Blocking of PD-1/PD-L1 Promotes Hepatic Regeneration in Small-for-Size Liver Following Partial Resection Through Macrophage Polarization

2019 ◽  
Author(s):  
Xin Yan ◽  
Ji-Hua Shi ◽  
Jian-Feng Xue ◽  
Jia-Kai Zhang ◽  
Pei-Hao Wen ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Partial Resection ◽  
Hepatic Regeneration ◽  
Small For Size

Auxiliary two-staged partial resection (ASPIRE) LTx for end-stage liver disease to avoid small-for-size situations

2021 ◽  
Author(s):  
SM Brunner ◽  
FW Brennfleck ◽  
H Junger ◽  
B Knoppke ◽  
M Melter ◽  
...  
Keyword(s):  
Liver Disease ◽  
Partial Resection ◽  
End Stage Liver Disease ◽  
Small For Size ◽  
End Stage

scholarly journals Small-for-size liver transplanted into larger recipient: A model of hepatic regeneration

Hepatology ◽  
1994 ◽  
Vol 19 (1) ◽  
pp. 210-216 ◽  
Author(s):  
Antonio Francavilla ◽  
Qihua Zeng ◽  
Lorenzo Polimeno ◽  
Brian I. Carr ◽  
Dantong Sun ◽  
...  
Keyword(s):  
Hepatic Regeneration ◽  
Small For Size

scholarly journals Successful auxiliary two-staged partial resection liver transplantation (ASPIRE-LTx) for end-stage liver disease to avoid small-for-size situations

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stefan M. Brunner ◽  
Frank W. Brennfleck ◽  
Henrik Junger ◽  
Jirka Grosse ◽  
Birgit Knoppke ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Graft Function ◽  
Weight Ratio ◽  
Partial Resection ◽  
Liver Graft ◽  
Donor Pool ◽  
Left Liver ◽  
Small For Size ◽  
Graft Volume

Abstract Background Risks for living-liver donors are lower in case of a left liver donation, however, due to lower graft volume, the risk for small-for-size situations in the recipients increases. This study aims to prevent small-for-size situations in recipients using an auxiliary two-staged partial resection liver transplantation (LTX) of living-donated left liver lobes. Case presentation Two patients received a two-stage auxiliary LTX using living-donated left liver lobes after left lateral liver resection. The native extended right liver was removed in a second operation after sufficient hypertrophy of the left liver graft had occurred. Neither donor developed postoperative complications. In both recipients, the graft volume increased by an average of 105% (329 ml to 641 ml), from a graft-to-body-weight ratio of 0.54 to 1.08 within 11 days after LTX, so that the remnant native right liver could be removed. No recipient developed small-for-size syndrome; graft function and overall condition is good in both recipients after a follow-up time of 25 months. Conclusions Auxiliary two-staged partial resection LTX using living-donor left lobes is technically feasible and can prevent small-for-size situation. This new technique can expand the potential living-donor pool and contributes to increase donor safety.

scholarly journals Corosolic Acid Inhibits Tumor Growth without Compromising ALPPS-induced Liver Regeneration in Rats

2020 ◽  
Author(s):  
Jinwei zhao ◽  
xueyue luo ◽  
weiyi zhao ◽  
hong zhou ◽  
hongyue xu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Liver Regeneration ◽  
Macrophage Polarization ◽  
Hepatic Regeneration ◽  
M2 Macrophage ◽  
Portal Vein Ligation ◽  
Sprague Dawley ◽  
Regeneration Rate ◽  
Sprague Dawley Rats ◽  
Corosolic Acid

Abstract BackgroudThe associating liver partition and portal vein ligation (ALPPS) technique is a promising strategy for unresectable tumors without sufficient future liver remnants (FLRs). Criticism has focused on its stimulation of tumor growth. This study explores the effect of corosolic acid (CA) on inhibiting tumor growth without compromising ALPPS-induced liver regeneration and investigates its possible mechanism.MethodsThe ALPPS procedure was performed in Sprague-Dawley rats with orthotopic liver cancer. Blood, tumor and FLR samples in different group were collected.ResultsThe tumor weight in the implantation/ALPPS/CA group was lower than that in the implantation/ALPPS group (p < 0.05). On postoperative day 15, the hepatic regeneration rate and the expression of Ki67+ hepatocytes in the FLRs increased significantly in the group that underwent ALPPS. The number of CD86+ macrophages increased in the FLRs and tumors of the groups that underwent the ALPPS procedure. Additionally, the number of CD206+ macrophages was higher than the number of CD86+ macrophages in the tumors of the implantation group and the implantation/ALPPS group (p < 0.01, respectively); however, the opposite results were observed in the CA groups. The administration of CA downregulated the expression of TGF-β, CD31 and PD-1, whereas it increased the number of CD8+ lymphocytes in tumors.ConclusionsCA inhibits tumor growth without compromising ALPPS-induced liver regeneration. This result may be attributed to the CA-induced downregulation of PD-1 and TGF-β expression and the increased CD8+ lymphocyte infiltration in tumor tissue, associated with the suppression of M2 macrophage polarization.

Impaired hepatic regeneration by ischemic preconditioning in a rat model of small-for-size liver transplantation

2007 ◽  
Vol 18 (1) ◽  
pp. 37-43 ◽  
Author(s):  
AiHua Yao ◽  
XiangCheng Li ◽  
LiYong Pu ◽  
JiWei Zhong ◽  
XianZhong Liu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ischemic Preconditioning ◽  
Rat Model ◽  
Hepatic Regeneration ◽  
Small For Size
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