Long Non-Coding RNA LINC00324 Exerts Pro-Tumorigenic Effects on Liver Cancer Stem Cells by Up-Regulating Fas Ligand via PU Box Binding Protein

2019 ◽  
Author(s):  
Jun Gao ◽  
Chao Dai ◽  
Xin Yu ◽  
Xiang-Bao Yin ◽  
Fan Zhou
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Fas Ligand ◽  
Binding Protein ◽  
Liver Cancer Stem Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis

2016 ◽  
Vol 64 (6) ◽  
pp. 1283-1294 ◽  
Author(s):  
Xue Wang ◽  
Wen Sun ◽  
Weifeng Shen ◽  
Mingyang Xia ◽  
Cheng Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Liver Cancer Stem Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway

Gene ◽  
2019 ◽  
Vol 684 ◽  
pp. 95-103 ◽  
Author(s):  
Zhangjun Cheng ◽  
Zhengqing Lei ◽  
Pinghua Yang ◽  
Anfeng Si ◽  
Daimin Xiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Liver Cancer Stem Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wang Yin ◽  
Dongxi Xiang ◽  
Tao Wang ◽  
Yumei Zhang ◽  
Cuong V. Pham ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
High Performance ◽  
Annexin V ◽  
Intracellular Concentration ◽  
Liver Cancer Stem Cells ◽  
Chemotherapy Agent ◽  
Future Strategy ◽  
Annexin V Assay

AbstractTwo ATP-binding cassette transporters, ABCB1/MDR1 and ABCG2/BCRP, are considered the most critical determinants for chemoresistance in hepatocellular carcinoma. However, their roles in the chemoresistance in liver cancer stem cells remain elusive. Here we explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer. We show that the inhibition of MDR1 or ABCG2 in Huh7 and PLC/PRF/5 cells using either pharmacological inhibitors or RNAi resulted in the elevated level of intracellular concentration of doxorubicin and the accompanied increased apoptosis as determined by confocal microscopy, high-performance liquid chromatography, flow cytometry, and annexin V assay. Notably, the inhibition of MDR1 or ABCG2 led to the reversal of the chemoresistance, as evident from the enhanced death of the chemoresistant liver cancer stem cells in tumorsphere-forming assays. Thus, the elevation of effective intracellular concentration of doxorubicin via the inhibition of MDR1 or ABCG2 represents a promising future strategy that transforms doxorubicin from a traditional chemotherapy agent into a robust killer of liver cancer stem cells for patients undergoing transarterial chemoembolization.

MK2206 overcomes the resistance of human liver cancer stem cells to sorafenib by inhibition of pAkt and upregulation of pERK

Tumor Biology ◽  
2015 ◽  
Vol 37 (6) ◽  
pp. 8047-8055 ◽  
Author(s):  
Beibei Zhai ◽  
Xiaofeng Zhang ◽  
Bin Sun ◽  
Lu Cao ◽  
Linlin Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

The clinical, prognostic and therapeutic significance of liver cancer stem cells and their markers

2021 ◽  
pp. 101664
Author(s):  
Izabela Zarębska ◽  
Arkadiusz Gzil ◽  
Justyna Durślewicz ◽  
Damian Jaworski ◽  
Paulina Antosik ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Liver Cancer Stem Cells
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