Indented Polymer Microparticles with Shape Variety Reminiscent of Poikilocytosis for Intratumoral Drug Delivery after Transarterial Chemo-Embolization

2019 ◽  
Author(s):  
Abderazak Benzina ◽  
Aigerim Karina ◽  
Marion Guillonneau ◽  
Samal Tazhibayeva ◽  
Haiyan Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Microparticles ◽  
Intratumoral Drug Delivery

Stimuli-responsive hydrogels for intratumoral drug delivery

2021 ◽  
Author(s):  
Ana C. Marques ◽  
Paulo J. Costa ◽  
Sérgia Velho ◽  
Maria H. Amaral
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Hydrogels ◽  
Intratumoral Drug Delivery

scholarly journals Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma

Nanoscale ◽  
2020 ◽  
Vol 12 (46) ◽  
pp. 23838-23850
Author(s):  
Giulia Brachi ◽  
Javier Ruiz-Ramírez ◽  
Prashant Dogra ◽  
Zhihui Wang ◽  
Vittorio Cristini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Intratumoral Injection ◽  
Embedded Nanoparticles ◽  
Intratumoral Drug Delivery

Intratumoral drug delivery is a promising approach for the treatment of glioblastoma multiforme (GBM).

scholarly journals Affinity-based polymers provide long-term immunotherapeutic drug delivery across particle size ranges optimal for macrophage targeting

2019 ◽  
Author(s):  
Nathan A. Rohner ◽  
Linda Purdue ◽  
Horst A. von Recum
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Particle Diameter ◽  
Raw 264.7 Macrophages ◽  
Similar Drug ◽  
Macro Scale ◽  
Immunomodulatory Drug ◽  
Polymer Microparticles ◽  
Post Synthesis

AbstractLong term drug delivery to specific arms of the immune system can be technically challenging to provide limited off-target toxicity as well as prolonged delivery and specific cellular targeting given the limits of current drug delivery systems. In this work, we demonstrate the robustness of a cyclodextrin (CD) polymer platform that can extend immunomodulatory drug delivery via affinity interactions to promote long-term, sustained release at multiple size scales. The parameter space of synthesis variables (pre-incubation and stirring speed) and post-synthesis grinding effects on resulting particle diameter were characterized. We demonstrate that polymerized CD forms exhibit size-independent release profiles of the small molecule drug lenalidomide (LND) and can provide similar drug delivery profiles as macro-scale CD polymer disks. CD polymer microparticles and nanoparticles demonstrated no significant cytotoxicity as compared to the base CD macromonomer when co-incubated with fibroblasts. Uptake of ground CD nanoparticles was significantly higher following incubation with RAW 264.7 macrophages in culture over originally synthesized, larger CD microparticles. Thus, the affinity/structure properties afforded by polymerized CD allow particle size to be modified to affect cellular uptake profiles independently of drug release rate for applications in cell-targeted drug delivery.

scholarly journals Abstract No. 430 Self-assembling hydrogel platform improves intratumoral drug delivery and retention

2020 ◽  
Vol 31 (3) ◽  
pp. S192
Author(s):  
D. Leach ◽  
N. Muñoz ◽  
C. Dupuis ◽  
M. Williams ◽  
K. Dixon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembling ◽  
Intratumoral Drug Delivery

scholarly journals Modeling doxorubicin transport to improve intratumoral drug delivery to RF ablated tumors

2007 ◽  
Vol 124 (1-2) ◽  
pp. 11-19 ◽  
Author(s):  
Brent D. Weinberg ◽  
Ravi B. Patel ◽  
Agata A. Exner ◽  
Gerald M. Saidel ◽  
Jinming Gao
Keyword(s):  
Drug Delivery ◽  
Intratumoral Drug Delivery

MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome

Biomaterials ◽  
2011 ◽  
Vol 32 (27) ◽  
pp. 6570-6578 ◽  
Author(s):  
Tatsuaki Tagami ◽  
Warren D. Foltz ◽  
Mark J. Ernsting ◽  
Carol M. Lee ◽  
Ian F. Tannock ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Effect ◽  
Thermosensitive Liposome ◽  
Intratumoral Drug Delivery

Mesoporous iron-carboxylate metal–organic frameworks synthesized by the double-template method as a nanocarrier platform for intratumoral drug delivery

2017 ◽  
Vol 5 (5) ◽  
pp. 1032-1040 ◽  
Author(s):  
Zhengfei Wu ◽  
Na Hao ◽  
Hai Zhang ◽  
Zhaoyuan Guo ◽  
Rong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Therapeutic Efficacy ◽  
Metal Organic Frameworks ◽  
Template Method ◽  
Local Chemotherapy ◽  
Metal Organic ◽  
Iron Carboxylate ◽  
Intratumoral Drug Delivery

The DOX-loaded mesoMOFs exhibit excellent therapeutic efficacy and low side effects in local chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document