Safe and Efficient Peripheral Blood Stem Cell Collection in Patients with Sickle Cell Disease Using Plerixafor

2019 ◽  
Author(s):  
Naoya Uchida ◽  
Alexis Leonard ◽  
David Stroncek ◽  
Sandhya R. Panch ◽  
Kamille West ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
Cell Disease ◽  
Stem Cell Collection

scholarly journals Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor

Haematologica ◽  
2020 ◽  
Vol 105 (10) ◽  
pp. e497 ◽  
Author(s):  
Naoya Uchida ◽  
Alexis Leonard ◽  
David Stroncek ◽  
Sandhya R. Panch ◽  
Kamille West ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
Cell Disease ◽  
Stem Cell Collection

scholarly journals Peripheral blood stem cell transplant-relatedPlasmodium falciparuminfection in a patient with sickle cell disease

Transfusion ◽  
2012 ◽  
Vol 52 (12) ◽  
pp. 2677-2682 ◽  
Author(s):  
Rojelio Mejia ◽  
Garrett S. Booth ◽  
Daniel P. Fedorko ◽  
Matthew M. Hsieh ◽  
Hanh M. Khuu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Peripheral Blood ◽  
Stem Cell Transplant ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
Cell Transplant ◽  
Cell Disease

scholarly journals Infusion of hemolyzed red blood cells within peripheral blood stem cell grafts in patients with and without sickle cell disease

Blood ◽  
2012 ◽  
Vol 119 (24) ◽  
pp. 5671-5673 ◽  
Author(s):  
Courtney D. Fitzhugh ◽  
Hayato Unno ◽  
Vincent Hathaway ◽  
Wynona A. Coles ◽  
Mary E. Link ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Stem Cell ◽  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Stem Cell ◽  
Cell Disease ◽  
Free Hemoglobin

Abstract Peripheral blood stem cell (PBSC) infusions are associated with complications such as elevated blood pressure and decreased creatinine clearance. Patients with sickle cell disease experience similar manifestations, and some have postulated release of plasma-free hemoglobin with subsequent nitric oxide consumption as causative. We sought to evaluate whether the infusion of PBSC grafts containing lysed red blood cells (RBCs) leads to the toxicity observed in transplant subjects. We report a prospective cohort study of 60 subjects divided into 4 groups based on whether their infusions contained dimethyl sulfoxide (DMSO) and lysed RBCs, no DMSO and fresh RBCs, DMSO and no RBCs, or saline. Our primary end point, change in maximum blood pressure compared with baseline, was not significantly different among groups. Tricuspid regurgitant velocity and creatinine levels also did not differ significantly among groups. Our data do not support free hemoglobin as a significant contributor to toxicity associated with PBSC infusions. This study was registered at clinicaltrials.gov (NCT00631787).

Comparing peripheral blood stem cell collection using the COBE Spectra, Haemonetics MCS+, and Baxter Amicus

2012 ◽  
Vol 47 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Fei-yi Wu ◽  
Kee Khiang Heng ◽  
Rohani Binte Salleh ◽  
Teck Guan Soh ◽  
Jing Jing Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
Stem Cell Collection
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