In Vivo Proton Magnetic Resonance Spectroscopy in a Rat Model of Human Retinitis Pigmentosa: A Longitudinal Study for Progressive Metabolic Alterations in the Visual Cortex

2019 ◽  
Author(s):  
Zebin Xiao ◽  
Zuohua Tang ◽  
Xinghuai Sun ◽  
Rong Wang ◽  
Weijun Tang ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Rat Model ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Metabolic Alterations

Neurometabolic alterations in a depression-like rat model of chronic forced swimming stress using in vivo proton magnetic resonance spectroscopy at 7 T

2017 ◽  
Vol 41 (S1) ◽  
pp. S544-S545
Author(s):  
C.H. Yoo ◽  
K.H. Song ◽  
S.I. Lim ◽  
D.C. Woo ◽  
B.Y. Choe
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Metabolic Alterations ◽  
Behavioral Despair ◽  
Echo Time ◽  
Short Echo Time

Although recent investigations of major depressive disorder (MDD) have focused on the monoaminergic system, accumulating evidence suggests that alternative pathophysiological models of MDD and treatment options for patients with MDD are needed. Animals subjected to chronic forced swim stress (CFSS) develop behavioral despair. The purpose of this study was to investigate the in vivo effects of CFSS in the rat prefrontal cortex (PFC) with 7 T and short-echo-time proton magnetic resonance spectroscopy (1H MRS). Ten male Wistar rats underwent 14 days of CFSS, and in vivo1H MRS and forced swim tests were performed before and after CFSS. Point-resolved spectroscopy was used to quantify metabolite levels in the rat PFC. The spectral analyses showed that in vivo1H MRS can be used to reliably assess the Glu system. The rats showed significantly increased immobility times and decreased climbing times in the FST after CFSS, which suggested that the rats developed behavioral despair. The pre-CFSS and post-CFSS Glu and Gln levels did not significantly differ (P > 0.050). The levels of myo-inositol, total choline, and N-acetylaspartate, myo-inositol/creatine, and total choline/creatine increased significantly (P < 0.050). Similar findings have been reported in patients with MDD. Taken together, these results suggested that the CFSS-induced metabolic alterations were similar to those found in patients and that high-field and short-echo-time in vivo1H MRS can be used to investigate depression-induced metabolic alterations. Such investigations might provide alternative insights into the nonmonoaminergic pathophysiology and treatment of depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals 81 IN VIVO PROTON MAGNETIC RESONANCE SPECTROSCOPY (1H-MRS) IN CYSTIC LEUCOMALACIA OF INFANCY

1994 ◽  
Vol 36 (1) ◽  
pp. 16A-16A
Author(s):  
Floris Groenendaal ◽  
Paula Eken ◽  
Jeroen Van Der Grond ◽  
Karin Rademaker ◽  
Linda S De Vries
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Mrs

scholarly journals Discrimination of Brin Abscess and Cystic Tumor by In Vivo Proton Magnetic Resonance Spectroscopy.

2001 ◽  
Vol 41 (3) ◽  
pp. 121-126 ◽  
Author(s):  
Osamu KADOTA ◽  
Kanehisa KOHNO ◽  
Shiro OHUE ◽  
Yoshiaki KUMON ◽  
Saburo SAKAKI ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Cystic Tumor ◽  
Resonance Spectroscopy
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