Oxidative and Advanced Glycation End-Products Biomarkers and Their Association with the Risk of Cardiovascular Disease Outcomes in Type 1 Diabetes in DCCT/EDIC

2019 ◽  
Author(s):  
Paul Beisswenger ◽  
Ionut Bebu ◽  
Scott Howell ◽  
John M. Lachin ◽  
DCCT/EDIC Research Group
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Disease Outcomes ◽  
Glycation End Products ◽  
End Products

scholarly journals Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Eva O. Melin ◽  
Jonatan Dereke ◽  
Magnus Hillman
Keyword(s):  
Type 1 Diabetes ◽  
Advanced Glycation End Products ◽  
Inflammatory Responses ◽  
Lipid Lowering ◽  
Advanced Glycation ◽  
Cross Sectional ◽  
Lipid Lowering Drugs ◽  
Glycation End Products ◽  
End Products

Abstract Background The receptors for advanced glycation end products (RAGE) are increased in atherosclerotic plaques. Soluble (s)RAGE decreases, whereas the extracellular newly identified receptor for advanced glycation end products (EN-RAGE) increases inflammatory responses mediated by RAGE. The aims were to explore whether sRAGE, EN-RAGE and the EN-RAGE/sRAGE ratio, were associated with the use of lipid-lowering drugs (LLD) and/or antihypertensive drugs (AHD) in patients with type 1 diabetes (T1D). Methods Cross-sectional design. T1D patients were consecutively recruited from one diabetes clinic. Blood samples were collected, supplemented with data from electronic health records. sRAGE and EN-RAGE were analysed by enzyme linked immunosorbent assays. An EN-RAGE/sRAGE ratio was calculated. Adjustments were performed with inflammatory and metabolic variables, s-creatinine, depression, smoking, physical inactivity, medication, and cardiovascular complications. Multiple regression analyses were performed. Results In this study 283 T1D patients (men 56%, 18–59 years) were included. One-hundred and thirty LLD users compared to 153 non-users had lower levels of the EN-RAGE/sRAGE ratio (P = 0.009), and 89 AHD users compared to 194 non-users had lower levels of sRAGE (P = 0.031). The use of LLD (inversely) (B coefficient − 0.158, P = 0.033) and the use of AHD (B coefficient 0.187, P = 0.023) were associated with the EN-RAGE/sRAGE ratio. sRAGE (Lg10) (per unit) (adjusted odds ratio (AOR) = 3.5, 95% CI = 1.4–9.1, P = 0.009), EN-RAGE (Lg10) (per unit) (inversely) (AOR 0.4, 95% CI = 0.2–1.0, P = 0.046), age (P <  0.001), and triglycerides (P <  0.029), were associated with LLD. sRAGE (Lg10) (per unit) (inversely) (AOR = 0.2, 95% CI = 0.1–0.5, P = 0.001), diabetes duration, triglycerides, s-creatinine, and systolic BP (all P values < 0.043), were associated with AHD. Conclusions Higher sRAGE levels and lower EN-RAGE levels were linked to the use of LLD, whereas lower sRAGE levels were linked to the use of AHD. No other variables but the use of LLD and the use of AHD were linked to the EN-RAGE/sRAGE ratio. This may be of major importance as sRAGE is an inhibitor and EN-RAGE is a stimulator of inflammatory processes mediated by RAGE.

scholarly journals Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes

2020 ◽  
Vol 40 (4) ◽  
pp. 1200-1219 ◽  
Author(s):  
Selena Le Bagge ◽  
Amelia K. Fotheringham ◽  
Sherman S. Leung ◽  
Josephine M. Forbes
Keyword(s):  
Type 1 Diabetes ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

The −429 T>C polymorphism of the receptor for advanced glycation end products (RAGE) is associated with type 1 diabetes in a Brazilian population

2007 ◽  
Vol 383 (1-2) ◽  
pp. 163-164 ◽  
Author(s):  
Geraldo Picheth ◽  
Márcia Heidemann ◽  
Fábio O. Pedrosa ◽  
Eleidi A. Chautard-Freire-Maia ◽  
Costantino O. Costantini ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Advanced Glycation End Products ◽  
Brazilian Population ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes

2020 ◽  
Vol 29 (10) ◽  
pp. 1193-1199
Author(s):  
Agnieszka Zawada ◽  
Dariusz Naskret ◽  
Paweł Niedźwiecki ◽  
Marian Grzymisławski ◽  
Dorota Zozulińska-Ziółkiewicz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Body Fat ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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