scholarly journals The Antimalarial Natural Product Salinipostin a Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. Falciparum Parasites

2019 ◽  
Author(s):  
Euna Yoo ◽  
Christopher J. Schulze ◽  
Barbara H. Stokes ◽  
Ouma Onguka ◽  
Tomas Yeo ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Natural Product ◽  
Serine Hydrolases

scholarly journals The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

2019 ◽  
Author(s):  
Euna Yoo ◽  
Christopher J. Schulze ◽  
Barbara H. Stokes ◽  
Ouma Onguka ◽  
Tomas Yeo ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Lipid Metabolism ◽  
Natural Product ◽  
Resistance Mechanisms ◽  
Parasite Growth ◽  
Marine Natural Product ◽  
Monoacylglycerol Lipase ◽  
High Homology ◽  
Serine Hydrolase ◽  
Serine Hydrolases

SUMMARYSalinipostin A (Sal A) is a potent antimalarial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its targets in the Plasmodium falciparum parasite. All of the identified proteins contain α/β serine hydrolase domains, and several are essential for parasite growth. One of the essential targets displays high homology to human monoacylglycerol lipase (MAGL) and is able to process lipid esters including a MAGL acylglyceride substrate. This Sal A target is inhibited by the anti-obesity drug Orlistat, which disrupts lipid metabolism and produces disorganized and stalled schizonts similar to Sal A. Resistance selections yielded parasites that showed only minor reductions in sensitivity and that acquired mutations in a protein linked to drug resistance in Toxoplasma gondii. This inability to evolve efficient resistance mechanisms combined with the non-essentiality of human homologs makes the serine hydrolases identified here promising antimalarial targets.

scholarly journals The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

2020 ◽  
Vol 27 (2) ◽  
pp. 143-157.e5 ◽  
Author(s):  
Euna Yoo ◽  
Christopher J. Schulze ◽  
Barbara H. Stokes ◽  
Ouma Onguka ◽  
Tomas Yeo ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Natural Product ◽  
Serine Hydrolases

Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells

2019 ◽  
Vol 55 ◽  
pp. 296-304 ◽  
Author(s):  
Yunbing Shen ◽  
Shengnan Yang ◽  
Xueyan Hu ◽  
Man Zhang ◽  
Xiaoyao Ma ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Natural Product ◽  
Glucose And Lipid Metabolism ◽  
Hepatic Cells

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

Synthetic studies toward inducamide C

2021 ◽  
Author(s):  
Ardalan A. Nabi ◽  
Lydia M. Scott ◽  
Daniel P. Furkert ◽  
Jonathan Sperry
Keyword(s):  
Natural Product ◽  
Structural Revision ◽  
Synthetic Studies

The rare benzoxazepine ring in the alkaloid inducamide C is unstable and prone to rearrangement, indicating that structural revision of the natural product may be necessary.

Altered hepatic lipid metabolism in leptin-deficlent mice

2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid
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