Lung Function and Structure of Young Adults Following Neonatal Chronic Lung Disease Suggests Potential for Pulmonary Repair

2019 ◽  
Author(s):  
Yvo M. Santema ◽  
Jan Stolk ◽  
Mady Los ◽  
Berend C. Stoel ◽  
Rula Tsonaka ◽  
...  
Keyword(s):  
Young Adults ◽  
Lung Function ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Neonatal Chronic Lung Disease

Longitudinal follow-up of lung function from childhood to adolescence in prematurely born patients with neonatal chronic lung disease

1996 ◽  
Vol 21 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Anastassios C. Koumbourlis ◽  
Etsuro K. Motoyama ◽  
Rebecca L. Mutich ◽  
George B. Mallory ◽  
Stephen A. Walczak ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Neonatal Chronic Lung Disease

Neonatal Chronic Lung Disease in Extremely Immature Baboons

1999 ◽  
Vol 160 (4) ◽  
pp. 1333-1346 ◽  
Author(s):  
JACQUELINE J. COALSON ◽  
VICKI T. WINTER ◽  
THERESA SILER-KHODR ◽  
BRADLEY A. YODER
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Neonatal Chronic Lung Disease

scholarly journals Early Changes and Indicators Characterizing Lung Aging in Neonatal Chronic Lung Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Jennifer Sucre ◽  
Lena Haist ◽  
Charlotte E. Bolton ◽  
Anne Hilgendorff
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Health Care Professionals ◽  
Treatment Strategies ◽  
Oxygen Toxicity ◽  
Growth Factor Signaling ◽  
Inflammatory Processes ◽  
Long Term Consequences ◽  
Neonatal Chronic Lung Disease

Infants suffering from neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, are facing long-term consequences determined by individual genetic background, presence of infections, and postnatal treatment strategies such as mechanical ventilation and oxygen toxicity. The adverse effects provoked by these measures include inflammatory processes, oxidative stress, altered growth factor signaling, and remodeling of the extracellular matrix. Both, acute and long-term consequences are determined by the capacity of the immature lung to respond to the challenges outlined above. The subsequent impairment of lung growth translates into an altered trajectory of lung function later in life. Here, knowledge about second and third hit events provoked through environmental insults are of specific importance when advocating lifestyle recommendations to this patient population. A profound exchange between the different health care professionals involved is urgently needed and needs to consider disease origin while future monitoring and treatment strategies are developed.

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