Clinically Significant Fatigue: Prevalence, Predictors, and Health-Related Quality of Life in Adult Leukemia Patients

2019 ◽  
Author(s):  
Isamme AlFayyad ◽  
Mohamad Al-Tannir ◽  
Muawiyah Yaqub ◽  
Amani Abu-Shaheen
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Clinically Significant ◽  
Adult Leukemia

scholarly journals Mastoid cavity obliteration leads to a clinically significant improvement in health-related quality of life

2020 ◽  
Vol 277 (6) ◽  
pp. 1637-1643 ◽  
Author(s):  
Nora M. Weiss ◽  
David Bächinger ◽  
Jannik Botzen ◽  
Wilma Großmann ◽  
Robert Mlynski
Keyword(s):  
Quality Of Life ◽  
Mastoid Cavity ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Clinically Significant ◽  
Cavity Obliteration

scholarly journals Fatigue and depression predict reduced health-related quality of life in childhood-onset lupus

Lupus ◽  
2017 ◽  
Vol 27 (1) ◽  
pp. 124-133 ◽  
Author(s):  
C Donnelly ◽  
N Cunningham ◽  
J T Jones ◽  
L Ji ◽  
H I Brunner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
High Risk ◽  
Health Related Quality ◽  
Childhood Onset ◽  
Mood Symptoms ◽  
Related Quality ◽  
Health Related ◽  
Clinically Significant

We aimed to identify risk factors for persistently reduced health-related quality of life in childhood-onset lupus and describe a risk profile for persistently reduced health-related quality of life. At a tertiary rheumatology clinic, 50 childhood onset lupus patients were assessed twice, approximately six months apart. Measures of disease activity and patient-reported measures of health-related quality of life, pain, depressive symptoms, anxiety and disability were collected at each visit. At visits 1 and 2, respectively, clinically relevant fatigue was present in 66% and 56% of patients; clinically significant depressive symptoms in 26% and 24%; and clinically significant anxiety in 34% and 28%. Poorer health-related quality of life at follow-up was significantly predicted by higher fatigue and depressive symptoms at the initial visit. Using clinically relevant cut-offs for fatigue and depressive symptoms, patients were assigned to Low ( n = 27) or High Risk ( n = 23) groups. A profile of significantly greater pain, anxiety and coping difficulties was seen in the High Risk group. Routine assessment of fatigue and mood symptoms in youth with childhood-onset lupus could be helpful in identifying those at risk for persistently poor health-related quality of life. Integration of behavioral interventions to address fatigue and mood symptoms into medical care for such patients may be beneficial, but more research in this area is needed.

scholarly journals Modelling and estimation of health-related quality of life after hip fracture

2018 ◽  
Vol 7 (1) ◽  
pp. 1-5 ◽  
Author(s):  
N. Parsons ◽  
X. L. Griffin ◽  
J. Achten ◽  
T. J. Chesser ◽  
S. E. Lamb ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hip Fracture ◽  
Health Related Quality ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
Clinically Significant ◽  
Hip Trauma

Objectives This study investigates the reporting of health-related quality of life (HRQoL) in patients following hip fracture. We compare the relative merits and make recommendations for the use for two methods of measuring HRQoL; (i) including patients who died during follow-up and (ii) including survivors only. Methods The World Hip Trauma Evaluation has previously reported changes in HRQoL using EuroQol-5D for patients with hip fractures. We performed additional analysis to investigate the effect of including or excluding those patients who died during the first four months of the follow-up period. Results The dataset included 503 patients, 25 of whom died between 30 days and four months of injury. There was a statistically significant difference in 30-day HRQoL between those alive (mean 0.331 and standard deviation (SD) 0.360) and those dead (mean 0.156 and SD 0.421) by four months (independent-samples t-test; p 0.022). The estimated difference of 0.175 in HRQoL (95% confidence interval 0.025 to 0.325) was also highly clinically significant. Conclusion When reporting HRQoL for patients after a hip fracture, excluding patients who die during follow-up leads to an overestimate of the effects of the intervention or treatment pathway. We would recommend that death-adjusted estimates should be used routinely when reporting HRQoL in this population. Cite this article: N. Parsons, X. L. Griffin, J. Achten, T. J. Chesser, S. E. Lamb, M. L. Costa. Modelling and estimation of health-related quality of life after hip fracture: A re-analysis of data from a prospective cohort study. Bone Joint Res 2018;7:1–5.

Effect of complementary and alternative medicine on the survival and health-related quality of life among terminally ill cancer patients: A prospective cohort study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9066-9066
Author(s):  
Young Ho Yun ◽  
Myung Kyung Lee ◽  
Sang Min Park ◽  
Young Ae Kim
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Cancer Patients ◽  
Terminally Ill ◽  
Health Related Quality ◽  
Terminally Ill Cancer Patients ◽  
Related Quality ◽  
Health Related ◽  
Clinically Significant

9066 Background: Few have examined the effect of complementary and alternative medicine (CAM) use on survival and health-related quality of life (HRQOL) in cancer patients. Methods: From July 2005 to October 2006, we conducted a prospective cohort study of 481 terminally ill cancer patients at 11 university hospitals and the National Cancer Center in Korea. We assessed how the use of CAM affected HRQOL and survival. Results: In a follow-up of 481 patients and 163.8 person-years, we identified 466 deceased cases. On multivariate analyses, CAM users did not have better survival than nonusers (adjusted hazard ratio (aHR), 0.91; 95% confidence interval (CI), 0.74-1.10). Among biologically based therapies, dietary supplements (aHR, 0.70; 95% CI, 0.48–1.01) and ginseng (aHR, 0.73; 95% CI, 0.52–1.04) did not show significantly better survival. Among mind-body interventions, prayer showed significantly worse survival (aHR,1.56; 95% CI, 1.00–2.43). Clinically, CAM users reported significantly worse cognitive functioning (-11.6 v -1.3; p < 0.05) and fatigue (9.9 v -1.0; p < 0.05) than non-users. Compared with non-users in subgroup analysis, users of alternative medical treatments, prayer, vitamin supplements, mushrooms, or rice and cereal reported clinically significant worse changes in some HRQOL subscales. Conclusions: While CAM did not provide any definite survival benefit, CAM users reported clinically significant worse HRQOLs.

Health and Quality of Life Outcomes Among Patients Undergoing Surgery for End-Stage Ankle Arthritis

2019 ◽  
Vol 40 (10) ◽  
pp. 1129-1139 ◽  
Author(s):  
Shanika Rajapakshe ◽  
Jason M. Sutherland ◽  
Kevin Wing ◽  
Trafford Crump ◽  
Guiping Liu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ankle Arthrodesis ◽  
Depression Symptoms ◽  
Health Related Quality ◽  
Life Outcomes ◽  
Ankle Replacement ◽  
Related Quality ◽  
Health Related ◽  
Clinically Significant

Background:There is little research investigating which aspects of health-related quality of life change following ankle arthrodesis and total ankle replacement surgery. The objective of this study was to report on statistically and clinically relevant changes in multiple dimensions of health-related quality of life among patients undergoing ankle replacement or fusion surgery.Methods:This study was based on a prospective sample of ankle arthrodesis and total ankle replacement patients. Participants complete the Ankle Osteoarthritis Scale, EuroQoL’s EQ-5D-3L, the Patient Health Questionnaire–9, and the pain intensity, interference with enjoyment of life, and general activity pain instrument. Instruments were completed preoperatively and postoperatively. Multivariate regression models were used to measure the change in health-related quality of life outcomes, adjusting for demographic, clinical, and health service utilization.Results:Participants achieved statistically significant improvements in health-related quality of life in each domain of measurement. The majority of participants reported clinically significant improvement in pain. Mild depressive symptoms were common, and clinically significant improvement in depression symptoms occurred in 22% of patients. Gains in health were more pronounced among participants reporting the worst preoperative health in all domains quality of life measured.Conclusions:Pain showed a clinically important improvement among 64% of participants whereas 22% reported a clinically meaningful improvement in their depression symptoms postoperatively. Clinically significant gains in health-related quality of life were not experienced by all participants in all dimensions. Further research is warranted to better understand the failure of some patients to improve in dimensions of health studied.Level of Evidence:Level III, comparative study.

Sign in / Sign up

Export Citation Format

Share Document