Prognostic Value of Pre-Treatment Neutrophil-to-Lymphocyte Ratio and Platelet in Patients with Operable Head and Neck Squamous Cell Carcinoma

2019 ◽  
Author(s):  
Jing Ye ◽  
Bing Liao ◽  
Xiaohua Jiang ◽  
Zhihuai Dong ◽  
Sunhong Hu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Neck Squamous Cell Carcinoma ◽  
Lymphocyte Ratio ◽  
Pre Treatment

scholarly journals Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 7 (10) ◽  
pp. 294 ◽  
Author(s):  
Miao-Fen Chen ◽  
Ming-Shao Tsai ◽  
Wen-Cheng Chen ◽  
Ping-Tsung Chen
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Peripheral Circulation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Neck Squamous Cell Carcinoma ◽  
Clinicopathological Parameters ◽  
Lymphocyte Ratio

This study assessed the significance of the neutrophil-to-lymphocyte ratio (NLR) in head and neck squamous cell carcinoma (HNSCC), and the relationships of the NLR with the aldehyde dehydrogenase 1 (ALDH1) level in tumors and the proportion of myeloid-derived suppressor cells (MDSCs) in the peripheral circulation. In total, 227 HNSCC patients who had received curative treatment at our hospital were enrolled into the present study. The NLR of each HNSCC patient before treatment was calculated. The associations of NLR with various clinicopathological parameters and prognoses were then examined. In addition, correlations between the proportion of MDSCs and level of ALDH1 with the NLR were assessed. Our data revealed that an elevated NLR was significantly correlated with the risk of developing locoregional recurrence and with a reduced overall survival in HNSCC patients. Multivariate analyses revealed that the NLR pretreatment and surgical resection were significantly correlated with the rate of treatment failure and the overall survival rate in HNSCC patients. Furthermore, the levels of ALDH1 in tumors and MDSCs in the peripheral circulation were significantly correlated with the prognosis of HNSCC, and the NLR was positively correlated with MDSC levels in the circulation and ALDH1 staining intensity in tumor specimens. In conclusion, the NLR has power in predicting the expression of ALDH1 in tumors, the circulating level of MDSCs, and the prognosis in HNSCC. We suggest that the NLR is an important biomarker that can assist the clinician and patient in making informed decisions regarding treatment options for HNSCC patients.

scholarly journals Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E1068-E1074 ◽  
Author(s):  
Saleh Rachidi ◽  
Kristin Wallace ◽  
John M. Wrangle ◽  
Terry A. Day ◽  
Anthony J. Alberg ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neutrophil To Lymphocyte Ratio ◽  
Neck Squamous Cell Carcinoma ◽  
Lymphocyte Ratio
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