Does Fine Particulate Matter Exacerbate Cardiovascular Events Among Patients with Chronic Kidney Disease?

2019 ◽  
Author(s):  
Jinjun Ran ◽  
Aimin Yang ◽  
Shengzhi Sun ◽  
Lefei Han ◽  
Shi Zhao ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Particulate Matter ◽  
Kidney Disease ◽  
Cardiovascular Events ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals The global and national burden of chronic kidney disease attributable to ambient fine particulate matter air pollution: a modelling study

2020 ◽  
Vol 5 (3) ◽  
pp. e002063 ◽  
Author(s):  
Benjamin Bowe ◽  
Elena Artimovich ◽  
Yan Xie ◽  
Yan Yan ◽  
Miao Cai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Particulate Matter ◽  
Kidney Disease ◽  
Fine Particulate Matter ◽  
Yield Reduction ◽  
Global Burden ◽  
Exposure Response ◽  
Fine Particulate ◽  
Life Years ◽  
National Burden

IntroductionWe aimed to integrate all available epidemiological evidence to characterise an exposure–response model of ambient fine particulate matter (PM2.5) and the risk of chronic kidney disease (CKD) across the spectrum of PM2.5 concentrations experienced by humans. We then estimated the global and national burden of CKD attributable to PM2.5.MethodsWe collected data from prior studies on the association of PM2.5 with CKD and used an integrative meta-regression approach to build non-linear exposure–response models of the risk of CKD associated with PM2.5 exposure. We then estimated the 2017 global and national incidence, prevalence, disability-adjusted life-years (DALYs) and deaths due to CKD attributable to PM2.5 in 194 countries and territories. Burden estimates were generated by linkage of risk estimates to Global Burden of Disease study datasets.ResultsThe exposure–response function exhibited evidence of an increase in risk with increasing PM2.5 concentrations, where the rate of risk increase gradually attenuated at higher PM2.5 concentrations. Globally, in 2017, there were 3 284 358.2 (95% UI 2 800 710.5 to 3 747 046.1) incident and 122 409 460.2 (108 142 312.2 to 136 424 137.9) prevalent cases of CKD attributable to PM2.5, and 6 593 134.6 (5 705 180.4 to 7 479 818.4) DALYs and 211 019.2 (184 292.5 to 236 520.4) deaths due to CKD attributable to PM2.5. The burden was disproportionately borne by low income and lower middle income countries and exhibited substantial geographic variability, even among countries with similar levels of sociodemographic development. Globally, 72.8% of prevalent cases of CKD attributable to PM2.5 and 74.2% of DALYs due to CKD attributable to PM2.5 were due to concentrations above 10 µg/m3, the WHO air quality guidelines.ConclusionThe global burden of CKD attributable to PM2.5 is substantial, varies by geography and is disproportionally borne by disadvantaged countries. Most of the burden is associated with PM2.5 levels above the WHO guidelines, suggesting that achieving those targets may yield reduction in CKD burden.

scholarly journals Long-Term Exposure to Ambient Fine Particulate Matter and Chronic Kidney Disease: A Cohort Study

2018 ◽  
Vol 126 (10) ◽  
pp. 107002 ◽  
Author(s):  
Ta-Chien Chan ◽  
Zilong Zhang ◽  
Bo-Cheng Lin ◽  
Changqing Lin ◽  
Han-Bing Deng ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Particulate Matter ◽  
Kidney Disease ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals Transient risk of ambient fine particulate matter on hourly cardiovascular events in Tainan City, Taiwan

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238082
Author(s):  
Pei-Chih Wu ◽  
Tain-Junn Cheng ◽  
Cheng-Pin Kuo ◽  
Joshua S. Fu ◽  
Hsin-Chih Lai ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Cardiovascular Events ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Tainan City

scholarly journals Fine Particulate Matter (PM2.5) and Chronic Kidney Disease

2021 ◽  
pp. 183-215
Author(s):  
Yilin Zhang ◽  
Dongwei Liu ◽  
Zhangsuo Liu
Keyword(s):  
Chronic Kidney Disease ◽  
Particulate Matter ◽  
Kidney Disease ◽  
Fine Particulate Matter ◽  
Kidney Damage ◽  
Current Status ◽  
Global Database ◽  
Government Organizations ◽  
Scientific Papers ◽  
The Impact

AbstractThe impact of ambient particulate matter (PM) on public health has become a great global concern, which is especially prominent in developing countries. For health purposes, PM is typically defined by size, with the smaller particles having more health impacts. Particles with a diameter <2.5 μm are called PM2.5. Initial research studies have focused on the impact of PM2.5 on respiratory and cardiovascular diseases; nevertheless, an increasing number of data suggested that PM2.5 may affect every organ system in the human body, and the kidney is of no exception. The kidney is vulnerable to particulate matter because most environmental toxins are concentrated by the kidney during filtration. According to the high morbidity and mortality related to chronic kidney disease, it is necessary to determine the effect of PM2.5 on kidney disease and its mechanism that needs to be identified. To understand the current status of PM2.5 in the atmosphere and their potential harmful kidney effects in different regions of the world this review article was prepared based on peer-reviewed scientific papers, scientific reports, and database from government organizations published after the year 1998. In this review, we focus on the worldwide epidemiological evidence linking PM2.5 with chronic kidney disease and the effect of PM2.5 on the chronic kidney disease (CKD) progression. At the same time, we also discuss the possible mechanisms of PM2.5 exposure leading to kidney damage, in order to emphasize the contribution of PM2.5 to kidney damage. A global database on PM2.5 and kidney disease should be developed to provide new ideas for the prevention and treatment of kidney disease.

scholarly journals The Benefits of Intensive Versus Standard Blood Pressure Treatment According to Fine Particulate Matter Air Pollution Exposure

Hypertension ◽  
2021 ◽  
Vol 77 (3) ◽  
pp. 813-822
Author(s):  
Sadeer G. Al-Kindi ◽  
Robert D. Brook ◽  
Udayan Bhatt ◽  
Michael Brauer ◽  
William C. Cushman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Particulate Matter ◽  
Cardiovascular Events ◽  
Primary Outcome ◽  
Fine Particulate Matter ◽  
Large Body ◽  
Ambient Air ◽  
Hazard Ratio ◽  
Fine Particulate

Fine particulate matter <2.5 µm (PM 2.5 ) air pollution is implicated in global mortality, especially from cardiovascular causes. A large body of evidence suggests a link between PM 2.5 and elevation in blood pressure (BP), with the latter implicated as a potential mediator of cardiovascular events. We sought to determine if the outcomes of intensive BP lowering (systolic BP <120 mm Hg) on cardiovascular events are modified by PM 2.5 exposure in the SPRINT (Systolic BP Intervention Trial). We linked annual PM 2.5 exposure estimates derived from an integrated model to subjects participating in SPRINT. We evaluated the effect of intensive BP lowering by PM 2.5 exposure on the primary outcome in SPRINT using cox-proportional hazard models. A total of 9286 participants were linked to PM 2.5 levels (mean age 68±9 years). Intensive BP-lowering decreased risk of the primary outcome more among patients exposed to higher PM 2.5 ( P interaction =0.047). The estimate for lowering of primary outcome was numerically lower in the highest than in the lower quintiles. The benefits of intensive BP-lowering were larger among patients chronically exposed to PM 2.5 levels above US National Ambient Air Quality Standards of 12 µg/m 3 (hazard ratio, 0.47 [95% CI, 0.29–0.74]) compared with those living in cleaner locations (hazard ratio, 0.81 [95% CI, 0.68–0.97]), P interaction =0.037. This exploratory nonprespecified post hoc analysis of SPRINT suggests that the benefits of intensive BP lowering on the primary outcome was greater in patients exposed to higher PM 2.5 , suggesting that the magnitude of benefit may depend upon the magnitude of antecedent PM 2.5 exposure.

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