Metabolic Syndrome and Risk of Lung Cancer: An Analysis of Korean National Health Insurance Corporation Database

2019 ◽  
Author(s):  
Sooim Sin ◽  
Chang-Hoon Lee ◽  
Sun Mi Choi ◽  
Kyung-Do Han ◽  
Jinwoo Lee
Author(s):  
Sooim Sin ◽  
Chang-Hoon Lee ◽  
Sun Mi Choi ◽  
Kyung-Do Han ◽  
Jinwoo Lee

Abstract Introduction Metabolic syndrome is known to increase the risk of several cancers. However, the association between lung cancer and metabolic syndrome remains unclear. Thus, we investigated the impact of metabolic syndrome on the incidence of lung cancer. Methods This study enrolled participants in a health screening program provided by the Korean National Health Insurance Service between January 2009 and December 2012. The incidence of lung cancer was observed until December 2016. We analyzed the risk of lung cancer according to the presence of metabolic syndrome, metabolic syndrome components, and number of metabolic syndrome components. Results During the study, 45 635 new cases of lung cancer were recorded among 9 586 753 participants. The presence of metabolic syndrome and all its components was positively associated with the risk of lung cancer in men after multivariate adjustment (hazard ratio [HR] of metabolic syndrome 1.15; 95% confidence interval [CI], 1.12-1.18). The risk of lung cancer increased with the number of components present. The effect of metabolic syndrome on the increasing risk of lung cancer is may be higher in underweight male ever-smokers than in other participants. Conclusion Metabolic syndrome was associated with an increased risk of lung cancer in men. Moreover, the higher the number of metabolic syndrome components, the higher the risk of lung cancer.


2020 ◽  
Author(s):  
YEO JIN KIM ◽  
Sang Mi Kim ◽  
Dae Hyun Jeong ◽  
Sang-Kyu Lee ◽  
Moo-Eob Ahn ◽  
...  

Abstract BackgroundMetabolic syndrome is a cluster of conditions that occur together, increasing the risk of cardiovascular disease. However, the relationshipbetween metabolic syndrome and dementia has remained controversial. Using nationwide population cohort data, we investigated the associationbetween metabolic syndrome and dementia,according to the dementia type.MethodsWe analyzed data of 84,144 individuals,in the aged group of more than 60 years,between January 1, 2009,to December 31, 2009, at Gangwon province by using the information of the(Korean) National Health Insurance Service. After eight years of gap, in 2017, we investigated the relationship between metabolic syndrome and dementia. We classified Dementia either as dementia of the Alzheimer type (AD) or vascular dementia (VD). AD and VD were defined according to criteria in the International Classification of Disease, Tenth Revision, Clinical Modification codes.ResultsMetabolic syndrome was associated with AD, while it was not associated with VD. All five components of metabolic syndrome were associated with AD, independently. However, among components of metabolic syndrome, only the high glucose level was associated with VD. Body Mass Index (BMI), fasting glucose and smoking were also associated with AD. A history of the previous stroke was associated with both AD and VD.ConclusionsMetabolic syndrome was associated with AD, while was not associated with VD. VD was associated only with several risk factors that could affect the vascular state rather than a metabolic syndrome. We suggested that the effect of metabolic syndrome on dementia would be different depending on the type of dementia.


2012 ◽  
Vol 27 (Suppl) ◽  
pp. S21 ◽  
Author(s):  
Myoung Sheen Kang ◽  
Hoo Sun Jang ◽  
Minjee Lee ◽  
Eun-Cheol Park

2021 ◽  
pp. e2021010
Author(s):  
Sunyong Yoo ◽  
Dong-Wook Kim ◽  
Young-Eun Kim ◽  
JongHeon Park ◽  
Yeon-Yong Kim ◽  
...  

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