◽  
Aline M. Tijans ◽  
Anouk L.J. Terwindt ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cells ◽  
Cancer Immunotherapy ◽  
High Grade ◽  
Serous Ovarian Cancer
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