Lysyl Oxidase Enhances Warburg Effect to Mediate Reciprocal Interactions between Tumor Cells and Cancer Associated Fibroblasts in Liver Metastasis of Gastric Cancer

2019 ◽  
Author(s):  
Qing Li ◽  
Chunchao Zhu ◽  
Bo Ni ◽  
Zizhen Zhang ◽  
Shuheng Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastasis ◽  
Tumor Cells ◽  
Warburg Effect ◽  
Lysyl Oxidase ◽  
Cancer Associated Fibroblasts ◽  
Reciprocal Interactions

scholarly journals Curcumin inhibits liver metastasis of gastric cancer through reducing circulating tumor cells

Aging ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1501-1509 ◽  
Author(s):  
Xixi Gu ◽  
Qiqi Zhang ◽  
Wei Zhang ◽  
Liang Zhu
Keyword(s):  
Gastric Cancer ◽  
Liver Metastasis ◽  
Tumor Cells ◽  
Circulating Tumor Cells

Current Study of RhoA and Associated Signaling Pathways in Gastric Cancer

2020 ◽  
Vol 15 (7) ◽  
pp. 607-613 ◽  
Author(s):  
Haiping Liu ◽  
Yiqian Liu ◽  
Xiaochuan Zhang ◽  
Xiaodong Wang
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Signaling Pathways ◽  
Tumor Cells ◽  
Actin Polymerization ◽  
Cell Transformation ◽  
Cell Movement ◽  
Invasion And Metastasis ◽  
Common Cancer

Gastric cancer (GC) is the fourth-most common cancer in the world, with an estimated 1.034 million new cases in 2015, and the third-highest cause of cancer deaths, estimated at 785,558, in 2014. Early diagnosis and treatment greatly affect the survival rate in patients with GC: the 5‐year survival rate of early GC reaches 90%‐95%, while the mortality rate significantly increases if GC develops to the late stage. Recently, studies for the role of RhoA in the diseases have become a hot topic, especially in the development of tumors. A study found that RhoA can regulate actin polymerization, cell adhesion, motor-myosin, cell transformation, and the ability to participate in the activities of cell movement, proliferation, migration, which are closely related to the invasion and metastasis of tumor cells. However, the specific role of RhoA in tumor cells remains to be studied. Therefore, our current study aimed to briefly review the role of RhoA in GC, especially for its associated signaling pathways involved in the GC progression.

scholarly journals SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation

2020 ◽  
Author(s):  
Yoshimi Yasukawa ◽  
Naoko Hattori ◽  
Naoko Iida ◽  
Hideyuki Takeshima ◽  
Masahiro Maeda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Chromatin Immunoprecipitation ◽  
Therapeutic Target ◽  
Cancer Associated Fibroblasts ◽  
Promoting Effect ◽  
Gastric Cancer Cells ◽  
Potential Therapeutic Target ◽  
Active Enhancer ◽  
Serum Amyloid A1

Abstract Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs from gastric cancer and a mechanism for its dysregulation. Expression microarray using eight CAFs and seven non-CAFs (NCAFs) revealed that serum amyloid A1 (SAA1), which encodes an acute phase secreted protein, was second most upregulated in CAFs, following IGF2. Conditioned medium (CM) derived from SAA1-overexpressing NCAFs was shown to increase migration of gastric cancer cells compared to that from control NCAFs, and its tumor-promoting effect was comparable to that of CM from CAFs. In addition, increased migration of cancer cells by CM from CAFs was mostly canceled with CM from CAFs with SAA1 knockdown. Chromatin immunoprecipitation (ChIP)-quantitative PCR showed that CAFs had higher levels of H3K27ac, an active enhancer mark, in the promoter and the two far upstream regions of SAA1 than NCAFs. Also, BET bromodomain inhibitors, JQ1 and mivebresib, decreased SAA1 expression and tumor-promoting effects in CAFs, suggesting SAA1 upregulation by enhancer activation in CAFs. Our present data showed that SAA1 is a candidate therapeutic target from gastric CAFs and indicated that increased enhancer acetylation is important for its overexpression.

scholarly journals Intratumoral pseudoaneurysm within a liver metastasis of gastric cancer: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Hiroki Ohara ◽  
Yuji Ishibashi ◽  
Shuntaro Yoshimura ◽  
Ryoto Yamazaki ◽  
Fumihiko Hatao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Liver Metastasis

Recurrence of gastric cancer caused by implantation of tumor cells after curative endoscopic submucosal dissection

2021 ◽  
Author(s):  
Michiko Nakaoka ◽  
Tetsuo Nemoto ◽  
Hideyuki Chiba ◽  
Naoya Okada ◽  
Jun Tachikawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Tumor Cells ◽  
Submucosal Dissection
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