Clinico-Radiological Characteristic-Based Machine Learning in Reducing Unnecessary Prostate Biopsies of PI-RADS 3 Lesions with Dual Validation

2019 ◽  
Author(s):  
YanSheng Kan ◽  
Qing Zhang ◽  
Jiange Hao ◽  
Wei Wang ◽  
Junlong Zhuang ◽  
...  
2020 ◽  
Vol 30 (11) ◽  
pp. 6274-6284 ◽  
Author(s):  
Yansheng Kan ◽  
Qing Zhang ◽  
Jiange Hao ◽  
Wei Wang ◽  
Junlong Zhuang ◽  
...  

2020 ◽  
Vol 203 ◽  
pp. e342
Author(s):  
Nathan J Paulson* ◽  
Tal Zeevi ◽  
Maria Papademetris ◽  
John A Onofrey ◽  
Preston C Sprenkle ◽  
...  

Author(s):  
David Dov ◽  
Serge Assaad ◽  
Ameer Syedibrahim ◽  
Jonathan Bell ◽  
Jiaoti Huang ◽  
...  

Context.— Prostate cancer is a common malignancy, and accurate diagnosis typically requires histologic review of multiple prostate core biopsies per patient. As pathology volumes and complexity increase, new tools to improve the efficiency of everyday practice are keenly needed. Deep learning has shown promise in pathology diagnostics, but most studies silo the efforts of pathologists from the application of deep learning algorithms. Very few hybrid pathologist–deep learning approaches have been explored, and these typically require complete review of histologic slides by both the pathologist and the deep learning system. Objective.— To develop a novel and efficient hybrid human–machine learning approach to screen prostate biopsies. Design.— We developed an algorithm to determine the 20 regions of interest with the highest probability of malignancy for each prostate biopsy; presenting these regions to a pathologist for manual screening limited the initial review by a pathologist to approximately 2% of the tissue area of each sample. We evaluated this approach by using 100 biopsies (29 malignant, 60 benign, 11 other) that were reviewed by 4 pathologists (3 urologic pathologists, 1 general pathologist) using a custom-designed graphical user interface. Results.— Malignant biopsies were correctly identified as needing comprehensive review with high sensitivity (mean, 99.2% among all pathologists); conversely, most benign prostate biopsies (mean, 72.1%) were correctly identified as needing no further review. Conclusions.— This novel hybrid system has the potential to efficiently triage out most benign prostate core biopsies, conserving time for the pathologist to dedicate to detailed evaluation of malignant biopsies.


2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Ohad Kott* ◽  
Drew Linsley ◽  
Ali Amin ◽  
Andreas Karagounis ◽  
Dragan Golijanin ◽  
...  

2020 ◽  
Vol 43 ◽  
Author(s):  
Myrthe Faber

Abstract Gilead et al. state that abstraction supports mental travel, and that mental travel critically relies on abstraction. I propose an important addition to this theoretical framework, namely that mental travel might also support abstraction. Specifically, I argue that spontaneous mental travel (mind wandering), much like data augmentation in machine learning, provides variability in mental content and context necessary for abstraction.


2007 ◽  
Vol 177 (4S) ◽  
pp. 560-560
Author(s):  
Robert A. Linden ◽  
Paul R. Gittens ◽  
Flemming Forsberg ◽  
Edouard J. Trabulsi ◽  
Leonard G. Gomella ◽  
...  

2020 ◽  
Author(s):  
Mohammed J. Zaki ◽  
Wagner Meira, Jr
Keyword(s):  

2020 ◽  
Author(s):  
Marc Peter Deisenroth ◽  
A. Aldo Faisal ◽  
Cheng Soon Ong
Keyword(s):  

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